Entry | Database: PDB / ID: 5kwy |
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Title | Structure of human NPC1 middle lumenal domain bound to NPC2 |
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Components | - Epididymal secretory protein E1
- Niemann-Pick C1 protein
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Keywords | TRANSPORT PROTEIN / human protein complex / NPC1 / NPC2 |
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Function / homology | Function and homology information
regulation of isoprenoid metabolic process / glycolipid transport / intracellular sterol transport / cyclodextrin metabolic process / cholesterol storage / membrane raft organization / intracellular cholesterol transport / intracellular lipid transport / intestinal cholesterol absorption / LDL clearance ...regulation of isoprenoid metabolic process / glycolipid transport / intracellular sterol transport / cyclodextrin metabolic process / cholesterol storage / membrane raft organization / intracellular cholesterol transport / intracellular lipid transport / intestinal cholesterol absorption / LDL clearance / lipid transporter activity / negative regulation of epithelial cell apoptotic process / phospholipid transport / cholesterol transfer activity / bile acid metabolic process / cholesterol transport / programmed cell death / establishment of protein localization to membrane / adult walking behavior / lysosomal transport / cholesterol efflux / cellular response to steroid hormone stimulus / negative regulation of macroautophagy / cholesterol binding / protein glycosylation / cellular response to low-density lipoprotein particle stimulus / response to cadmium ion / negative regulation of TORC1 signaling / cholesterol metabolic process / lysosomal lumen / neurogenesis / liver development / cholesterol homeostasis / macroautophagy / response to virus / autophagy / endocytosis / transmembrane signaling receptor activity / azurophil granule lumen / late endosome membrane / nuclear envelope / virus receptor activity / signaling receptor activity / gene expression / lysosome / response to xenobiotic stimulus / symbiont entry into host cell / membrane raft / lysosomal membrane / Neutrophil degranulation / perinuclear region of cytoplasm / Golgi apparatus / enzyme binding / endoplasmic reticulum / extracellular space / extracellular exosome / extracellular region / membrane / plasma membraneSimilarity search - Function Npc2 like, ML domain / Sterol transport protein NPC2-like / Immunoglobulin-like - #770 / NPC1-like / ML domain / MD-2-related lipid-recognition domain / Domain involved in innate immunity and lipid metabolism. / Niemann-Pick C1, N-terminal / Niemann-Pick C1 N terminus / Sterol-sensing domain of SREBP cleavage-activation ...Npc2 like, ML domain / Sterol transport protein NPC2-like / Immunoglobulin-like - #770 / NPC1-like / ML domain / MD-2-related lipid-recognition domain / Domain involved in innate immunity and lipid metabolism. / Niemann-Pick C1, N-terminal / Niemann-Pick C1 N terminus / Sterol-sensing domain of SREBP cleavage-activation / Protein patched/dispatched / Patched family / Sterol-sensing domain (SSD) profile. / Sterol-sensing domain / Immunoglobulin E-set / Immunoglobulin-like / Sandwich / Mainly BetaSimilarity search - Domain/homology CHOLEST-5-EN-3-YL HYDROGEN SULFATE / NPC intracellular cholesterol transporter 1 / NPC intracellular cholesterol transporter 2Similarity search - Component |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.405 Å |
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Authors | Li, X. |
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Citation | Journal: Proc.Natl.Acad.Sci.USA / Year: 2016 Title: Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2. Authors: Li, X. / Saha, P. / Li, J. / Blobel, G. / Pfeffer, S.R. |
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History | Deposition | Jul 19, 2016 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Aug 24, 2016 | Provider: repository / Type: Initial release |
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Revision 1.1 | Sep 7, 2016 | Group: Database references |
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Revision 1.2 | Sep 14, 2016 | Group: Database references |
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Revision 1.3 | Jul 29, 2020 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Structure summary Category: chem_comp / citation ...chem_comp / citation / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / pdbx_struct_oper_list / struct_conn / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _citation.journal_id_CSD / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _pdbx_struct_oper_list.symmetry_operation / _struct_conn.pdbx_role Description: Carbohydrate remediation / Provider: repository / Type: Remediation |
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Revision 1.4 | Oct 4, 2023 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary Category: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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