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Open data
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Basic information
Entry | Database: PDB / ID: 5iq5 | |||||||||
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Title | NMR solution structure of Mayaro virus macro domain | |||||||||
![]() | Macro domain | |||||||||
![]() | VIRAL PROTEIN / viral macro domains / Mayaro virus / Alphavirus / ADP ribose binding module | |||||||||
Function / homology | ![]() polynucleotide 5'-phosphatase / : / host cell filopodium / ADP-ribose 1''-phosphate phosphatase / mRNA methyltransferase activity / polynucleotide 5'-phosphatase activity / polynucleotide adenylyltransferase / symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity / 7-methylguanosine mRNA capping / cysteine-type peptidase activity ...polynucleotide 5'-phosphatase / : / host cell filopodium / ADP-ribose 1''-phosphate phosphatase / mRNA methyltransferase activity / polynucleotide 5'-phosphatase activity / polynucleotide adenylyltransferase / symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity / 7-methylguanosine mRNA capping / cysteine-type peptidase activity / Transferases; Transferring one-carbon groups; Methyltransferases / host cell cytoplasmic vesicle membrane / Transferases; Transferring phosphorus-containing groups; Nucleotidyltransferases / nucleoside-triphosphate phosphatase / Hydrolases; Acting on peptide bonds (peptidases); Cysteine endopeptidases / RNA helicase activity / RNA helicase / RNA-directed RNA polymerase / viral RNA genome replication / RNA-dependent RNA polymerase activity / DNA-templated transcription / host cell nucleus / GTP binding / host cell plasma membrane / RNA binding / ATP binding / membrane / metal ion binding Similarity search - Function | |||||||||
Biological species | ![]() | |||||||||
Method | SOLUTION NMR / molecular dynamics | |||||||||
![]() | Melekis, E. / Tsika, A.C. / Bentrop, D. / Papageorgiou, N. / Coutard, B. / Spyroulias, G.A. | |||||||||
Funding support | 2items
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![]() | ![]() Title: Deciphering the Nucleotide and RNA Binding Selectivity of the Mayaro Virus Macro Domain. Authors: Tsika, A.C. / Melekis, E. / Tsatsouli, S.A. / Papageorgiou, N. / Mate, M.J. / Canard, B. / Coutard, B. / Bentrop, D. / Spyroulias, G.A. #1: Journal: Biomol NMR Assign / Year: 2015 Title: NMR study of non-structural proteins--part I: (1)H, (13)C, (15)N backbone and side-chain resonance assignment of macro domain from Mayaro virus (MAYV). Authors: Melekis, E. / Tsika, A.C. / Lichiere, J. / Chasapis, C.T. / Margiolaki, I. / Papageorgiou, N. / Coutard, B. / Bentrop, D. / Spyroulias, G.A. #2: Journal: Biomol NMR Assign / Year: 2015 Title: NMR study of non-structural proteins--part II: (1)H, (13)C, (15)N backbone and side-chain resonance assignment of macro domain from Venezuelan equine encephalitis virus (VEEV). Authors: Makrynitsa, G.I. / Ntonti, D. / Marousis, K.D. / Tsika, A.C. / Lichiere, J. / Papageorgiou, N. / Coutard, B. / Bentrop, D. / Spyroulias, G.A. #3: ![]() Title: Preliminary insights into the non structural protein 3 macro domain of the Mayaro virus by powder diffraction Authors: Papageorgiou, N. / Watier, Y. / Saunders, L. / Coutard, B. / Lantez, V. / Gould, E.A. / Fitch, A.N. / Wright, J.P. / Canard, B. / Margiolaki, I. | |||||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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PDBx/mmCIF format | ![]() | 1.1 MB | Display | ![]() |
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PDB format | ![]() | 932.9 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Summary document | ![]() | 462.1 KB | Display | ![]() |
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Full document | ![]() | 589.8 KB | Display | |
Data in XML | ![]() | 64.6 KB | Display | |
Data in CIF | ![]() | 85.7 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
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Assembly
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NMR ensembles |
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Components
#1: Protein | Mass: 18147.494 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() References: UniProt: Q8QZ73, Transferases; Transferring one-carbon groups; Methyltransferases, Transferases; Transferring phosphorus-containing groups; Nucleotidyltransferases, polynucleotide 5'- ...References: UniProt: Q8QZ73, Transferases; Transferring one-carbon groups; Methyltransferases, Transferases; Transferring phosphorus-containing groups; Nucleotidyltransferases, polynucleotide 5'-phosphatase, Hydrolases; Acting on peptide bonds (peptidases); Cysteine endopeptidases, nucleoside-triphosphate phosphatase, RNA helicase, RNA-directed RNA polymerase |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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NMR experiment |
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Sample preparation
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