Entry | Database: PDB / ID: 5lak |
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Title | Ligand-bound structure of Cavally Virus 3CL Protease |
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Components | - 3Cl Protease
- BEZ-TYR-TYR-ASN-ECC Peptide inhibitor
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Keywords | HYDROLASE / Protease / Mesonivirus / 3CL / peptide-bound |
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Function / homology | Function and homology information
3'-5'-RNA exonuclease activity / mRNA (nucleoside-2'-O-)-methyltransferase activity / cysteine-type endopeptidase activity / RNA-dependent RNA polymerase activity / zinc ion binding / membraneSimilarity search - Function Viral cysteine endopeptidase C107 / Viral cysteine endopeptidase C107 / LAP1C-like, C-terminal domain superfamily / : / DNA2/NAM7-like helicase / AAA domain / Nidovirus 2-O-methyltransferase / Nidovirus 3'-5' exoribonuclease domain / Nidovirus 2'-O-methyltransferase (2'-O-MTase) domain profile. / Nidovirus 3'-5' exoribonuclease (ExoN) domain profile. ...Viral cysteine endopeptidase C107 / Viral cysteine endopeptidase C107 / LAP1C-like, C-terminal domain superfamily / : / DNA2/NAM7-like helicase / AAA domain / Nidovirus 2-O-methyltransferase / Nidovirus 3'-5' exoribonuclease domain / Nidovirus 2'-O-methyltransferase (2'-O-MTase) domain profile. / Nidovirus 3'-5' exoribonuclease (ExoN) domain profile. / Nonstructural protein 13, zinc-binding domain, coronavirus-like / Coronaviridae zinc-binding (CV ZBD) domain profile. / DNA2/NAM7 helicase-like, C-terminal / AAA domain / DNA/RNA polymerase superfamily / P-loop containing nucleoside triphosphate hydrolaseSimilarity search - Domain/homology |
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Biological species | Cavally virus synthetic construct (others) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.299 Å |
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Authors | Kanitz, M. / Heine, A. / Diederich, W.E. |
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Citation | Journal: Virology / Year: 2019 Title: Structural basis for catalysis and substrate specificity of a 3C-like cysteine protease from a mosquito mesonivirus. Authors: Kanitz, M. / Blanck, S. / Heine, A. / Gulyaeva, A.A. / Gorbalenya, A.E. / Ziebuhr, J. / Diederich, W.E. |
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History | Deposition | Jun 14, 2016 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Jul 12, 2017 | Provider: repository / Type: Initial release |
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Revision 1.1 | May 22, 2019 | Group: Data collection / Database references / Category: citation / citation_author / pdbx_database_proc Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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Revision 1.2 | Dec 25, 2019 | Group: Derived calculations Category: pdbx_struct_assembly_gen / pdbx_struct_assembly_prop Item: _pdbx_struct_assembly_gen.asym_id_list / _pdbx_struct_assembly_prop.value |
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Revision 1.3 | Jan 10, 2024 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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