登録情報 | データベース: PDB / ID: 5eyp |
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タイトル | TUBULIN-DARPIN COMPLEX |
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要素 | - DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN)
- Tubulin alpha chain
- Tubulin beta chain
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キーワード | CELL CYCLE / DARPIN / MICROTUBULE / TUBULIN / PROTEIN BINDING |
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機能・相同性 | 機能・相同性情報
axonemal microtubule / organelle transport along microtubule / forebrain morphogenesis / glial cell differentiation / cerebellar cortex morphogenesis / dentate gyrus development / neuron projection arborization / flagellated sperm motility / centrosome cycle / pyramidal neuron differentiation ...axonemal microtubule / organelle transport along microtubule / forebrain morphogenesis / glial cell differentiation / cerebellar cortex morphogenesis / dentate gyrus development / neuron projection arborization / flagellated sperm motility / centrosome cycle / pyramidal neuron differentiation / response to L-glutamate / smoothened signaling pathway / regulation of synapse organization / startle response / motor behavior / locomotory exploration behavior / microtubule polymerization / response to tumor necrosis factor / sperm flagellum / response to mechanical stimulus / microtubule-based process / condensed chromosome / homeostasis of number of cells within a tissue / cellular response to calcium ion / adult locomotory behavior / intracellular protein transport / synapse organization / cerebral cortex development / neuromuscular junction / visual learning / recycling endosome / structural constituent of cytoskeleton / cytoplasmic ribonucleoprotein granule / memory / neuron migration / neuron apoptotic process / microtubule / gene expression / hydrolase activity / protein heterodimerization activity / GTPase activity / protein-containing complex binding / GTP binding / metal ion binding / identical protein binding / plasma membrane / cytosol / cytoplasm類似検索 - 分子機能 Helix hairpin bin / Ankyrin repeat-containing domain / Tubulin/FtsZ, C-terminal domain / Tubulin/FtsZ, GTPase domain / 60s Ribosomal Protein L30; Chain: A; / Tubulin-beta mRNA autoregulation signal. / Alpha tubulin / Beta tubulin, autoregulation binding site / Beta tubulin / Tubulin ...Helix hairpin bin / Ankyrin repeat-containing domain / Tubulin/FtsZ, C-terminal domain / Tubulin/FtsZ, GTPase domain / 60s Ribosomal Protein L30; Chain: A; / Tubulin-beta mRNA autoregulation signal. / Alpha tubulin / Beta tubulin, autoregulation binding site / Beta tubulin / Tubulin / Tubulin, C-terminal / Tubulin C-terminal domain / Tubulin, conserved site / Tubulin subunits alpha, beta, and gamma signature. / Tubulin/FtsZ family, C-terminal domain / Tubulin/FtsZ-like, C-terminal domain / Tubulin/FtsZ, C-terminal / Tubulin/FtsZ, 2-layer sandwich domain / Tubulin/FtsZ family, GTPase domain / Tubulin/FtsZ family, GTPase domain / Tubulin/FtsZ, GTPase domain / Tubulin/FtsZ, GTPase domain superfamily / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Helix Hairpins / Alpha Horseshoe / Rossmann fold / 2-Layer Sandwich / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 GUANOSINE-5'-DIPHOSPHATE / GUANOSINE-5'-TRIPHOSPHATE / Chem-LOC / Tubulin beta chain / Tubulin alpha chain類似検索 - 構成要素 |
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生物種 | synthetic construct (人工物)
 Ovis aries (ヒツジ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.9 Å |
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データ登録者 | Ahmad, S. / Knossow, M. / Gigant, B. |
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資金援助 | フランス, 1件 組織 | 認可番号 | 国 |
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French National Research Agency | ANR-12-BSV8-0002-01 | フランス |
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引用 | ジャーナル: Sci Rep / 年: 2016 タイトル: Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin. 著者: Ahmad, S. / Pecqueur, L. / Dreier, B. / Hamdane, D. / Aumont-Nicaise, M. / Pluckthun, A. / Knossow, M. / Gigant, B. |
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履歴 | 登録 | 2015年11月25日 | 登録サイト: RCSB / 処理サイト: PDBE |
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改定 1.0 | 2016年7月20日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年9月6日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.2 | 2024年1月10日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr2_auth_seq_id |
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