登録情報 | データベース: PDB / ID: 5mt0 |
---|
タイトル | COMPLEMENT FACTOR D IN COMPLEX WITH A REVERSIBLE INDOLE CARBOXYLIC ACID BASED INHIBITOR |
---|
要素 | Complement factor D |
---|
キーワード | HYDROLASE |
---|
機能・相同性 | 機能・相同性情報
complement factor D / Alternative complement activation / complement activation, alternative pathway / complement activation / serine-type peptidase activity / platelet alpha granule lumen / response to bacterium / Platelet degranulation / secretory granule lumen / ficolin-1-rich granule lumen ...complement factor D / Alternative complement activation / complement activation, alternative pathway / complement activation / serine-type peptidase activity / platelet alpha granule lumen / response to bacterium / Platelet degranulation / secretory granule lumen / ficolin-1-rich granule lumen / serine-type endopeptidase activity / Neutrophil degranulation / proteolysis / extracellular exosome / extracellular region類似検索 - 分子機能 Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, histidine active site. / Serine proteases, trypsin domain profile. / Serine proteases, trypsin family, serine active site. / Trypsin-like serine protease / Serine proteases, trypsin domain / Trypsin / Trypsin-like serine proteases ...Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, histidine active site. / Serine proteases, trypsin domain profile. / Serine proteases, trypsin family, serine active site. / Trypsin-like serine protease / Serine proteases, trypsin domain / Trypsin / Trypsin-like serine proteases / Thrombin, subunit H / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / Beta Barrel / Mainly Beta類似検索 - ドメイン・相同性 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.29 Å |
---|
データ登録者 | Mac Sweeney, A. / Ostermann, N. |
---|
引用 | ジャーナル: J. Med. Chem. / 年: 2017 タイトル: Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors. 著者: Vulpetti, A. / Randl, S. / Rudisser, S. / Ostermann, N. / Erbel, P. / Mac Sweeney, A. / Zoller, T. / Salem, B. / Gerhartz, B. / Cumin, F. / Hommel, U. / Dalvit, C. / Lorthiois, E. / Maibaum, J. |
---|
履歴 | 登録 | 2017年1月6日 | 登録サイト: PDBE / 処理サイト: PDBE |
---|
改定 1.0 | 2017年2月15日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2017年3月22日 | Group: Database references |
---|
改定 1.2 | 2019年2月20日 | Group: Advisory / Data collection / Derived calculations カテゴリ: pdbx_data_processing_status / pdbx_validate_symm_contact ...pdbx_data_processing_status / pdbx_validate_symm_contact / struct_conn / struct_conn_type |
---|
改定 1.3 | 2024年5月1日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
---|
|
---|