- PDB-5ek0: Human Nav1.7-VSD4-NavAb in complex with GX-936. -
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Basic information
Entry
Database: PDB / ID: 5ek0
Title
Human Nav1.7-VSD4-NavAb in complex with GX-936.
Components
Chimera of bacterial Ion transport protein and human Sodium channel protein type 9 subunit alpha
Keywords
METAL TRANSPORT / membrane protein / ion channel / voltage-gated sodium channel / small molecule antagonist
Function / homology
Function and homology information
detection of mechanical stimulus involved in sensory perception / membrane depolarization during action potential / cardiac muscle cell action potential involved in contraction / voltage-gated sodium channel complex / Interaction between L1 and Ankyrins / voltage-gated sodium channel activity / sodium ion transport / Phase 0 - rapid depolarisation / behavioral response to pain / detection of temperature stimulus involved in sensory perception of pain ...detection of mechanical stimulus involved in sensory perception / membrane depolarization during action potential / cardiac muscle cell action potential involved in contraction / voltage-gated sodium channel complex / Interaction between L1 and Ankyrins / voltage-gated sodium channel activity / sodium ion transport / Phase 0 - rapid depolarisation / behavioral response to pain / detection of temperature stimulus involved in sensory perception of pain / sodium ion transmembrane transport / sensory perception of pain / post-embryonic development / response to toxic substance / Sensory perception of sweet, bitter, and umami (glutamate) taste / circadian rhythm / inflammatory response / axon / identical protein binding / metal ion binding / plasma membrane Similarity search - Function
Voltage-gated potassium channels. Chain C / Voltage-gated Na+ ion channel, cytoplasmic domain / Cytoplasmic domain of voltage-gated Na+ ion channel / Voltage-gated sodium channel alpha subunit, inactivation gate / Sodium ion transport-associated / Sodium ion transport-associated / Voltage gated sodium channel, alpha subunit / Voltage-gated cation channel calcium and sodium / Helix Hairpins - #70 / Short calmodulin-binding motif containing conserved Ile and Gln residues. ...Voltage-gated potassium channels. Chain C / Voltage-gated Na+ ion channel, cytoplasmic domain / Cytoplasmic domain of voltage-gated Na+ ion channel / Voltage-gated sodium channel alpha subunit, inactivation gate / Sodium ion transport-associated / Sodium ion transport-associated / Voltage gated sodium channel, alpha subunit / Voltage-gated cation channel calcium and sodium / Helix Hairpins - #70 / Short calmodulin-binding motif containing conserved Ile and Gln residues. / IQ motif, EF-hand binding site / Voltage-dependent channel domain superfamily / Four Helix Bundle (Hemerythrin (Met), subunit A) / Ion transport domain / Ion transport protein / Helix Hairpins / Up-down Bundle / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homology
Chem-5P2 / 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE / Ion transport protein / Sodium channel protein type 9 subunit alpha Similarity search - Component
Biological species
Arcobacter butzleri (bacteria) Homo sapiens (human)
A: Chimera of bacterial Ion transport protein and human Sodium channel protein type 9 subunit alpha B: Chimera of bacterial Ion transport protein and human Sodium channel protein type 9 subunit alpha C: Chimera of bacterial Ion transport protein and human Sodium channel protein type 9 subunit alpha D: Chimera of bacterial Ion transport protein and human Sodium channel protein type 9 subunit alpha hetero molecules
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