Entry | Database: PDB / ID: 5n49 |
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Title | BRPF2 in complex with Compound 7 |
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Components | Bromodomain-containing protein 1 |
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Keywords | TRANSCRIPTION / bromodomain / chemical probe |
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Function / homology | Function and homology information
histone H3-K14 acetyltransferase complex / regulation of developmental process / regulation of hemopoiesis / MOZ/MORF histone acetyltransferase complex / erythrocyte maturation / response to immobilization stress / response to electrical stimulus / Regulation of TP53 Activity through Acetylation / histone reader activity / positive regulation of erythrocyte differentiation ...histone H3-K14 acetyltransferase complex / regulation of developmental process / regulation of hemopoiesis / MOZ/MORF histone acetyltransferase complex / erythrocyte maturation / response to immobilization stress / response to electrical stimulus / Regulation of TP53 Activity through Acetylation / histone reader activity / positive regulation of erythrocyte differentiation / HATs acetylate histones / histone binding / perikaryon / nuclear speck / chromatin remodeling / dendrite / regulation of DNA-templated transcription / regulation of transcription by RNA polymerase II / nucleus / metal ion bindingSimilarity search - Function BRPF2, ePHD domain / BRPF2, PHD domain / Enhancer of polycomb-like, N-terminal / Enhancer of polycomb-like / PHD-finger / PHD-zinc-finger like domain / Extended PHD (ePHD) domain / Extended PHD (ePHD) domain profile. / domain with conserved PWWP motif / PWWP domain ...BRPF2, ePHD domain / BRPF2, PHD domain / Enhancer of polycomb-like, N-terminal / Enhancer of polycomb-like / PHD-finger / PHD-zinc-finger like domain / Extended PHD (ePHD) domain / Extended PHD (ePHD) domain profile. / domain with conserved PWWP motif / PWWP domain / PWWP domain profile. / PWWP domain / Zinc finger, PHD-type, conserved site / Zinc finger PHD-type signature. / Zinc finger PHD-type profile. / Zinc finger, PHD-finger / Zinc finger, PHD-type / PHD zinc finger / Bromodomain-like / Histone Acetyltransferase; Chain A / Zinc finger, FYVE/PHD-type / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Zinc finger, RING/FYVE/PHD-type / Up-down Bundle / Mainly AlphaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.94 Å |
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Authors | Bouche, L. / Christ, C.D. / Siegel, S. / Fernandez-Montalvan, A.E. / Holton, S.J. / Fedorov, O. / ter Laak, A. / Sugawara, T. / Stoeckigt, D. / Tallant, C. ...Bouche, L. / Christ, C.D. / Siegel, S. / Fernandez-Montalvan, A.E. / Holton, S.J. / Fedorov, O. / ter Laak, A. / Sugawara, T. / Stoeckigt, D. / Tallant, C. / Bennett, J. / Monteiro, O. / Saez, L.D. / Siejka, P. / Meier, J. / Puetter, V. / Weiske, J. / Mueller, S. / Huber, K.V.M. / Hartung, I.V. / Haendler, B. |
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Citation | Journal: J. Med. Chem. / Year: 2017 Title: Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains. Authors: Bouche, L. / Christ, C.D. / Siegel, S. / Fernandez-Montalvan, A.E. / Holton, S.J. / Fedorov, O. / Ter Laak, A. / Sugawara, T. / Stockigt, D. / Tallant, C. / Bennett, J. / Monteiro, O. / Diaz- ...Authors: Bouche, L. / Christ, C.D. / Siegel, S. / Fernandez-Montalvan, A.E. / Holton, S.J. / Fedorov, O. / Ter Laak, A. / Sugawara, T. / Stockigt, D. / Tallant, C. / Bennett, J. / Monteiro, O. / Diaz-Saez, L. / Siejka, P. / Meier, J. / Putter, V. / Weiske, J. / Muller, S. / Huber, K.V.M. / Hartung, I.V. / Haendler, B. |
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History | Deposition | Feb 10, 2017 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | May 3, 2017 | Provider: repository / Type: Initial release |
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Revision 1.1 | May 10, 2017 | Group: Database references |
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Revision 1.2 | May 24, 2017 | Group: Database references |
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Revision 1.3 | May 8, 2024 | Group: Data collection / Database references / Structure summary Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_contact_author Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_contact_author.email |
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