登録情報 | データベース: PDB / ID: 5mri |
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タイトル | Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with Triazolone 18 |
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要素 | Sortilin |
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キーワード | SIGNALING PROTEIN / Vps10p / Receptor / Sortilin |
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機能・相同性 | 機能・相同性情報
neurotensin receptor activity, non-G protein-coupled / Golgi to lysosome transport / plasma membrane to endosome transport / myotube differentiation / nerve growth factor receptor activity / maintenance of synapse structure / cerebellar climbing fiber to Purkinje cell synapse / Golgi to endosome transport / retromer complex binding / endosome transport via multivesicular body sorting pathway ...neurotensin receptor activity, non-G protein-coupled / Golgi to lysosome transport / plasma membrane to endosome transport / myotube differentiation / nerve growth factor receptor activity / maintenance of synapse structure / cerebellar climbing fiber to Purkinje cell synapse / Golgi to endosome transport / retromer complex binding / endosome transport via multivesicular body sorting pathway / nerve growth factor binding / vesicle organization / protein targeting to lysosome / trans-Golgi network transport vesicle / clathrin-coated vesicle / Golgi cisterna membrane / endosome to lysosome transport / Golgi Associated Vesicle Biogenesis / negative regulation of fat cell differentiation / neurotrophin TRK receptor signaling pathway / D-glucose import / extrinsic apoptotic signaling pathway via death domain receptors / neuropeptide signaling pathway / clathrin-coated pit / ossification / response to insulin / endocytosis / regulation of gene expression / cytoplasmic vesicle / nuclear membrane / early endosome / lysosome / endosome membrane / G protein-coupled receptor signaling pathway / lysosomal membrane / endoplasmic reticulum membrane / perinuclear region of cytoplasm / enzyme binding / cell surface / Golgi apparatus / membrane / plasma membrane / cytosol類似検索 - 分子機能 Sortilin Vps10-D, 10CC-a domain / Wheat Germ Agglutinin (Isolectin 2); domain 1 - #270 / VPS10 / Sortilin, C-terminal / Sortilin, N-terminal / : / Sortilin, neurotensin receptor 3, C-terminal / Sortilin, neurotensin receptor 3, / VPS10 / Complement Module; domain 1 ...Sortilin Vps10-D, 10CC-a domain / Wheat Germ Agglutinin (Isolectin 2); domain 1 - #270 / VPS10 / Sortilin, C-terminal / Sortilin, N-terminal / : / Sortilin, neurotensin receptor 3, C-terminal / Sortilin, neurotensin receptor 3, / VPS10 / Complement Module; domain 1 / Wheat Germ Agglutinin (Isolectin 2); domain 1 / Ribbon / WD40/YVTN repeat-like-containing domain superfamily / 2-Layer Sandwich / Mainly Beta / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2 Å |
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データ登録者 | Andersen, J.L. / Strandbygaard, D. / Thirup, S. |
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資金援助 | デンマーク, 2件 組織 | 認可番号 | 国 |
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DanScatt: the Danish Centre for the Use of Synchrotron X-ray and Neutron Facilities | | デンマーク | European Community Seventh Framework Programme under BioStruct-X | 283570 | デンマーク |
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引用 | ジャーナル: Bioorg. Med. Chem. Lett. / 年: 2017 タイトル: The identification of novel acid isostere based inhibitors of the VPS10P family sorting receptor Sortilin. 著者: Andersen, J.L. / Lindberg, S. / Langgard, M. / Maltas, P.J. / Ronn, L.C.B. / Bundgaard, C. / Strandbygaard, D. / Thirup, S. / Watson, S.P. |
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履歴 | 登録 | 2016年12月23日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2017年5月17日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年8月9日 | Group: Database references / カテゴリ: citation_author / Item: _citation_author.name |
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改定 2.0 | 2020年7月29日 | Group: Atomic model / Data collection ...Atomic model / Data collection / Derived calculations / Structure summary カテゴリ: atom_site / chem_comp ...atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_struct_special_symmetry / struct_asym / struct_conn / struct_site / struct_site_gen Item: _atom_site.auth_asym_id / _atom_site.auth_seq_id ..._atom_site.auth_asym_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_entity_id / _chem_comp.name / _chem_comp.type / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_struct_special_symmetry.label_asym_id / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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改定 2.1 | 2024年1月17日 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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改定 2.2 | 2024年11月20日 | Group: Structure summary カテゴリ: pdbx_entry_details / pdbx_modification_feature |
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