Entry Database : PDB / ID : 5ic1 Structure visualization Downloads & linksTitle Structural analysis of a talin triple domain module, E1794Y, E1797Y, Q1801Y mutant ComponentsTalin-1 Details Keywords PEPTIDE BINDING PROTEIN / Integrin / RIAM / autoinhibition / alternativeFunction / homology Function and homology informationFunction Domain/homology Component
GRB2:SOS provides linkage to MAPK signaling for Integrins / Integrin signaling / Smooth Muscle Contraction / p130Cas linkage to MAPK signaling for integrins / SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion / MAP2K and MAPK activation / LIM domain binding / Platelet degranulation / vinculin binding / integrin activation ... GRB2:SOS provides linkage to MAPK signaling for Integrins / Integrin signaling / Smooth Muscle Contraction / p130Cas linkage to MAPK signaling for integrins / SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion / MAP2K and MAPK activation / LIM domain binding / Platelet degranulation / vinculin binding / integrin activation / cell-substrate junction assembly / cortical actin cytoskeleton organization / phosphatidylserine binding / ruffle / phosphatidylinositol binding / integrin-mediated signaling pathway / adherens junction / structural constituent of cytoskeleton / ruffle membrane / cell-cell adhesion / actin filament binding / integrin binding / cytoskeleton / focal adhesion / cell surface / plasma membrane / cytoplasm Similarity search - Function : / Talin, R4 domain / Vinculin-binding site-containing domain / Talin, central / Talin, N-terminal F0 domain / Talin, central domain superfamily / Talin-1/2, rod-segment / Vinculin Binding Site / Talin, middle domain / N-terminal or F0 domain of Talin-head FERM ... : / Talin, R4 domain / Vinculin-binding site-containing domain / Talin, central / Talin, N-terminal F0 domain / Talin, central domain superfamily / Talin-1/2, rod-segment / Vinculin Binding Site / Talin, middle domain / N-terminal or F0 domain of Talin-head FERM / I/LWEQ domain / I/LWEQ domain superfamily / I/LWEQ domain / I/LWEQ domain profile. / I/LWEQ domain / Phosphotyrosine-binding domain / Alpha-catenin/vinculin-like superfamily / FERM domain signature 1. / FERM conserved site / FERM domain signature 2. / FERM central domain / FERM/acyl-CoA-binding protein superfamily / FERM central domain / FERM superfamily, second domain / FERM domain / FERM domain profile. / Band 4.1 domain / Band 4.1 homologues / PH-like domain superfamily / Ubiquitin-like domain superfamily Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.2 Å DetailsAuthors Wu, J. / Chang, Y.-C.E. / Zhang, H. / Huang, Q.-Q. Funding support United States, 3items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Cancer Institute (NIH/NCI) CA006927 United States Pennsylvania Department of Health 4100068716, ACS RSG-15-167-01-DMC United States CCSG Supported Pilot Projects award 5P30CA006927-51 United States
CitationJournal : Structure / Year : 2016Title : Structural and Functional Analysis of a Talin Triple-Domain Module Suggests an Alternative Talin Autoinhibitory Configuration.Authors : Zhang, H. / Chang, Y.C. / Huang, Q. / Brennan, M.L. / Wu, J. History Deposition Feb 22, 2016 Deposition site : RCSB / Processing site : RCSBRevision 1.0 May 18, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Sep 20, 2017 Group : Author supporting evidence / Database references / Derived calculationsCategory : citation / pdbx_audit_support / pdbx_struct_oper_listItem : _citation.journal_id_CSD / _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operationRevision 1.2 Dec 4, 2019 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.3 Sep 27, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / diffrn_radiation_wavelength / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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