Entry Database : PDB / ID : 5jcx Structure visualization Downloads & linksTitle Trypanosoma brucei PTR1 in complex with inhibitor NP-29 ComponentsPteridine reductase Details Keywords OXIDOREDUCTASE / Trypanosoma brucei / pteridine reductase / oxydoreductase / inhibitorFunction / homology Function and homology informationFunction Domain/homology Component
Pteridine reductase / Short-chain dehydrogenase/reductase, conserved site / Short-chain dehydrogenases/reductases family signature. / Enoyl-(Acyl carrier protein) reductase / Short-chain dehydrogenase/reductase SDR / NAD(P)-binding Rossmann-like Domain / NAD(P)-binding domain superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Trypanosoma brucei brucei (eukaryote)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.43 Å DetailsAuthors Landi, G. / Pozzi, C. / Di Pisa, F. / Dello Iacono, L. / Mangani, S. Funding support 1items Details Hide detailsOrganization Grant number Country European Commission 603240
CitationJournal : J.Med.Chem. / Year : 2016Title : Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs.Authors: Borsari, C. / Luciani, R. / Pozzi, C. / Poehner, I. / Henrich, S. / Trande, M. / Cordeiro-da-Silva, A. / Santarem, N. / Baptista, C. / Tait, A. / Di Pisa, F. / Dello Iacono, L. / Landi, G. / ... Authors : Borsari, C. / Luciani, R. / Pozzi, C. / Poehner, I. / Henrich, S. / Trande, M. / Cordeiro-da-Silva, A. / Santarem, N. / Baptista, C. / Tait, A. / Di Pisa, F. / Dello Iacono, L. / Landi, G. / Gul, S. / Wolf, M. / Kuzikov, M. / Ellinger, B. / Reinshagen, J. / Witt, G. / Gribbon, P. / Kohler, M. / Keminer, O. / Behrens, B. / Costantino, L. / Tejera Nevado, P. / Bifeld, E. / Eick, J. / Clos, J. / Torrado, J. / Jimenez-Anton, M.D. / Corral, M.J. / Alunda, J.M. / Pellati, F. / Wade, R.C. / Ferrari, S. / Mangani, S. / Costi, M.P. History Deposition Apr 15, 2016 Deposition site : RCSB / Processing site : PDBERevision 1.0 Aug 17, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Sep 7, 2016 Group : Database referencesRevision 1.2 Jan 31, 2018 Group : Database references / Category : pdbx_related_exp_data_setRevision 1.3 Jan 10, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / diffrn_radiation_wavelength / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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