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- PDB-5m8t: Crystal structure of human tyrosinase related protein 1 (T391V-R3... -
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Basic information
Entry | Database: PDB / ID: 5m8t | |||||||||
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Title | Crystal structure of human tyrosinase related protein 1 (T391V-R374S-Y362F) in complex with tropolone | |||||||||
![]() | 5,6-dihydroxyindole-2-carboxylic acid oxidase | |||||||||
![]() | UNKNOWN FUNCTION / human tyrosinase related protein 1 / melanin biosynthesis / tyrosinase / oxidoreductase | |||||||||
Function / homology | ![]() Oxidoreductases; Acting on paired donors, with incorporation or reduction of molecular oxygen; With another compound as one donor, and incorporation of one atom of oxygen into the other donor / acetoacetic acid metabolic process / Melanin biosynthesis / positive regulation of melanin biosynthetic process / tyrosinase activity / melanocyte differentiation / melanin biosynthetic process / melanosome membrane / melanosome organization / intracellular vesicle ...Oxidoreductases; Acting on paired donors, with incorporation or reduction of molecular oxygen; With another compound as one donor, and incorporation of one atom of oxygen into the other donor / acetoacetic acid metabolic process / Melanin biosynthesis / positive regulation of melanin biosynthetic process / tyrosinase activity / melanocyte differentiation / melanin biosynthetic process / melanosome membrane / melanosome organization / intracellular vesicle / clathrin-coated endocytic vesicle membrane / melanosome / oxidoreductase activity / endosome membrane / protein homodimerization activity / metal ion binding / cytoplasm Similarity search - Function | |||||||||
Biological species | ![]() | |||||||||
Method | ![]() ![]() | |||||||||
![]() | Lai, X. / Soler-Lopez, M. / Wichers, H.J. / Dijkstra, B.W. | |||||||||
![]() | ![]() Title: Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis. Authors: Lai, X. / Wichers, H.J. / Soler-Lopez, M. / Dijkstra, B.W. | |||||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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PDBx/mmCIF format | ![]() | 382.9 KB | Display | ![]() |
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PDB format | ![]() | 320 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Summary document | ![]() | 6.1 MB | Display | ![]() |
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Full document | ![]() | 6.2 MB | Display | |
Data in XML | ![]() | 72.5 KB | Display | |
Data in CIF | ![]() | 101.2 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 5m8lC ![]() 5m8mC ![]() 5m8nC ![]() 5m8oC ![]() 5m8pC ![]() 5m8qC ![]() 5m8rC C: citing same article ( |
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Similar structure data |
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Assembly
Deposited unit | ![]()
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Noncrystallographic symmetry (NCS) | NCS domain:
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