Entry Database : PDB / ID : 3v4f Structure visualization Downloads & linksTitle H-Ras PEG 400/CaCl2, ordered off ComponentsGTPase HRas Details Keywords SIGNALING PROTEIN / GTP-BINDING / NUCLEOTIDE BINDINGFunction / homology Function and homology informationFunction Domain/homology Component
Activation of RAS in B cells / SHC1 events in ERBB4 signaling / GRB2 events in EGFR signaling / SHC1 events in EGFR signaling / MET activates RAS signaling / p38MAPK events / GRB2 events in ERBB2 signaling / Tie2 Signaling / SHC-mediated cascade:FGFR1 / FRS-mediated FGFR1 signaling ... Activation of RAS in B cells / SHC1 events in ERBB4 signaling / GRB2 events in EGFR signaling / SHC1 events in EGFR signaling / MET activates RAS signaling / p38MAPK events / GRB2 events in ERBB2 signaling / Tie2 Signaling / SHC-mediated cascade:FGFR1 / FRS-mediated FGFR1 signaling / SHC-mediated cascade:FGFR3 / FRS-mediated FGFR3 signaling / FRS-mediated FGFR4 signaling / SHC-mediated cascade:FGFR4 / FLT3 Signaling / CD209 (DC-SIGN) signaling / SHC-mediated cascade:FGFR2 / FRS-mediated FGFR2 signaling / mitotic cell cycle checkpoint signaling / PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases / EGFR Transactivation by Gastrin / Signaling by SCF-KIT / : / : / Downstream signal transduction / regulation of cell cycle => GO:0051726 / Regulation of RAS by GAPs / DAP12 signaling / VEGFR2 mediated cell proliferation / RAF activation / Estrogen-stimulated signaling through PRKCZ / NCAM signaling for neurite out-growth / Negative regulation of MAPK pathway / FCERI mediated MAPK activation / : / MAP2K and MAPK activation / response to isolation stress / EPHB-mediated forward signaling / positive regulation of Ras protein signal transduction / positive regulation of ruffle assembly / RAF/MAP kinase cascade / regulation of neurotransmitter receptor localization to postsynaptic specialization membrane / negative regulation of GTPase activity / T-helper 1 type immune response / small GTPase-mediated signal transduction / positive regulation of wound healing / positive regulation of miRNA metabolic process / defense response to protozoan / positive regulation of protein targeting to membrane / : / intrinsic apoptotic signaling pathway / small monomeric GTPase / positive regulation of GTPase activity / liver development / positive regulation of DNA replication / positive regulation of epithelial cell proliferation / positive regulation of JNK cascade / regulation of long-term neuronal synaptic plasticity / positive regulation of MAP kinase activity / cellular response to gamma radiation / endocytosis / GDP binding / cellular senescence / positive regulation of type II interferon production / T cell receptor signaling pathway / negative regulation of neuron apoptotic process / Ras protein signal transduction / positive regulation of MAPK cascade / positive regulation of ERK1 and ERK2 cascade / positive regulation of cell migration / positive regulation of protein phosphorylation / negative regulation of cell population proliferation / Golgi membrane / negative regulation of gene expression / intracellular membrane-bounded organelle / GTPase activity / glutamatergic synapse / apoptotic process / positive regulation of cell population proliferation / protein-containing complex binding / positive regulation of gene expression / GTP binding / Golgi apparatus / positive regulation of transcription by RNA polymerase II / nucleoplasm / plasma membrane / cytosol Similarity search - Function Small GTPase, Ras-type / small GTPase Ras family profile. / Small GTPase / Ras family / Small GTP-binding protein domain / P-loop containing nucleotide triphosphate hydrolases / P-loop containing nucleoside triphosphate hydrolase / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 1.391 Å DetailsAuthors Holzapfel, G. / Mattos, C. CitationJournal : Biochemistry / Year : 2012Title : Shift in the Equilibrium between On and Off States of the Allosteric Switch in Ras-GppNHp Affected by Small Molecules and Bulk Solvent Composition.Authors : Holzapfel, G. / Buhrman, G. / Mattos, C. History Deposition Dec 14, 2011 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Aug 8, 2012 Provider : repository / Type : Initial releaseRevision 1.1 Aug 15, 2012 Group : Structure summaryRevision 1.2 Oct 17, 2012 Group : Database referencesRevision 1.3 Nov 8, 2017 Group : Refinement description / Category : software / Item : _software.nameRevision 1.4 Feb 28, 2024 Group : Data collection / Database references / Derived calculationsCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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