登録情報 | データベース: PDB / ID: 5l4h |
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タイトル | X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with 5-(2-BROMO-ETHYL)-5-ETHYL-PYRIMIDINE-2,4,6-TRIONE (brominated barbiturate) |
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要素 | Proton-gated ion channel |
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キーワード | MEMBRANE PROTEIN / TRANSPORT PROTEIN |
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機能・相同性 | 機能・相同性情報
sodium channel activity / extracellular ligand-gated monoatomic ion channel activity / potassium channel activity / transmembrane transporter complex / regulation of membrane potential / transmembrane signaling receptor activity / neuron projection / signal transduction / identical protein binding / plasma membrane類似検索 - 分子機能 Neurotransmitter-gated ion-channel transmembrane domain / Acetylcholine Binding Protein; Chain: A, / Neurotransmitter-gated ion-channel ligand-binding domain / Gamma-aminobutyric acid A receptor/Glycine receptor alpha / Neurotransmitter-gated ion-channel transmembrane domain superfamily / Neuronal acetylcholine receptor / Neurotransmitter-gated ion-channel / Neurotransmitter-gated ion-channel ligand-binding domain / Neurotransmitter-gated ion-channel ligand-binding domain superfamily / Neurotransmitter-gated ion-channel ligand binding domain ...Neurotransmitter-gated ion-channel transmembrane domain / Acetylcholine Binding Protein; Chain: A, / Neurotransmitter-gated ion-channel ligand-binding domain / Gamma-aminobutyric acid A receptor/Glycine receptor alpha / Neurotransmitter-gated ion-channel transmembrane domain superfamily / Neuronal acetylcholine receptor / Neurotransmitter-gated ion-channel / Neurotransmitter-gated ion-channel ligand-binding domain / Neurotransmitter-gated ion-channel ligand-binding domain superfamily / Neurotransmitter-gated ion-channel ligand binding domain / Methane Monooxygenase Hydroxylase; Chain G, domain 1 / Distorted Sandwich / Up-down Bundle / Mainly Beta / Mainly Alpha類似検索 - ドメイン・相同性 |
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生物種 | Gloeobacter violaceus (バクテリア) |
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手法 | X線回折 / シンクロトロン / 解像度: 3.3 Å |
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データ登録者 | Fourati, Z. / Ruza, R.R. / Delarue, M. |
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引用 | ジャーナル: J. Biol. Chem. / 年: 2017 タイトル: Barbiturates Bind in the GLIC Ion Channel Pore and Cause Inhibition by Stabilizing a Closed State. 著者: Fourati, Z. / Ruza, R.R. / Laverty, D. / Drege, E. / Delarue-Cochin, S. / Joseph, D. / Koehl, P. / Smart, T. / Delarue, M. |
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履歴 | 登録 | 2016年5月25日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2016年12月21日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2016年12月28日 | Group: Database references |
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改定 1.2 | 2017年2月15日 | Group: Database references |
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