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Structure paper

TitleThe antibiotics linezolid and sutezolid are ligands for Mycobacterium tuberculosis EthR
Journal, issue, pagesTo Be Published
Publish dateMay 12, 2017 (structure data deposition date)
AuthorsNikiforov, P.O. / Blaszczyk, M. / Mendes, V. / Boshoff, H.I. / Barry, C.E. / Blundell, T.L. / Abell, C.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.825 - 2.33 Å
Structure data

PDB-5nz0:
Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with linezolid
Method: X-RAY DIFFRACTION / Resolution: 1.825 Å

PDB-5nz1:
Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with sutezolid
Method: X-RAY DIFFRACTION / Resolution: 2.33 Å

Chemicals

ChemComp-ZLD:
N-{[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide / antibiotic*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-9EN:
~{N}-[[(5~{S})-3-(3-fluoranyl-4-thiomorpholin-4-yl-phenyl)-2-oxidanylidene-1,3-oxazolidin-5-yl]methyl]ethanamide

Source
  • mycobacterium tuberculosis (bacteria)
KeywordsTRANSCRIPTION / EthR / represor / boosting effect

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