Entry Database : PDB / ID : 5lrn Structure visualization Downloads & linksTitle Structure of mono-zinc MCR-1 in P21 space group ComponentsPhosphatidylethanolamine transferase Mcr-1 Details Keywords TRANSFERASE / phosphotehanolamine / metalloenzyme / colistin / antibiotic resistanceFunction / homology Function and homology informationFunction Domain/homology Component
phosphotransferase activity, phosphate group as acceptor / Transferases; Transferring phosphorus-containing groups / lipopolysaccharide core region biosynthetic process / response to antibiotic / plasma membrane Similarity search - Function Phosphoethanolamine transferase, N-terminal / Phosphoethanolamine transferase EptA/EptB / Phosphoethanolamine transferase / Sulfatase, N-terminal / Sulfatase / Alkaline Phosphatase, subunit A / Alkaline Phosphatase, subunit A / Alkaline-phosphatase-like, core domain superfamily / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Escherichia coli (E. coli)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.55 Å DetailsAuthors Hinchliffe, P. / Paterson, N.G. / Spencer, J. Funding support United Kingdom, China, 4items Details Hide detailsOrganization Grant number Country Medical Research Council (United Kingdom) MR/P007295/1 United Kingdom National Natural Science Foundation of China 31530076 China National Natural Science Foundation of China 8161101130 China National Natural Science Foundation of China 31422055 China
CitationJournal : Sci Rep / Year : 2017Title : Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1.Authors: Hinchliffe, P. / Yang, Q.E. / Portal, E. / Young, T. / Li, H. / Tooke, C.L. / Carvalho, M.J. / Paterson, N.G. / Brem, J. / Niumsup, P.R. / Tansawai, U. / Lei, L. / Li, M. / Shen, Z. / Wang, ... Authors : Hinchliffe, P. / Yang, Q.E. / Portal, E. / Young, T. / Li, H. / Tooke, C.L. / Carvalho, M.J. / Paterson, N.G. / Brem, J. / Niumsup, P.R. / Tansawai, U. / Lei, L. / Li, M. / Shen, Z. / Wang, Y. / Schofield, C.J. / Mulholland, A.J. / Shen, J. / Fey, N. / Walsh, T.R. / Spencer, J. History Deposition Aug 19, 2016 Deposition site : PDBE / Processing site : PDBERevision 1.0 Dec 7, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Jan 18, 2017 Group : Database referencesRevision 1.2 Sep 13, 2017 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.3 Jan 24, 2018 Group : Source and taxonomy / Category : entity_src_genItem : _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id / _entity_src_gen.pdbx_host_org_scientific_name ... _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id / _entity_src_gen.pdbx_host_org_scientific_name / _entity_src_gen.pdbx_host_org_strain / _entity_src_gen.pdbx_host_org_variant Revision 1.4 Jan 17, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_conn_type Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn_type.id
Show all Show less