登録情報 データベース : PDB / ID : 5l2s 構造の表示 ダウンロードとリンクタイトル The X-ray co-crystal structure of human CDK6 and Abemaciclib. 要素Cyclin-dependent kinase 6 詳細 キーワード Transferase/Transferase Inhibitor / cyclin-dependent kinase / kinase inhibitor / kinase selectivity / Transferase-Transferase Inhibitor complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
cyclin D2-CDK6 complex / cyclin D3-CDK6 complex / cyclin D1-CDK6 complex / cell dedifferentiation / Drug-mediated inhibition of CDK4/CDK6 activity / Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 / Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 / FBXO family protein binding / lateral ventricle development / negative regulation of myeloid cell differentiation ... cyclin D2-CDK6 complex / cyclin D3-CDK6 complex / cyclin D1-CDK6 complex / cell dedifferentiation / Drug-mediated inhibition of CDK4/CDK6 activity / Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 / Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 / FBXO family protein binding / lateral ventricle development / negative regulation of myeloid cell differentiation / Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) / type B pancreatic cell development / negative regulation of monocyte differentiation / astrocyte development / dentate gyrus development / gliogenesis / regulation of cell motility / cyclin-dependent kinase / Regulation of RUNX1 Expression and Activity / cyclin-dependent protein serine/threonine kinase activity / regulation of hematopoietic stem cell differentiation / positive regulation of cell-matrix adhesion / negative regulation of osteoblast differentiation / generation of neurons / cyclin-dependent protein kinase holoenzyme complex / regulation of G2/M transition of mitotic cell cycle / negative regulation of cellular senescence / : / negative regulation of cell differentiation / negative regulation of cell cycle / cyclin binding / hematopoietic stem cell differentiation / Notch signaling pathway / ruffle / response to virus / regulation of erythrocyte differentiation / Cyclin D associated events in G1 / Oncogene Induced Senescence / G1/S transition of mitotic cell cycle / positive regulation of fibroblast proliferation / negative regulation of epithelial cell proliferation / Senescence-Associated Secretory Phenotype (SASP) / regulation of gene expression / T cell differentiation in thymus / Oxidative Stress Induced Senescence / regulation of cell cycle / protein phosphorylation / cell division / negative regulation of cell population proliferation / protein serine kinase activity / centrosome / positive regulation of gene expression / negative regulation of transcription by RNA polymerase II / signal transduction / nucleoplasm / ATP binding / nucleus / cytoplasm / cytosol 類似検索 - 分子機能 Cyclin-dependent kinase 6 / : / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain ... Cyclin-dependent kinase 6 / : / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 解像度 : 2.27 Å 詳細データ登録者 Chen, P. / Ferre, R.A. / Deihl, W. / Yu, X. / He, Y.-A. 引用ジャーナル : Mol.Cancer Ther. / 年 : 2016タイトル : Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance.著者 : Chen, P. / Lee, N.V. / Hu, W. / Xu, M. / Ferre, R.A. / Lam, H. / Bergqvist, S. / Solowiej, J. / Diehl, W. / He, Y.A. / Yu, X. / Nagata, A. / VanArsdale, T. / Murray, B.W. 履歴 登録 2016年8月2日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2016年8月24日 Provider : repository / タイプ : Initial release改定 1.1 2016年10月19日 Group : Database references改定 1.2 2024年3月6日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Structure summary カテゴリ : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / entity / pdbx_entity_nonpoly / pdbx_struct_oper_list Item : _chem_comp.name / _database_2.pdbx_DOI ... _chem_comp.name / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _pdbx_struct_oper_list.symmetry_operation
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