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- PDB-3jwq: Crystal structure of chimeric PDE5/PDE6 catalytic domain complexe... -
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Basic information
Entry | Database: PDB / ID: 3jwq | ||||||
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Title | Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with sildenafil | ||||||
![]() | cGMP-specific 3',5'-cyclic phosphodiesterase catalytic domain, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha chimera | ||||||
![]() | HYDROLASE / mostly alpha / Allosteric enzyme / cGMP / cGMP-binding / Magnesium / Metal-binding / Nucleotide-binding / Phosphoprotein / Cell membrane / Lipoprotein / Membrane / Methylation / Prenylation / Sensory transduction / Vision | ||||||
Function / homology | ![]() positive regulation of oocyte development / retinal cone cell development / 3',5'-cyclic-GMP phosphodiesterase / regulation of nitric oxide mediated signal transduction / negative regulation of cardiac muscle contraction / phototransduction, visible light / oocyte development / relaxation of cardiac muscle / RHOBTB1 GTPase cycle / positive regulation of cardiac muscle hypertrophy ...positive regulation of oocyte development / retinal cone cell development / 3',5'-cyclic-GMP phosphodiesterase / regulation of nitric oxide mediated signal transduction / negative regulation of cardiac muscle contraction / phototransduction, visible light / oocyte development / relaxation of cardiac muscle / RHOBTB1 GTPase cycle / positive regulation of cardiac muscle hypertrophy / cGMP catabolic process / cGMP effects / 3',5'-cyclic-nucleotide phosphodiesterase activity / cGMP binding / Smooth Muscle Contraction / 3',5'-cyclic-GMP phosphodiesterase activity / 3',5'-cyclic-AMP phosphodiesterase activity / negative regulation of T cell proliferation / T cell proliferation / visual perception / cAMP-mediated signaling / metal ion binding / plasma membrane / cytosol Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Barren, B. / Gakhar, L. / Muradov, H. / Boyd, K.K. / Ramaswamy, S. / Artemyev, N.O. | ||||||
![]() | ![]() Title: Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit Authors: Barren, B. / Gakhar, L. / Muradov, H. / Boyd, K.K. / Ramaswamy, S. / Artemyev, N.O. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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PDBx/mmCIF format | ![]() | 268 KB | Display | ![]() |
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PDB format | ![]() | 218.8 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | ![]() 3jwrC ![]() 2h42S C: citing same article ( S: Starting model for refinement |
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Similar structure data |
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Assembly
Deposited unit | ![]()
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Component-ID: 1
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