+Open data
-Basic information
Entry | Database: PDB / ID: 5jg8 | |||||||||
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Title | Crystal structure of human acid sphingomyelinase | |||||||||
Components | Sphingomyelin phosphodiesterase | |||||||||
Keywords | HYDROLASE / Lysosomal hydrolase / Neimann-Pick disease / Sphingolipid / Saposin | |||||||||
Function / homology | Function and homology information acid sphingomyelin phosphodiesterase activity / sphingomyelin catabolic process / sphingomyelin metabolic process / sphingomyelin phosphodiesterase / sphingomyelin phosphodiesterase activity / lamellar body / phospholipase C / phosphatidylcholine phospholipase C activity / endolysosome / termination of signal transduction ...acid sphingomyelin phosphodiesterase activity / sphingomyelin catabolic process / sphingomyelin metabolic process / sphingomyelin phosphodiesterase / sphingomyelin phosphodiesterase activity / lamellar body / phospholipase C / phosphatidylcholine phospholipase C activity / endolysosome / termination of signal transduction / glycosphingolipid catabolic process / ceramide biosynthetic process / plasma membrane repair / Glycosphingolipid catabolism / response to type I interferon / hydrolase activity, acting on glycosyl bonds / response to ionizing radiation / positive regulation of endocytosis / response to tumor necrosis factor / : / negative regulation of MAP kinase activity / cellular response to calcium ion / response to interleukin-1 / cholesterol metabolic process / lysosomal lumen / lipid droplet / response to cocaine / wound healing / response to virus / cellular response to UV / nervous system development / endosome / positive regulation of viral entry into host cell / lysosome / response to xenobiotic stimulus / symbiont entry into host cell / positive regulation of apoptotic process / signal transduction / extracellular space / zinc ion binding / extracellular exosome / plasma membrane Similarity search - Function | |||||||||
Biological species | Homo sapiens (human) | |||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.8 Å | |||||||||
Authors | Xiong, Z.J. / Prive, G.G. | |||||||||
Citation | Journal: J.Mol.Biol. / Year: 2016 Title: Structure of Human Acid Sphingomyelinase Reveals the Role of the Saposin Domain in Activating Substrate Hydrolysis. Authors: Xiong, Z.J. / Huang, J. / Poda, G. / Pomes, R. / Prive, G.G. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 5jg8.cif.gz | 230.5 KB | Display | PDBx/mmCIF format |
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PDB format | pdb5jg8.ent.gz | 183.4 KB | Display | PDB format |
PDBx/mmJSON format | 5jg8.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 5jg8_validation.pdf.gz | 2.4 MB | Display | wwPDB validaton report |
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Full document | 5jg8_full_validation.pdf.gz | 2.4 MB | Display | |
Data in XML | 5jg8_validation.xml.gz | 43.6 KB | Display | |
Data in CIF | 5jg8_validation.cif.gz | 58 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/jg/5jg8 ftp://data.pdbj.org/pub/pdb/validation_reports/jg/5jg8 | HTTPS FTP |
-Related structure data
Related structure data | 5ebeS S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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