登録情報 | データベース: PDB / ID: 5in3 |
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タイトル | Crystal structure of glucose-1-phosphate bound nucleotidylated human galactose-1-phosphate uridylyltransferase |
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要素 | Galactose-1-phosphate uridylyltransferase |
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キーワード | TRANSFERASE / GALT / UMP-GALT / glucose-1-phosphate / galactose-1-phosphate uridylyltransferase |
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機能・相同性 | 機能・相同性情報
UDP-glucose catabolic process / Defective GALT can cause GALCT / UDP-glucose-hexose-1-phosphate uridylyltransferase / UDP-glucose:hexose-1-phosphate uridylyltransferase activity / galactose catabolic process / Galactose catabolism / UDP-glucose metabolic process / galactose catabolic process via UDP-galactose / galactose metabolic process / Golgi apparatus ...UDP-glucose catabolic process / Defective GALT can cause GALCT / UDP-glucose-hexose-1-phosphate uridylyltransferase / UDP-glucose:hexose-1-phosphate uridylyltransferase activity / galactose catabolic process / Galactose catabolism / UDP-glucose metabolic process / galactose catabolic process via UDP-galactose / galactose metabolic process / Golgi apparatus / zinc ion binding / cytoplasm / cytosol類似検索 - 分子機能 Galactose-1-phosphate uridyl transferase, class I His-active site / Galactose-1-phosphate uridyl transferase family 1 active site signature. / Galactose-1-phosphate uridyl transferase, N-terminal / Galactose-1-phosphate uridyl transferase, C-terminal / Galactose-1-phosphate uridyl transferase, N-terminal domain / Galactose-1-phosphate uridyl transferase, C-terminal domain / Galactose-1-phosphate uridyl transferase, class I / HIT-like / HIT family, subunit A / HIT-like superfamily ...Galactose-1-phosphate uridyl transferase, class I His-active site / Galactose-1-phosphate uridyl transferase family 1 active site signature. / Galactose-1-phosphate uridyl transferase, N-terminal / Galactose-1-phosphate uridyl transferase, C-terminal / Galactose-1-phosphate uridyl transferase, N-terminal domain / Galactose-1-phosphate uridyl transferase, C-terminal domain / Galactose-1-phosphate uridyl transferase, class I / HIT-like / HIT family, subunit A / HIT-like superfamily / 2-Layer Sandwich / Alpha Beta類似検索 - ドメイン・相同性 1-O-phosphono-alpha-D-glucopyranose / 5,6-DIHYDROURIDINE-5'-MONOPHOSPHATE / Galactose-1-phosphate uridylyltransferase類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.73 Å |
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データ登録者 | Kopec, J. / McCorvie, T. / Tallant, C. / Velupillai, S. / Shrestha, L. / Fitzpatrick, F. / Patel, D. / Chalk, R. / Burgess-Brown, N. / von Delft, F. ...Kopec, J. / McCorvie, T. / Tallant, C. / Velupillai, S. / Shrestha, L. / Fitzpatrick, F. / Patel, D. / Chalk, R. / Burgess-Brown, N. / von Delft, F. / Arrowsmith, C. / Edwards, A. / Bountra, C. / Yue, W.W. |
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資金援助 | 英国, 1件 組織 | 認可番号 | 国 |
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Wellcome Trust | 092809/Z/10/Z | 英国 |
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引用 | ジャーナル: Hum.Mol.Genet. / 年: 2016 タイトル: Molecular basis of classic galactosemia from the structure of human galactose 1-phosphate uridylyltransferase. 著者: McCorvie, T.J. / Kopec, J. / Pey, A.L. / Fitzpatrick, F. / Patel, D. / Chalk, R. / Shrestha, L. / Yue, W.W. |
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履歴 | 登録 | 2016年3月7日 | 登録サイト: RCSB / 処理サイト: PDBE |
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改定 1.0 | 2016年3月30日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2016年9月14日 | Group: Database references |
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改定 1.2 | 2016年11月9日 | Group: Database references |
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改定 1.3 | 2017年8月30日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.4 | 2019年10月16日 | Group: Data collection / カテゴリ: reflns / reflns_shell Item: _reflns.pdbx_CC_half / _reflns_shell.number_unique_obs / _reflns_shell.pdbx_CC_half |
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改定 1.5 | 2020年7月29日 | Group: Data collection / Derived calculations / Structure summary カテゴリ: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_site / struct_site_gen Item: _chem_comp.mon_nstd_flag / _chem_comp.name ..._chem_comp.mon_nstd_flag / _chem_comp.name / _entity.pdbx_description / _pdbx_entity_nonpoly.name 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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改定 1.6 | 2024年1月10日 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ..._chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id |
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