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TitleClues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 113, Page 10079-10084, Year 2016
Publish dateJul 19, 2016 (structure data deposition date)
AuthorsLi, X. / Saha, P. / Li, J. / Blobel, G. / Pfeffer, S.R.
External linksProc. Natl. Acad. Sci. USA / PubMed:27551080
MethodsX-ray diffraction
Resolution2.405 Å
Structure data

PDB-5kwy:
Structure of human NPC1 middle lumenal domain bound to NPC2
Method: X-RAY DIFFRACTION / Resolution: 2.405 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-C3S:
CHOLEST-5-EN-3-YL HYDROGEN SULFATE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / human protein complex / NPC1 / NPC2

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