Entry Database : PDB / ID : 5irl Structure visualization Downloads & linksTitle Crystal structure of rabbit NOD2 SER mutant in an ADP-bound state ComponentsUncharacterized protein Details Keywords IMMUNE SYSTEM / NOD2 / innate immunityFunction / homology Function and homology informationFunction Domain/homology Component
detection of muramyl dipeptide / muramyl dipeptide binding / host-mediated modulation of intestinal microbiota composition / regulation of appetite / intestinal stem cell homeostasis / maintenance of gastrointestinal epithelium / positive regulation of mitophagy / antibacterial innate immune response / positive regulation of B cell activation / positive regulation of protein K63-linked ubiquitination ... detection of muramyl dipeptide / muramyl dipeptide binding / host-mediated modulation of intestinal microbiota composition / regulation of appetite / intestinal stem cell homeostasis / maintenance of gastrointestinal epithelium / positive regulation of mitophagy / antibacterial innate immune response / positive regulation of B cell activation / positive regulation of protein K63-linked ubiquitination / cellular response to muramyl dipeptide / positive regulation of stress-activated MAPK cascade / positive regulation of type 2 immune response / CARD domain binding / positive regulation of cytokine production involved in immune response / peptidoglycan binding / nucleotide-binding oligomerization domain containing 2 signaling pathway / positive regulation of cytokine production involved in inflammatory response / extrinsic component of plasma membrane / temperature homeostasis / pattern recognition receptor activity / positive regulation of interleukin-17 production / response to muramyl dipeptide / canonical NF-kappaB signal transduction / detection of bacterium / phagocytic vesicle / Hsp70 protein binding / ubiquitin binding / positive regulation of interleukin-1 beta production / positive regulation of interleukin-8 production / positive regulation of JNK cascade / Hsp90 protein binding / positive regulation of non-canonical NF-kappaB signal transduction / ADP binding / autophagy / positive regulation of interleukin-6 production / positive regulation of tumor necrosis factor production / actin binding / cellular response to lipopolysaccharide / regulation of inflammatory response / regulation of apoptotic process / basolateral plasma membrane / adaptive immune response / cytoskeleton / positive regulation of canonical NF-kappaB signal transduction / defense response to bacterium / protein kinase binding / protein-containing complex binding / cell surface / Golgi apparatus / positive regulation of transcription by RNA polymerase II / protein-containing complex / mitochondrion / ATP binding / cytosol Similarity search - Function : / NACHT, LRR and PYD domains-containing protein, helical domain HD2 / NLRC4 helical domain HD2 / NOD2, winged helix domain / NOD2 winged helix domain / NACHT nucleoside triphosphatase / NACHT domain / NACHT-NTPase domain profile. / Leucine rich repeat, ribonuclease inhibitor type / Leucine Rich repeat ... : / NACHT, LRR and PYD domains-containing protein, helical domain HD2 / NLRC4 helical domain HD2 / NOD2, winged helix domain / NOD2 winged helix domain / NACHT nucleoside triphosphatase / NACHT domain / NACHT-NTPase domain profile. / Leucine rich repeat, ribonuclease inhibitor type / Leucine Rich repeat / CARD domain / CARD caspase recruitment domain profile. / Caspase recruitment domain / Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) / Ribonuclease Inhibitor / Alpha-Beta Horseshoe / Death-like domain superfamily / Leucine-rich repeat profile. / Leucine-rich repeat / Leucine-rich repeat domain superfamily / P-loop containing nucleotide triphosphate hydrolases / Rossmann fold / P-loop containing nucleoside triphosphate hydrolase / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Oryctolagus cuniculus (rabbit)Method X-RAY DIFFRACTION / SYNCHROTRON / Resolution : 3.09 Å DetailsAuthors Maekawa, S. / Ohto, U. / Shimizu, T. CitationJournal : Nat Commun / Year : 2016Title : Crystal structure of NOD2 and its implications in human disease.Authors : Maekawa, S. / Ohto, U. / Shibata, T. / Miyake, K. / Shimizu, T. History Deposition Mar 14, 2016 Deposition site : RCSB / Processing site : PDBJRevision 1.0 Jun 29, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Feb 19, 2020 Group : Data collection / Derived calculations / Category : diffrn_source / pdbx_struct_oper_listItem : _diffrn_source.pdbx_synchrotron_site / _pdbx_struct_oper_list.symmetry_operationRevision 1.2 Mar 20, 2024 Group : Data collection / Database references / Category : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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