登録情報 | データベース: PDB / ID: 5mco |
---|
タイトル | CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH ACTIVE SITE INHIBITOR GRL-8234 AND EXOSITE PEPTIDE |
---|
要素 | - BACE-1 EXOSITE PEPTIDE
- Beta-secretase 1
|
---|
キーワード | HYDROLASE / PROTEASE INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR COMPLEX |
---|
機能・相同性 | 機能・相同性情報
memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition ...memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition / detection of mechanical stimulus involved in sensory perception of pain / protein serine/threonine kinase binding / cellular response to copper ion / presynaptic modulation of chemical synaptic transmission / multivesicular body / hippocampal mossy fiber to CA3 synapse / response to lead ion / trans-Golgi network / recycling endosome / protein processing / cellular response to amyloid-beta / positive regulation of neuron apoptotic process / late endosome / synaptic vesicle / peptidase activity / amyloid-beta binding / endopeptidase activity / amyloid fibril formation / aspartic-type endopeptidase activity / early endosome / lysosome / endosome membrane / endosome / membrane raft / Amyloid fiber formation / endoplasmic reticulum lumen / axon / neuronal cell body / dendrite / Golgi apparatus / enzyme binding / cell surface / proteolysis / membrane / plasma membrane類似検索 - 分子機能 Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ...Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta類似検索 - ドメイン・相同性 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.49 Å |
---|
データ登録者 | Kuglstatter, A. / Stihle, M. / Benz, J. |
---|
引用 | ジャーナル: EBioMedicine / 年: 2017 タイトル: Potent and Selective BACE-1 Peptide Inhibitors Lower Brain A beta Levels Mediated by Brain Shuttle Transport. 著者: Ruderisch, N. / Schlatter, D. / Kuglstatter, A. / Guba, W. / Huber, S. / Cusulin, C. / Benz, J. / Rufer, A.C. / Hoernschemeyer, J. / Schweitzer, C. / Bulau, T. / Gartner, A. / Hoffmann, E. / ...著者: Ruderisch, N. / Schlatter, D. / Kuglstatter, A. / Guba, W. / Huber, S. / Cusulin, C. / Benz, J. / Rufer, A.C. / Hoernschemeyer, J. / Schweitzer, C. / Bulau, T. / Gartner, A. / Hoffmann, E. / Niewoehner, J. / Patsch, C. / Baumann, K. / Loetscher, H. / Kitas, E. / Freskgard, P.O. |
---|
履歴 | 登録 | 2016年11月10日 | 登録サイト: PDBE / 処理サイト: PDBE |
---|
改定 1.0 | 2017年9月27日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2017年11月1日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
---|
改定 1.2 | 2024年5月1日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
---|
|
---|