Entry Database : PDB / ID : 5hq3 Structure visualization Downloads & linksTitle Stable, high-expression variant of human acetylcholinesterase Components(Acetylcholinesterase) x 2 Details Keywords HYDROLASE / Design / De Novo ProteinFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of synaptic transmission, cholinergic / Neurotransmitter clearance / acetylcholine catabolic process in synaptic cleft / cholinesterase activity / serine hydrolase activity / acetylcholine catabolic process / acetylcholine binding / acetylcholinesterase / amyloid precursor protein metabolic process / acetylcholine receptor signaling pathway ... negative regulation of synaptic transmission, cholinergic / Neurotransmitter clearance / acetylcholine catabolic process in synaptic cleft / cholinesterase activity / serine hydrolase activity / acetylcholine catabolic process / acetylcholine binding / acetylcholinesterase / amyloid precursor protein metabolic process / acetylcholine receptor signaling pathway / osteoblast development / acetylcholinesterase activity / Synthesis of PC / basement membrane / regulation of receptor recycling / Synthesis, secretion, and deacylation of Ghrelin / side of membrane / synaptic cleft / laminin binding / collagen binding / synapse assembly / positive regulation of protein secretion / neuromuscular junction / receptor internalization / retina development in camera-type eye / nervous system development / positive regulation of cold-induced thermogenesis / amyloid-beta binding / cell adhesion / hydrolase activity / synapse / perinuclear region of cytoplasm / Golgi apparatus / cell surface / protein homodimerization activity / extracellular space / extracellular region / membrane / nucleus / plasma membrane Similarity search - Function Acetylcholinesterase, tetramerisation domain / Acetylcholinesterase tetramerisation domain / : / Cholinesterase / Carboxylesterase type B, conserved site / Carboxylesterases type-B signature 2. / Carboxylesterase type B, active site / Carboxylesterases type-B serine active site. / Carboxylesterase, type B / Carboxylesterase family ... Acetylcholinesterase, tetramerisation domain / Acetylcholinesterase tetramerisation domain / : / Cholinesterase / Carboxylesterase type B, conserved site / Carboxylesterases type-B signature 2. / Carboxylesterase type B, active site / Carboxylesterases type-B serine active site. / Carboxylesterase, type B / Carboxylesterase family / Alpha/Beta hydrolase fold, catalytic domain / Alpha/Beta hydrolase fold / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.6 Å DetailsAuthors Goldenzweig, A. / Goldsmith, M. / Hill, S.E. / Gertman, O. / Laurino, P. / Ashani, Y. / Dym, O. / Albeck, S. / Unger, T. / Prilusky, J. ...Goldenzweig, A. / Goldsmith, M. / Hill, S.E. / Gertman, O. / Laurino, P. / Ashani, Y. / Dym, O. / Albeck, S. / Unger, T. / Prilusky, J. / Lieberman, R.L. / Aharoni, A. / Silman, I. / Sussman, J.L. / Tawfik, D.S. / Fleishman, S.J. CitationJournal : Mol.Cell / Year : 2016Title : Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.Authors: Goldenzweig, A. / Goldsmith, M. / Hill, S.E. / Gertman, O. / Laurino, P. / Ashani, Y. / Dym, O. / Unger, T. / Albeck, S. / Prilusky, J. / Lieberman, R.L. / Aharoni, A. / Silman, I. / ... Authors : Goldenzweig, A. / Goldsmith, M. / Hill, S.E. / Gertman, O. / Laurino, P. / Ashani, Y. / Dym, O. / Unger, T. / Albeck, S. / Prilusky, J. / Lieberman, R.L. / Aharoni, A. / Silman, I. / Sussman, J.L. / Tawfik, D.S. / Fleishman, S.J. History Deposition Jan 21, 2016 Deposition site : RCSB / Processing site : PDBERevision 1.0 Jul 27, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Aug 3, 2016 Group : Database referencesRevision 1.2 Aug 23, 2017 Group : Structure summary / Category : pdbx_entry_details / struct_keywordsItem : _struct_keywords.pdbx_keywords / _struct_keywords.textRevision 1.3 Nov 8, 2017 Group : Database references / Source and taxonomy / Structure summaryCategory : entity / entity_name_com ... entity / entity_name_com / entity_src_gen / struct / struct_ref / struct_ref_seq / struct_ref_seq_dif Item : _entity.pdbx_description / _entity.pdbx_ec ... _entity.pdbx_description / _entity.pdbx_ec / _entity_src_gen.pdbx_gene_src_gene / _struct.title / _struct_ref.db_code / _struct_ref.db_name / _struct_ref.pdbx_align_begin / _struct_ref.pdbx_db_accession / _struct_ref.pdbx_seq_one_letter_code / _struct_ref_seq.db_align_beg / _struct_ref_seq.db_align_end / _struct_ref_seq.pdbx_auth_seq_align_beg / _struct_ref_seq.pdbx_db_accession / _struct_ref_seq.seq_align_beg Revision 1.4 Jan 10, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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