Entry | Database: PDB / ID: 5mbw |
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Title | CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH Pep#3 |
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Components | - BACE1 INHIBITOR PEPTIDE Pep#3
- Beta-secretase 1
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Keywords | HYDROLASE / PROTEASE INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR COMPLEX |
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Function / homology | Function and homology information
memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition ...memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition / detection of mechanical stimulus involved in sensory perception of pain / protein serine/threonine kinase binding / cellular response to copper ion / presynaptic modulation of chemical synaptic transmission / hippocampal mossy fiber to CA3 synapse / multivesicular body / response to lead ion / trans-Golgi network / protein processing / recycling endosome / cellular response to amyloid-beta / positive regulation of neuron apoptotic process / synaptic vesicle / late endosome / peptidase activity / amyloid-beta binding / endopeptidase activity / amyloid fibril formation / aspartic-type endopeptidase activity / lysosome / early endosome / endosome membrane / endosome / membrane raft / Amyloid fiber formation / endoplasmic reticulum lumen / axon / neuronal cell body / dendrite / Golgi apparatus / enzyme binding / cell surface / proteolysis / membrane / plasma membraneSimilarity search - Function Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ...Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly BetaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.95 Å |
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Authors | Kuglstatter, A. / Stihle, M. / Benz, J. |
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Citation | Journal: EBioMedicine / Year: 2017 Title: Potent and Selective BACE-1 Peptide Inhibitors Lower Brain A beta Levels Mediated by Brain Shuttle Transport. Authors: Ruderisch, N. / Schlatter, D. / Kuglstatter, A. / Guba, W. / Huber, S. / Cusulin, C. / Benz, J. / Rufer, A.C. / Hoernschemeyer, J. / Schweitzer, C. / Bulau, T. / Gartner, A. / Hoffmann, E. / ...Authors: Ruderisch, N. / Schlatter, D. / Kuglstatter, A. / Guba, W. / Huber, S. / Cusulin, C. / Benz, J. / Rufer, A.C. / Hoernschemeyer, J. / Schweitzer, C. / Bulau, T. / Gartner, A. / Hoffmann, E. / Niewoehner, J. / Patsch, C. / Baumann, K. / Loetscher, H. / Kitas, E. / Freskgard, P.O. |
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History | Deposition | Nov 9, 2016 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Sep 27, 2017 | Provider: repository / Type: Initial release |
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Revision 1.1 | Nov 1, 2017 | Group: Database references / Category: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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