Entry Database : PDB / ID : 5l6w Structure visualization Downloads & linksTitle Structure Of the LIMK1-ATPgammaS-CFL1 Complex ComponentsCofilin-1 LIM domain kinase 1 DetailsKeywords TRANSFERASE / kinase complexFunction / homology Function and homology informationFunction Domain/homology Component
actin filament fragmentation / positive regulation of embryonic development / establishment of spindle localization / positive regulation of actin filament bundle assembly / negative regulation of ubiquitin-protein transferase activity / actin filament severing / regulation of dendritic spine morphogenesis / positive regulation by host of viral process / actin filament depolymerization / RHO GTPases Activate ROCKs ... actin filament fragmentation / positive regulation of embryonic development / establishment of spindle localization / positive regulation of actin filament bundle assembly / negative regulation of ubiquitin-protein transferase activity / actin filament severing / regulation of dendritic spine morphogenesis / positive regulation by host of viral process / actin filament depolymerization / RHO GTPases Activate ROCKs / axon extension / regulation of cell morphogenesis / Sema4D induced cell migration and growth-cone collapse / Fc-gamma receptor signaling pathway involved in phagocytosis / stress fiber assembly / RHO GTPases activate PAKs / lamellipodium membrane / Rho protein signal transduction / Sema3A PAK dependent Axon repulsion / mitotic cytokinesis / positive regulation of axon extension / positive regulation of stress fiber assembly / cytoskeleton organization / heat shock protein binding / EPHB-mediated forward signaling / Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation / male germ cell nucleus / response to virus / Regulation of actin dynamics for phagocytic cup formation / ruffle membrane / nuclear matrix / actin filament binding / actin cytoskeleton / Platelet degranulation / lamellipodium / nervous system development / growth cone / actin cytoskeleton organization / vesicle / postsynapse / cytoskeleton / non-specific serine/threonine protein kinase / protein kinase activity / nuclear speck / neuron projection / protein phosphorylation / protein serine kinase activity / focal adhesion / protein serine/threonine kinase activity / glutamatergic synapse / negative regulation of apoptotic process / signal transduction / extracellular space / extracellular exosome / ATP binding / membrane / nucleus / metal ion binding / cytosol / cytoplasm Similarity search - Function : / ADF/Cofilin / Actin-depolymerising factor homology domain / Cofilin/tropomyosin-type actin-binding protein / ADF-H domain profile. / Actin depolymerisation factor/cofilin -like domains / Severin / Severin / LIM zinc-binding domain signature. / LIM domain ... : / ADF/Cofilin / Actin-depolymerising factor homology domain / Cofilin/tropomyosin-type actin-binding protein / ADF-H domain profile. / Actin depolymerisation factor/cofilin -like domains / Severin / Severin / LIM zinc-binding domain signature. / LIM domain / Zinc-binding domain present in Lin-11, Isl-1, Mec-3. / Zinc finger, LIM-type / LIM domain profile. / ADF-H/Gelsolin-like domain superfamily / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.53 Å DetailsAuthors Salah, E. / Mathea, S. / Oerum, S. / Newman, J.A. / Tallant, C. / Adamson, R. / Canning, P. / Beltrami, A. / von Delft, F. / Arrowsmith, C.H. ...Salah, E. / Mathea, S. / Oerum, S. / Newman, J.A. / Tallant, C. / Adamson, R. / Canning, P. / Beltrami, A. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Knapp, S. / Bullock, A.N. CitationJournal : To Be Published Title : Structure Of the LIMK1-ATPgammaS-CFL1 ComplexAuthors : Salah, E. / Bullock, A.N. History Deposition May 31, 2016 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jun 8, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Oct 16, 2019 Group : Data collection / Category : reflns_shellRevision 1.2 Jan 10, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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