登録情報 | データベース: PDB / ID: 5lhn |
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タイトル | The catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7 |
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要素 | - Camelid-Derived Antibody Fragment Nb7
- Urokinase-type plasminogen activator
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キーワード | Hydrolase/Antibody / Trypsin-like serine proteases / Nanobody / Inhibitor / Hydrolase-Antibody complex |
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機能・相同性 | 機能・相同性情報
Dissolution of Fibrin Clot / regulation of hepatocyte proliferation / skeletal muscle tissue regeneration / u-plasminogen activator / regulation of smooth muscle cell-matrix adhesion / urokinase plasminogen activator signaling pathway / regulation of plasminogen activation / regulation of fibrinolysis / protein complex involved in cell-matrix adhesion / negative regulation of plasminogen activation ...Dissolution of Fibrin Clot / regulation of hepatocyte proliferation / skeletal muscle tissue regeneration / u-plasminogen activator / regulation of smooth muscle cell-matrix adhesion / urokinase plasminogen activator signaling pathway / regulation of plasminogen activation / regulation of fibrinolysis / protein complex involved in cell-matrix adhesion / negative regulation of plasminogen activation / serine-type endopeptidase complex / smooth muscle cell migration / plasminogen activation / positive regulation of smooth muscle cell migration / regulation of cell adhesion mediated by integrin / negative regulation of fibrinolysis / regulation of cell adhesion / serine protease inhibitor complex / fibrinolysis / Neutrophil degranulation / positive regulation of reactive oxygen species metabolic process / peptidase activity / regulation of cell population proliferation / angiogenesis / response to hypoxia / positive regulation of cell migration / external side of plasma membrane / serine-type endopeptidase activity / positive regulation of cell population proliferation / extracellular space類似検索 - 分子機能 Kringle domain / Kringle / Kringle, conserved site / Kringle superfamily / Kringle domain signature. / Kringle domain profile. / Kringle domain / Kringle-like fold / EGF-like domain profile. / EGF-like domain signature 1. ...Kringle domain / Kringle / Kringle, conserved site / Kringle superfamily / Kringle domain signature. / Kringle domain profile. / Kringle domain / Kringle-like fold / EGF-like domain profile. / EGF-like domain signature 1. / EGF-like domain / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin domain profile. / Serine proteases, trypsin family, serine active site. / Trypsin-like serine protease / Serine proteases, trypsin domain / Trypsin / Trypsin-like serine proteases / Thrombin, subunit H / Immunoglobulins / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / Immunoglobulin-like / Beta Barrel / Sandwich / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Mus musculus (ハツカネズミ) Vicugna pacos (アルパカ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.55 Å |
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データ登録者 | Kromann-Hansen, T. / Lange, E.L. / Sorensen, H.P. / Ghassabeh, G.H. / Huang, M. / Jensen, J.K. / Muyldermans, S. / Declerck, P. / Andreasen, P.A. |
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資金援助 | デンマーク, 中国, 4件 組織 | 認可番号 | 国 |
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Danish National Research Foundation | 26-331-6 | デンマーク | Natrual Science Foundation of China | 31161130356, 31170707, 31370737 | 中国 | Lundbeck Foundation | R83-A7826 | デンマーク | Carlsberg Foundation | CF15-0814 | デンマーク |
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引用 | ジャーナル: Sci Rep / 年: 2017 タイトル: Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator. 著者: Kromann-Hansen, T. / Louise Lange, E. / Peter Srensen, H. / Hassanzadeh-Ghassabeh, G. / Huang, M. / Jensen, J.K. / Muyldermans, S. / Declerck, P.J. / Komives, E.A. / Andreasen, P.A. |
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履歴 | 登録 | 2016年7月12日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2017年6月28日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年1月10日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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