登録情報 | データベース: PDB / ID: 5jsb |
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タイトル | Crystal structure of Mcl1-inhibitor complex |
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要素 | - Induced myeloid leukemia cell differentiation protein Mcl-1
- Mcl-1 inhibitor
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キーワード | Viral Protein/Inhibitor / McL-1 / antiMcl1 / complex / Viral Protein-Inhibitor complex |
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機能・相同性 | 機能・相同性情報
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / cell fate determination / cellular homeostasis / channel activity / mitochondrial fusion / Bcl-2 family protein complex / BH domain binding / BH3 domain binding / negative regulation of anoikis / protein transmembrane transporter activity ...positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / cell fate determination / cellular homeostasis / channel activity / mitochondrial fusion / Bcl-2 family protein complex / BH domain binding / BH3 domain binding / negative regulation of anoikis / protein transmembrane transporter activity / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / extrinsic apoptotic signaling pathway in absence of ligand / negative regulation of autophagy / release of cytochrome c from mitochondria / response to cytokine / intrinsic apoptotic signaling pathway in response to DNA damage / Signaling by ALK fusions and activated point mutants / Interleukin-4 and Interleukin-13 signaling / regulation of apoptotic process / mitochondrial outer membrane / positive regulation of apoptotic process / protein heterodimerization activity / DNA damage response / negative regulation of apoptotic process / mitochondrion / nucleoplasm / membrane / nucleus / cytosol / cytoplasm類似検索 - 分子機能 Ribosome-recycling factor / Apoptosis regulator, Mcl-1 / Topoisomerase I; Chain A, domain 4 / Blc2-like / Apoptosis Regulator Bcl-x / Apoptosis regulator, Bcl-2, BH3 motif, conserved site / Apoptosis regulator, Bcl-2 family BH3 motif signature. / Apoptosis regulator, Bcl-2, BH1 motif, conserved site / Apoptosis regulator, Bcl-2 family BH1 motif signature. / Apoptosis regulator, Bcl-2, BH2 motif, conserved site ...Ribosome-recycling factor / Apoptosis regulator, Mcl-1 / Topoisomerase I; Chain A, domain 4 / Blc2-like / Apoptosis Regulator Bcl-x / Apoptosis regulator, Bcl-2, BH3 motif, conserved site / Apoptosis regulator, Bcl-2 family BH3 motif signature. / Apoptosis regulator, Bcl-2, BH1 motif, conserved site / Apoptosis regulator, Bcl-2 family BH1 motif signature. / Apoptosis regulator, Bcl-2, BH2 motif, conserved site / Apoptosis regulator, Bcl-2 family BH2 motif signature. / BCL (B-Cell lymphoma); contains BH1, BH2 regions / Bcl-2 family / Bcl-2, Bcl-2 homology region 1-3 / Bcl2-like / Apoptosis regulator proteins, Bcl-2 family / BCL2-like apoptosis inhibitors family profile. / Bcl-2-like superfamily / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Induced myeloid leukemia cell differentiation protein Mcl-1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) synthetic construct (人工物) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.74 Å |
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データ登録者 | Shen, B.W. / Stoddard, B.L. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | NIH R01 GM115545 | 米国 |
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引用 | ジャーナル: Elife / 年: 2016 タイトル: Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer. 著者: Berger, S. / Procko, E. / Margineantu, D. / Lee, E.F. / Shen, B.W. / Zelter, A. / Silva, D.A. / Chawla, K. / Herold, M.J. / Garnier, J.M. / Johnson, R. / MacCoss, M.J. / Lessene, G. / Davis, ...著者: Berger, S. / Procko, E. / Margineantu, D. / Lee, E.F. / Shen, B.W. / Zelter, A. / Silva, D.A. / Chawla, K. / Herold, M.J. / Garnier, J.M. / Johnson, R. / MacCoss, M.J. / Lessene, G. / Davis, T.N. / Stayton, P.S. / Stoddard, B.L. / Fairlie, W.D. / Hockenbery, D.M. / Baker, D. |
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履歴 | 登録 | 2016年5月7日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2016年11月16日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2016年12月7日 | Group: Other |
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改定 1.2 | 2017年9月20日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.3 | 2019年12月25日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.4 | 2024年3月6日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_ncs_dom_lim Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id |
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改定 1.5 | 2024年4月3日 | Group: Refinement description / カテゴリ: pdbx_initial_refinement_model |
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