PDB-5ehd: Crystal structure of human nucleophosmin-core in complex with cyt...

Basic information

• Entry: Database: PDB / ID: 5ehd
• Title: Crystal structure of human nucleophosmin-core in complex with cytochrome c
• Components: Nucleophosmin
• Keywords: OXIDOREDUCTASE / nucleolus / histone assembly / citochrome c / apoptosis

Function / homology

Function:

regulation of mRNA stability involved in cellular response to UV / regulation of eIF2 alpha phosphorylation by dsRNA / regulation of endoribonuclease activity / negative regulation of centrosome duplication / positive regulation of cell cycle G2/M phase transition / regulation of endodeoxyribonuclease activity / regulation of centriole replication / granular component / negative regulation of protein kinase activity by regulation of protein phosphorylation / TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation / SARS-CoV-1-host interactions / regulation of centrosome duplication / Tat protein binding / spindle pole centrosome / ALK mutants bind TKIs / Nuclear import of Rev protein / centrosome cycle / TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain / nucleocytoplasmic transport / protein kinase inhibitor activity / ribosomal large subunit binding / macrophage differentiation / ribosomal small subunit binding / ribosomal large subunit export from nucleus / NF-kappaB binding / core promoter sequence-specific DNA binding / Nuclear events stimulated by ALK signaling in cancer / ribosomal small subunit export from nucleus / Deposition of new CENPA-containing nucleosomes at the centromere / SUMOylation of transcription cofactors / ribosome assembly / ribosomal large subunit biogenesis / positive regulation of translation / intracellular protein transport / protein-DNA complex / PKR-mediated signaling / protein import into nucleus / positive regulation of NF-kappaB transcription factor activity / cellular response to UV / cellular senescence / Signaling by ALK fusions and activated point mutants / unfolded protein binding / intracellular protein localization / nucleosome assembly / ribosomal small subunit biogenesis / DNA-binding transcription factor binding / molecular adaptor activity / histone binding / transcription coactivator activity / rRNA binding / chromatin remodeling / ribonucleoprotein complex / negative regulation of cell population proliferation / focal adhesion / DNA repair / positive regulation of cell population proliferation / centrosome / chromatin binding / negative regulation of apoptotic process / protein kinase binding / positive regulation of DNA-templated transcription / nucleolus / signal transduction / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / protein-containing complex / RNA binding / nucleoplasm / nucleus / membrane / cytosol / cytoplasm

Domain/homology:

Nucleoplasmin core domain / Nucleophosmin, C-terminal / Nucleophosmin C-terminal domain / Nucleoplasmin core domain / Nucleoplasmin core domain superfamily / Nucleoplasmin/nucleophosmin domain / Nucleoplasmin family / Jelly Rolls / Sandwich / Mainly Beta

Component:

Nucleophosmin

• Biological species: Homo sapiens (human)
• Method: X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.55 Å
• Authors: Bernardo-Garcia, N. / Hermoso, J.A. / Gonzalez-Arzola, K. / Diaz-Moreno, I. / De la Rosa, M.A.
• Citation: Journal: To Be Published; Title: Crystal structure of human nucleophosmin-core in complex with cytochrome c; Authors: Bernardo-Garcia, N. / Hermoso, J.A. / Gonzalez-Arzola, K. / Diaz-Moreno, I. / De la Rosa, M.A.

History

Deposition	Oct 28, 2015	Deposition site: RCSB / Processing site: PDBE
Revision 1.0	Nov 9, 2016	Provider: repository / Type: Initial release
Revision 1.1	Jan 10, 2024	Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession

Assembly

Deposited unit

A: Nucleophosmin

B: Nucleophosmin

C: Nucleophosmin

D: Nucleophosmin

E: Nucleophosmin

F: Nucleophosmin

G: Nucleophosmin

H: Nucleophosmin

I: Nucleophosmin

J: Nucleophosmin

a: Nucleophosmin

b: Nucleophosmin

c: Nucleophosmin

d: Nucleophosmin

e: Nucleophosmin

f: Nucleophosmin

g: Nucleophosmin

h: Nucleophosmin

i: Nucleophosmin

j: Nucleophosmin

hetero molecules

Summary:

• 254 kDa, 20 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	253,609	24
Polymers	253,467	20
Non-polymers	142	4
Water	4,234	235

1

A: Nucleophosmin

B: Nucleophosmin

C: Nucleophosmin

D: Nucleophosmin

E: Nucleophosmin

hetero molecules

Summary:

• defined by software
• 63.4 kDa, 5 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	63,402	6
Polymers	63,367	5
Non-polymers	35	1
Water	90	5

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	10410 Å2
ΔGint	-69 kcal/mol
Surface area	20810 Å2
Method	PISA

2

F: Nucleophosmin

G: Nucleophosmin

H: Nucleophosmin

I: Nucleophosmin

J: Nucleophosmin

hetero molecules

Summary:

• defined by software
• 63.4 kDa, 5 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	63,402	6
Polymers	63,367	5
Non-polymers	35	1
Water	90	5

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	10340 Å2
ΔGint	-74 kcal/mol
Surface area	21320 Å2
Method	PISA

3

a: Nucleophosmin

b: Nucleophosmin

c: Nucleophosmin

d: Nucleophosmin

e: Nucleophosmin

hetero molecules

Summary:

• defined by software
• 63.4 kDa, 5 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	63,402	6
Polymers	63,367	5
Non-polymers	35	1
Water	90	5

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	10200 Å2
ΔGint	-73 kcal/mol
Surface area	20770 Å2
Method	PISA

4

f: Nucleophosmin

g: Nucleophosmin

h: Nucleophosmin

i: Nucleophosmin

j: Nucleophosmin

hetero molecules

Summary:

• defined by software
• 63.4 kDa, 5 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	63,402	6
Polymers	63,367	5
Non-polymers	35	1
Water	90	5

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Calculated values:

Buried area	10400 Å2
ΔGint	-71 kcal/mol
Surface area	20750 Å2
Method	PISA

Unit cell

Length a, b, c (Å)	58.799, 179.720, 104.300
Angle α, β, γ (deg.)	90.00, 94.32, 90.00
Int Tables number	4
Space group name H-M	P1211

Components

#1: Protein

A B C D E F G H I J a b c d e f g h i j
Nucleophosmin / NPM / Nucleolar phosphoprotein B23 / Nucleolar protein NO38 / Numatrin

Details:

Mass: 12673.365 Da / Num. of mol.: 20
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: NPM1, NPM / Plasmid: pET21a / Production host: Escherichia coli BL21(DE3) (bacteria) / References: UniProt: P06748

#2: Chemical

A-201 G-201 b-201 f-201
ChemComp-CL / CHLORIDE ION

Details:

Mass: 35.453 Da / Num. of mol.: 4 / Source method: obtained synthetically / Formula: Cl

#3: Water

ChemComp-HOH / water

Details:

Mass: 18.015 Da / Num. of mol.: 235 / Source method: isolated from a natural source / Formula: H₂O

Experimental details

Experiment

• Experiment: Method: X-RAY DIFFRACTION

Sample preparation

• Crystal: Density Matthews: 2.16 ų/Da / Density % sol: 42.97 %
• Crystal grow: Temperature: 290 K / Method: vapor diffusion, sitting drop / Details: 25% PEG 400, 0.1 M MES, 0.1 M MgCl2 / PH range: 7

Data collection

• Diffraction: Mean temperature: 100 K
• Diffraction source: Source: SYNCHROTRON / Site: ALBA / Beamline: XALOC / Wavelength: 0.97946 Å
• Detector: Type: PSI PILATUS 6M / Detector: PIXEL / Date: Dec 17, 2014
• Radiation: Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
• Radiation wavelength: Wavelength: 0.97946 Å / Relative weight: 1
• Reflection: Resolution: 2.55→45.53 Å / Num. obs: 69833 / % possible obs: 99.6 % / Redundancy: 6.3 % / R_merge(I) obs: 0.126 / Net I/σ(I): 9.6
• Reflection shell: Resolution: 2.55→2.61 Å / R_merge(I) obs: 0.048 / Num. unique all: 4237

Processing

Software

Name	Version	Classification
PHENIX	(1.10_2155: 000)	refinement
iMOSFLM		data reduction
Aimless		data scaling
Coot		model building

Refinement

Method to determine structure: MOLECULAR REPLACEMENT
Starting model: 2P1B

2p1b

Resolution: 2.55→45.526 Å / SU ML: 0.31 / Cross valid method: FREE R-VALUE / σ(F): 1.34 / Phase error: 23.59 / Stereochemistry target values: ML

	Rfactor	Num. reflection	% reflection
Rfree	0.2291	4137	5.02 %
Rwork	0.1636	-	-
obs	0.1668	82338	99.52 %

• Solvent computation: Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL

Refinement step

Cycle: LAST / Resolution: 2.55→45.526 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	16213	0	4	235	16452

Refine LS restraints

Refine-ID	Type	Dev ideal	Number
X-RAY DIFFRACTION	f_bond_d	0.009	16533
X-RAY DIFFRACTION	f_angle_d	1.265	22397
X-RAY DIFFRACTION	f_dihedral_angle_d	17.514	9998
X-RAY DIFFRACTION	f_chiral_restr	0.067	2580
X-RAY DIFFRACTION	f_plane_restr	0.007	2904

LS refinement shell

Resolution (Å)	Rfactor Rfree	Num. reflection Rfree	Rfactor Rwork	Num. reflection Rwork	Refine-ID	% reflection obs (%)
2.413-2.4404	0.331	146	0.2739	2582	X-RAY DIFFRACTION	99
2.4404-2.4691	0.3653	150	0.2705	2597	X-RAY DIFFRACTION	99
2.4691-2.4992	0.351	160	0.2779	2545	X-RAY DIFFRACTION	100
2.4992-2.5309	0.3012	156	0.2611	2596	X-RAY DIFFRACTION	99
2.5309-2.5642	0.3061	140	0.2443	2620	X-RAY DIFFRACTION	99
2.5642-2.5993	0.3019	139	0.244	2550	X-RAY DIFFRACTION	100
2.5993-2.6364	0.3429	145	0.2292	2607	X-RAY DIFFRACTION	100
2.6364-2.6758	0.2778	132	0.2223	2651	X-RAY DIFFRACTION	99
2.6758-2.7176	0.3112	145	0.2224	2524	X-RAY DIFFRACTION	99
2.7176-2.7621	0.2861	127	0.2229	2631	X-RAY DIFFRACTION	100
2.7621-2.8097	0.3033	143	0.2164	2626	X-RAY DIFFRACTION	100
2.8097-2.8608	0.2323	155	0.193	2569	X-RAY DIFFRACTION	100
2.8608-2.9158	0.2583	130	0.1987	2593	X-RAY DIFFRACTION	99
2.9158-2.9753	0.2398	146	0.1903	2615	X-RAY DIFFRACTION	100
2.9753-3.04	0.2777	160	0.1846	2531	X-RAY DIFFRACTION	99
3.04-3.1107	0.2695	153	0.1908	2638	X-RAY DIFFRACTION	99
3.1107-3.1885	0.2351	102	0.1803	2583	X-RAY DIFFRACTION	99
3.1885-3.2747	0.2444	140	0.1742	2637	X-RAY DIFFRACTION	99
3.2747-3.371	0.2587	123	0.1781	2600	X-RAY DIFFRACTION	99
3.371-3.4798	0.2151	141	0.1701	2629	X-RAY DIFFRACTION	99
3.4798-3.6041	0.2544	126	0.1633	2604	X-RAY DIFFRACTION	100
3.6041-3.7483	0.201	152	0.1457	2595	X-RAY DIFFRACTION	100
3.7483-3.9189	0.1935	131	0.1367	2631	X-RAY DIFFRACTION	100
3.9189-4.1253	0.2083	125	0.1347	2613	X-RAY DIFFRACTION	100
4.1253-4.3836	0.1861	112	0.1241	2624	X-RAY DIFFRACTION	100
4.3836-4.7217	0.178	129	0.1074	2643	X-RAY DIFFRACTION	100
4.7217-5.1963	0.1635	115	0.1125	2644	X-RAY DIFFRACTION	100
5.1963-5.9468	0.2254	119	0.1504	2650	X-RAY DIFFRACTION	100
5.9468-7.487	0.2181	156	0.1525	2620	X-RAY DIFFRACTION	100
7.487-45.5343	0.1589	139	0.1454	2653	X-RAY DIFFRACTION	99

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°2)	L12 (°2)	L13 (°2)	L22 (°2)	L23 (°2)	L33 (°2)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å2)	T12 (Å2)	T13 (Å2)	T22 (Å2)	T23 (Å2)	T33 (Å2)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	5.4041	5.4269	1.6912	5.236	3.1071	9.0241	0.4585	-1.201	-0.2261	1.2864	-0.4636	0.3858	0.8303	-0.1354	-0.1733	0.592	0.1474	0.1561	0.6228	0.078	0.5598	-43.9481	-31.5593	115.4197
2	7.5642	1.9636	-2.1983	5.7555	-5.8346	5.8207	-0.1332	-1.8164	0.3833	1.1461	0.666	0.0579	-1.2681	0.0122	-0.5983	0.627	0.0087	0.0695	0.7541	-0.1145	0.4762	-36.4426	-20.9403	121.1612
3	6.1894	2.2775	-3.189	1.4936	-0.5795	4.5975	-0.0965	-1.9613	-1.5435	2.7878	0.4026	0.0795	1.9842	0.6299	-0.2409	1.6547	-0.0305	0.382	1.3609	0.4988	1.3427	-41.6722	-38.9526	128.1604
4	4.2259	1.0524	-0.1794	3.0504	-2.5975	6.1791	0.0881	-0.2229	0.1697	0.5929	0.3768	0.7308	-0.1596	-0.019	-0.5137	0.3094	0.0645	0.066	0.4177	0.0116	0.3446	-35.8061	-23.5759	109.8495
5	3.6839	2.6306	-1.8176	3.5461	0.4554	2.9284	-1.568	-1.3574	-0.0926	1.2261	0.453	-2.4435	-0.3978	0.2502	1.0243	0.4755	0.1891	0.0039	0.685	0.0759	0.4393	-27.8371	-25.4051	117.0309
6	1.3788	-0.5663	2.1874	5.4601	-3.7707	4.1279	-0.2284	-0.1438	-0.0213	0.2522	0.0111	-0.3275	-0.063	0.2027	0.1913	0.414	0.1235	0.0744	0.4568	0.0278	0.2933	-27.8898	-27.3923	111.048
7	2.5433	-1.0004	0.7226	3.355	-4.4489	5.6027	0.1549	-0.4562	0.1195	0.5506	-0.1159	0.2653	0.3449	0.2024	0.0033	0.5147	0.0292	0.0246	0.5099	0.0009	0.2448	-31.8073	-26.0992	116.9917
8	6.3502	1.9018	-2.014	9.6237	-4.5095	9.8508	0.2786	-0.6992	-0.5916	-0.2105	-0.2351	0.6244	0.6013	0.4335	-0.073	0.4389	0.0499	0.0346	0.4266	0.0626	0.3876	-41.4843	-33.1705	115.0303
9	8.1778	3.5874	-1.4266	6.2969	-1.409	2.1323	0.516	-0.627	-0.3557	0.5462	-0.748	-0.4071	0.1979	0.2831	0.2301	0.54	0.1008	-0.0375	0.618	0.0679	0.2694	-23.3941	-36.8393	115.8844
10	5.6272	-2.7962	3.5987	3.1352	-4.5694	6.9771	-0.714	-0.9019	0.8995	0.9747	-0.0301	-1.5051	-0.5587	0.8552	0.6617	0.5763	0.046	-0.1328	0.9772	0.0288	0.6927	-10.4073	-32.3317	111.2764
11	4.3813	2.8516	-2.1675	2.7325	1.6091	2.0007	0.4227	-0.8704	-2.1318	1.603	-0.0611	-2.2909	-0.2247	1.4873	0.9277	1.235	0.0434	-0.2001	1.407	0.1765	1.0278	-16.9026	-49.0505	119.7513
12	2.7977	0.3625	-1.0681	8.5763	-1.7193	4.6574	0.0819	0.2024	-0.1098	0.5754	-0.3997	-0.4508	0.248	0.6547	0.2344	0.4113	0.0881	-0.0487	0.5222	-0.0101	0.2231	-20.4793	-29.2288	106.1178
13	5.3943	-0.3507	0.1072	4.7103	-5.8326	7.1605	0.3707	-1.2299	-0.1891	-1.0292	0.073	-0.9005	1.4867	1.5569	-0.2051	0.6295	0.2763	-0.0616	0.7044	0.1549	0.3243	-13.1439	-35.8923	102.1116
14	4.4695	2.8133	0.7593	7.8757	-1.2508	3.6078	-0.2846	0.016	-0.9874	0.0079	0.2581	-0.5669	1.0381	0.6554	0.0735	0.7374	0.1781	0.1012	0.6913	0.0861	0.5055	-14.0528	-42.1885	99.0656
15	5.651	2.181	-4.7198	3.3105	-0.2594	5.071	0.3582	-0.655	0.1259	1.2568	-0.0111	0.5854	-0.6323	0.3187	-0.6204	0.4363	-0.0524	0.0688	0.3719	-0.0019	0.3787	-22.9957	-20.5189	98.1687
16	7.435	3.6039	-2.7573	2.5462	-2.9152	4.3133	0.5316	-0.0466	0.5426	-0.8455	0.4018	-0.0601	1.5064	0.5547	-0.6374	0.7002	0.1702	-0.0721	0.3898	0.0234	0.2524	-27.1216	-32.5695	102.7609
17	2.0242	-5.888	6.625	4.6887	-1.0138	5.686	-0.4547	-1.4819	-1.0451	0.8807	0.3092	0.086	-0.2754	-0.2877	0.153	0.7785	0.1652	-0.0811	0.6243	0.1614	0.4481	-19.7584	-44.1408	107.1754
18	5.9871	1.6886	-1.1619	8.3866	-4.68	5.2039	-0.193	0.0781	-0.1422	0.0156	0.093	-0.3689	0.3081	0.5763	0.15	0.4118	0.0482	-0.0379	0.5146	-0.0334	0.2434	-17.3518	-33.5921	108.6482
19	4.4166	-0.4592	0.5842	3.1683	-0.617	3.6112	-0.4068	-0.8038	-0.8993	-0.3479	-0.4536	-0.8267	1.379	0.6066	0.8334	0.9491	0.2063	0.0763	0.4465	-0.0018	0.4608	-19.6213	-47.4131	98.8356
20	6.9491	-1.0938	0.9971	1.0154	1.0543	1.7852	-0.49	0.9623	-1.9192	-0.4905	0.6301	-0.3924	2.1925	-0.11	0.1776	1.63	0.3657	0.1772	0.9413	-0.269	1.149	-16.6372	-51.1184	87.9896
21	7.6217	-1.7611	-1.4043	1.3511	-1.771	5.8032	0.2086	-0.3914	-0.7491	-0.8849	0.0429	0.9293	1.6153	0.5219	-0.292	0.776	0.1201	-0.0919	0.3726	0.0007	0.3146	-24.1039	-44.2991	94.8785
22	8.3381	7.0315	-0.8038	9.2423	-3.0093	4.0237	-0.8577	0.6663	-0.6914	-2.6061	0.6986	-1.1817	0.1473	0.3969	0.1153	0.6909	0.1281	0.0443	0.5173	-0.0089	0.2962	-21.4657	-34.2623	83.7158
23	3.2554	2.8802	0.3743	7.5062	-0.7779	3.0622	-0.2535	0.1076	-0.4324	-1.0368	0.3179	0.0454	0.4503	-0.2804	-0.005	0.5846	0.0417	0.0034	0.4342	-0.022	0.3631	-28.6812	-38.0292	86.7369
24	3.6857	3.8578	-0.8995	8.9599	-1.0816	4.051	-0.0714	0.3699	-0.2585	-0.9446	0.0141	0.0923	1.0116	0.2811	0.1545	0.7758	0.1196	0.0326	0.4503	-0.0494	0.3472	-22.9784	-42.5425	85.7188
25	3.8585	-0.3908	1.0051	4.2707	-2.8514	4.6981	0.3437	-0.6787	-0.5501	-0.6937	-0.8234	-0.3311	1.9644	1.7673	0.4315	1.0293	0.3411	0.0471	0.548	0.0151	0.3562	-21.2262	-46.681	96.8389
26	9.1998	-4.7627	3.9519	8.3816	-5.6816	6.5552	0.058	-0.1429	-0.8168	-1.0069	-0.0314	0.9222	0.8072	0.1727	-0.2149	0.8365	-0.0879	-0.0237	0.3463	-0.0318	0.5101	-35.9362	-47.0613	85.8573
27	9.5314	4.0801	-3.2682	2.8461	-2.3659	2.2664	-0.8709	1.4304	-0.4279	-0.4154	0.5675	0.0182	-0.6104	-0.3226	0.3169	0.9145	-0.0189	-0.2518	0.5706	-0.0954	0.5988	-43.8435	-38.8957	77.2208
28	8.9516	6.7901	-4.5204	8.2413	-1.1858	6.6165	-0.8737	0.073	-3.4607	0.2968	-0.4861	-0.8691	0.1902	-0.9761	1.1985	1.3884	-0.0375	-0.0022	0.7026	-0.0598	1.4741	-47.6437	-56.5302	85.8662
29	6.4313	5.5071	-0.1203	7.1822	1.8865	1.0079	0.0367	-0.4813	-0.4034	-0.8293	-0.5021	0.2547	1.3454	0.3719	0.4385	0.7797	-0.0517	-0.07	0.3966	0.0664	0.3921	-38.106	-41.3291	89.4207
30	4.434	-3.8961	-6.4042	8.8776	5.6169	9.5313	0.0897	0.8532	0.2498	-0.9167	-0.337	0.052	-0.6468	-0.6711	0.2097	0.723	-0.0904	-0.1643	0.4956	0.0509	0.3849	-34.7012	-24.0938	78.6778
31	7.3455	7.1617	-6.2734	6.4608	-6.5604	6.5357	-1.0023	2.0847	1.1468	-1.2933	1.7337	2.1538	1.7335	-1.5041	-0.7755	0.7328	-0.2656	-0.1593	0.6138	0.1577	0.5646	-47.6593	-34.4617	85.8377
32	4.2256	6.4159	-3.4724	9.6923	-4.8913	9.6122	-0.0206	-0.4226	0.451	-0.1856	0.1354	1.0659	0.4002	-0.7817	-0.178	0.5579	-0.0159	-0.0053	0.4788	0.0995	0.5174	-52.017	-35.8164	91.0392
33	4.3909	3.2318	-3.319	5.6266	-5.4375	5.5687	0.0759	0.0363	-0.0971	0.7918	-0.1527	-0.2134	-0.1364	0.0979	0.0507	0.4931	-0.02	-0.0532	0.2848	-0.0303	0.2855	-33.679	-28.3067	89.5043
34	5.4436	7.3311	5.768	9.9659	7.9355	6.3039	0.2231	-1.238	-1.3143	0.825	0.376	0.2616	1.9767	0.1128	-0.4108	0.6952	-0.0616	-0.178	0.6633	0.2014	0.6704	-46.0221	-44.3538	91.7017
35	4.301	1.0806	1.044	2.3805	-2.2274	3.1114	-0.29	0.1784	0.4227	-1.1274	0.4727	0.8777	0.3964	-0.79	-0.2031	0.6734	-0.2128	-0.1555	0.5508	0.046	0.5139	-44.2753	-32.6206	80.6874
36	7.843	1.2383	-0.2374	1.2974	-2.5274	5.2366	0.206	-0.6093	-0.5067	-0.6979	-0.908	-0.0385	1.0264	0.1672	0.5263	0.8783	-0.0417	-0.0628	0.3205	-0.0067	0.3904	-37.1718	-44.9779	87.5188
37	4.9857	0.6649	-3.3929	1.3792	-1.4131	3.236	-0.217	-0.1144	-0.2903	-0.1804	0.8442	1.5497	0.7967	-0.5739	-0.5068	0.5773	-0.1226	-0.1555	0.7158	0.1343	0.4423	-51.7973	-37.964	96.8289
38	2.976	3.2924	-3.0898	5.4717	-6.4856	8.2322	0.0376	-0.2822	0.0789	0.0691	-0.177	1.108	-0.3889	-0.267	0.1715	0.4671	-0.0119	-0.0259	0.7731	-0.0928	1.0353	-56.8219	-25.2106	100.3688
39	5.1555	0.0791	0.4056	6.3859	-1.2774	3.9443	0.4218	-0.4531	-1.1184	0.6428	0.0106	1.299	0.4243	-0.3889	-0.4089	0.5359	-0.0984	-0.0175	0.6142	0.1465	0.7557	-53.0593	-38.5594	103.4947
40	8.8295	3.1926	-1.5	4.769	-5.347	8.8846	0.5844	-0.371	0.9439	0.2126	0.1717	1.6764	-0.1552	0.0237	-0.9303	0.4374	0.0655	0.0607	0.3892	0.029	0.5034	-47.2	-20.1923	100.2327
41	3.5934	0.8725	-2.3802	8.1416	-1.4447	3.362	0.1905	-0.5857	-0.018	0.5827	-0.0554	0.6901	-0.0343	0.3182	-0.0856	0.269	-0.0633	-0.0626	0.3709	0.0327	0.4219	-43.2735	-25.66	105.3842
42	2.0248	4.5839	-1.6945	8.4907	-4.1491	2.1064	0.5214	-1.9842	-1.9409	-0.1638	-0.7402	0.5105	-0.2379	1.4298	-0.0968	0.4334	0.0206	-0.0744	0.5775	0.1269	0.4117	-49.2577	-36.0918	108.3767
43	8.0138	7.8583	-4.8359	9.5596	-2.5607	7.4075	0.1553	-0.3519	0.7795	0.3696	-0.0438	0.4766	-0.5712	-0.3028	-0.0648	0.3521	0.0941	0.0142	0.4243	0.0366	0.5627	-51.1384	-21.3429	101.7055
44	8.5981	4.938	-5.0249	4.6992	-6.112	9.595	-0.5228	-0.3385	-0.114	-1.3382	0.2444	1.0175	1.3121	0.3934	-0.0221	0.5715	-0.086	-0.0133	0.4959	0.1338	0.4839	-50.4312	-37.9483	99.0243
45	7.6396	-2.3569	3.5625	2.8795	-1.8179	3.0562	0.0869	-0.8797	-0.7492	-0.0962	-0.1263	0.2247	0.8835	-0.1661	0.172	0.4752	-0.052	-0.0023	0.4256	-0.0516	0.475	2.2	-52.4985	39.8322
46	4.6876	1.226	-6.3966	3.1124	0.4466	2.0163	-0.777	1.0132	-0.7202	-2.18	0.5792	-1.1071	1.2417	-0.7514	0.4039	0.6124	0.0356	-0.004	0.7098	-0.2076	0.5289	-0.1199	-46.924	25.4311
47	6.1456	1.2329	0.8871	7.9878	-2.4979	8.0775	-0.3163	-0.224	-1.6273	-0.581	0.3156	-0.0071	1.5647	-0.278	-0.0735	0.4887	0.0171	0.0777	0.3648	-0.0312	0.6744	-3.6245	-53.8039	37.7731
48	6.4771	1.9356	-5.3984	3.5206	-4.1688	5.5357	-0.3756	0.8464	0.1839	-0.5527	0.4449	0.2547	0.2117	-0.0151	-0.2072	0.3345	-0.0018	-0.0454	0.4521	-0.0257	0.2959	-2.2995	-36.5125	28.7392
49	3.4619	3.2874	-1.9196	7.6684	-1.2162	5.3884	0.0951	0.1143	0.0399	-0.2047	-0.1769	1.1461	0.3641	-0.9616	-0.0725	0.2168	-0.0357	-0.0623	0.502	-0.0715	0.5038	-14.5379	-43.5414	32.6091
50	4.0839	3.6635	-3.3711	4.0857	-5.2314	6.8699	-0.1792	0.2652	-0.0436	0.6025	0.2185	-0.2784	-0.4422	0.0191	-0.0023	0.2324	-0.0143	-0.0096	0.2552	-0.0262	0.357	0.7928	-32.3824	38.1014
51	7.4349	3.3475	0.9953	4.6968	5.871	9.2406	0.2377	-0.5509	0.0162	0.064	-0.275	-0.0902	0.5757	-0.458	-0.014	0.252	-0.009	-0.0534	0.3456	0.0195	0.4867	-8.9947	-50.3766	38.0167
52	6.5886	3.5861	-1.1563	3.2675	-3.3144	7.4212	-0.4786	0.6978	0.1054	-0.7988	0.4133	0.3195	-0.0556	-0.8026	0.0363	0.3622	0.0016	0.0143	0.5441	-0.0969	0.2977	-3.1589	-40.261	26.6859
53	4.3185	-0.1238	0.0185	2.6257	-2.7934	6.7461	0.1283	-0.1929	-1.138	0.1443	0.2522	-0.2538	0.2598	-0.171	-0.3457	0.2544	0.0275	-0.0512	0.3833	0.0398	0.5712	-0.0312	-50.8194	39.5482
54	3.6496	-0.8888	1.3698	8.0128	-2.1539	5.1384	0.3333	-0.1556	0.0641	-0.5953	-0.2501	0.4875	0.5723	-0.0415	-0.3662	0.2181	-0.0527	-0.0588	0.5139	-0.0323	0.391	-17.2789	-44.5732	38.0487
55	2.8327	3.1212	-3.8195	4.678	-6.592	2.1354	-0.482	1.2632	0.5861	-0.3469	0.3249	-0.0095	0.1221	-0.7512	0.2528	0.4337	-0.0716	-0.1225	0.5298	0.091	0.536	-24.6846	-32.8553	35.2309
56	7.2202	-3.987	4.4902	3.8689	-3.9724	4.1676	-0.7991	0.3137	-1.8043	-0.841	1.2755	2.0811	1.3186	-1.9884	-0.5209	1.148	-0.3101	0.0711	1.2317	-0.1313	1.317	-29.4485	-49.7576	44.3662
57	4.5876	0.797	-1.833	7.9913	-3.6325	6.1979	-0.0122	-0.2277	-0.488	0.4438	-0.1015	0.2782	0.1229	0.2813	0.1416	0.2898	-0.0167	-0.0034	0.3088	-0.0461	0.3667	-15.0504	-39.3034	42.4405
58	5.9224	0.3202	-2.2031	8.8735	-1.8378	6.8368	0.3278	0.6564	0.4748	0.0781	0.1555	0.4993	-0.5981	-1.2152	-0.5668	0.2	-0.0197	-0.1511	0.4695	0.0681	0.3652	-16.9648	-25.8967	39.0455
59	4.1784	4.9645	-4.6813	5.9392	-5.5813	5.274	-0.8524	-0.9463	-0.3882	1.0443	-0.5446	1.0101	0.6553	-0.0342	1.3774	0.672	-0.1614	0.2318	0.8562	0.0732	0.7392	-28.9962	-34.8643	58.2475
60	5.5876	7.1535	-7.8816	8.4716	-7.6066	8.1641	0.5555	0.0961	0.1683	0.512	-0.2001	0.2379	-0.4149	-0.4017	-0.3404	0.2836	-0.0288	-0.0557	0.4534	0.0526	0.293	-13.5143	-26.1885	42.9508
61	4.9369	5.4234	-5.6939	7.215	-4.3857	7.5216	0.1859	-0.5212	-0.6618	0.1524	-0.3266	-0.2574	0.2892	0.2741	0.1664	0.3026	-0.0439	-0.0667	0.3257	0.0425	0.3333	-15.8624	-38.0775	46.6443
62	7.5527	5.2056	-1.7263	4.1483	-2.6805	4.9373	0.1742	-0.4905	0.6403	-0.0912	-0.4227	1.4282	-0.3375	0.2001	0.1561	0.2742	-0.0098	0.0384	0.4768	0.0454	0.4725	-21.1111	-27.5107	38.5674
63	3.3971	3.3626	-2.3828	3.7563	-5.0261	8.7843	-0.5458	-0.0549	-0.2797	-0.6211	0.3533	-0.1925	0.7421	-0.3807	0.2917	0.2783	-0.0251	-0.0123	0.3213	0.0374	0.4744	-17.1538	-43.8179	40.8948
64	5.951	1.2207	0.1081	7.1269	2.6872	4.4724	0.397	-0.5629	-0.4286	0.5588	-0.5515	0.5151	0.2886	-0.3513	0.096	0.2955	-0.0761	0.0403	0.5087	0.0159	0.3938	-20.6944	-35.9418	56.4442
65	4.1623	6.0503	-4.0179	9.0669	-5.6845	3.7213	0.4026	0.0695	0.7151	-0.5905	-0.452	0.0336	-0.3234	-1.0785	-0.0329	0.4889	0.049	0.1654	0.5379	-0.0331	0.708	-18.7677	-21.2419	61.8155
66	3.5498	-4.206	-3.9687	5.5529	6.1559	9.2878	-0.8542	0.0634	-0.1521	3.1685	0.3087	0.6709	2.1916	-1.5168	0.4087	1.1882	-0.1246	0.1944	1.5823	0.263	0.9654	-23.5628	-38.9513	69.5923
67	7.0325	6.0075	-1.7303	6.7909	-1.4786	3.8348	0.4158	-0.086	0.2267	0.5786	-0.3492	0.1033	-0.2727	0.0781	-0.1057	0.2309	-0.0231	-0.0085	0.4341	0.04	0.3374	-12.0843	-25.2428	53.2765
68	9.8145	4.1263	-4.5179	4.3106	0.2486	3.6772	0.3435	-1.448	-0.1443	1.974	-0.7266	-0.1103	-1.733	0.5108	0.1521	0.4882	-0.0255	0.0563	0.4857	-0.0122	0.3461	-8.8917	-24.2701	63.5416
69	2.0015	-5.6417	2.2824	4.6217	-2.8041	2.0229	0.3714	-0.6485	1.2089	0.8927	0.919	-0.468	1.1089	0.7674	-0.5876	0.9802	0.0434	0.0892	0.6127	0.1394	0.6083	-5.1294	-34.4145	75.7732
70	2.6441	1.7517	-2.809	9.0466	-7.2319	5.2245	-0.212	-0.3969	0.1769	0.1494	-0.1401	-0.456	-0.1099	0.3396	0.4462	0.2755	0.0082	-0.0001	0.3273	-0.0256	0.2693	-5.0446	-22.8705	55.5399
71	2.3875	2.0647	-6.8633	6.1016	-2.2022	4.9018	-0.4608	0.3177	-0.5704	0.1167	0.2895	0.0159	1.0081	-0.7255	0.3143	0.2768	-0.0867	-0.0236	0.4755	0.1219	0.4103	-10.4264	-33.8231	58.7662
72	4.6291	3.0793	-0.6857	3.0275	-0.3471	6.1835	0.278	-0.4406	0.0916	0.5977	-0.1245	0.3476	0.0654	-0.1595	-0.1792	0.2837	-0.006	0.0904	0.3376	0.0267	0.3406	-15.1788	-27.4653	58.6745
73	4.5064	2.3859	-2.3725	5.27	-4.4407	3.8621	-0.0896	-0.6236	-1.1596	0.3795	-0.0016	-0.5426	-0.1616	-0.3282	-0.0261	0.516	-0.0452	-0.0114	0.4429	0.0555	0.409	-3.4865	-36.3307	67.4505
74	3.7039	-1.071	-1.0769	5.8203	-2.1794	5.2101	0.2473	-1.0718	-0.3685	0.9827	-0.1648	0.3475	0.1196	0.0173	0.1209	0.7241	-0.086	-0.1516	0.8014	0.0902	0.407	6.6338	-34.7491	73.1379
75	6.6102	3.5848	-1.2782	7.9294	-1.7696	7.1415	-0.1194	-0.2865	-1.0016	-0.4296	-0.2537	-0.2205	1.1221	-0.0287	0.4334	0.2752	-0.0305	0.0241	0.3066	0.0432	0.3364	0.5276	-36.5496	62.4246
76	5.615	-1.2853	0.1358	8.6884	-0.5041	4.4796	0.1897	-0.1463	0.4273	0.4885	-0.3258	-0.9581	-0.053	0.2405	0.2073	0.3929	-0.1009	-0.0475	0.3909	-0.0131	0.2585	10.6788	-26.0672	57.8287
77	3.279	0.2547	1.6244	2.285	-3.7106	5.8483	0.3245	-0.0266	-1.0673	0.4839	-0.535	-1.031	0.5157	0.8052	0.082	0.4741	0.0136	-0.2379	0.4008	0.0754	0.8018	14.1814	-40.3684	59.0052
78	6.2338	5.1333	-3.9131	5.9674	-7.5574	9.3834	-0.3966	0.221	0.4036	-0.57	0.7189	0.4581	0.2833	-0.2497	-0.2047	0.2716	-0.0379	-0.0741	0.3119	0.0259	0.2933	2.4939	-26.3838	50.8128
79	3.499	-3.7854	3.1185	4.0801	-3.4419	7.4742	0.9502	-0.3382	-0.2808	0.4197	-0.6459	-0.0044	0.4799	-0.3744	-0.7795	0.3915	-0.0636	-0.0695	0.4909	0.0384	0.4364	5.2709	-42.0681	63.4953
80	5.1925	1.6552	-1.9333	7.1179	-3.2562	4.1799	0.0282	-0.062	-0.2274	0.4267	0.0738	-0.0792	-0.1926	0.1647	-0.1126	0.44	-0.1212	-0.0786	0.4328	-0.0081	0.2441	4.996	-32.0427	63.8859
81	8.1544	0.2392	-5.1785	5.8432	-2.393	4.1043	-0.5231	0.3021	-1.1704	0.2337	0.1647	-0.5576	0.8753	-0.1766	0.5318	0.4928	-0.1328	-0.1653	0.5056	0.1047	0.5677	11.6154	-45.3416	56.5427
82	6.6196	5.2179	-1.6593	6.0229	-5.5074	9.2664	0.2074	0.1041	-0.6718	0.4579	0.2633	-0.4333	-0.2231	0.1627	-0.2983	0.3316	0.0844	-0.069	0.65	-0.022	0.5993	20.9404	-43.7315	45.9028
83	0.3094	-0.8237	0.2643	3.5841	-3.8916	7.3411	-1.2557	-0.4564	-2.2172	-0.8772	-0.5572	-1.4173	1.8692	0.4934	1.5543	1.0851	0.2172	-0.1172	0.8738	0.18	1.4805	14.853	-59.7641	55.2049
84	6.9821	0.5517	-1.788	7.9483	-4.0244	5.7048	-0.2816	-0.1552	-0.6394	0.1877	0.5379	0.1439	0.7729	-0.3368	-0.3017	0.4271	-0.042	-0.07	0.3476	0.0319	0.2823	7.7477	-45.1214	51.2205
85	4.1726	5.7021	-0.8661	7.8814	-2.6177	3.1258	0.1897	-0.0865	-0.7374	-0.5235	-0.0847	-1.6161	-0.1408	0.1562	-0.0823	0.188	0.0334	0.0081	0.4129	0.0536	0.4889	14.68	-36.6121	40.3936
86	8.4417	5.7777	-5.1372	4.179	-4.7669	1.9799	-1.0108	0.7781	-1.0621	-0.5786	-1.1487	1.4041	2.1465	-0.0826	0.9156	0.5639	0.0205	-0.0479	0.5958	-0.134	1.4305	5.8574	-59.3153	36.3423
87	1.3261	0.2707	-0.353	8.7611	0.3344	1.0915	-0.0173	-0.042	-0.1805	0.1294	0.2213	0.124	0.1164	0.1981	-0.1718	0.2638	-0.0067	-0.0605	0.3043	0.0306	0.3584	7.899	-36.493	41.6827
88	5.0252	-2.0704	-0.1678	6.8215	-0.8978	4.5372	0.1282	0.3824	-0.3854	-0.1078	-0.2995	-0.174	0.274	0.4215	0.0707	0.1892	-0.0201	-0.0289	0.3589	-0.0048	0.4198	13.3623	-44.4953	43.4102
89	9.2764	1.8627	-1.7917	4.0412	-3.7821	4.1736	0.0559	-0.6153	-0.3059	-0.1684	-0.4394	0.4322	0.5128	0.4199	0.4859	0.3868	-0.0559	-0.0472	0.3818	0.0039	0.3186	8.9333	-48.0568	55.7594
90	8.4231	5.091	1.0823	3.5974	1.609	4.7202	0.4803	-0.0974	1.1193	1.0648	-0.2982	1.3433	-0.6587	-0.1977	-0.0938	0.4299	0.1381	0.1323	0.424	0.0256	0.5505	-34.6013	18.7224	88.1521
91	5.6653	4.4457	-1.6306	4.122	0.0488	3.8567	-0.034	-0.2226	0.8121	0.7681	0.889	0.3325	-0.816	-1.6983	-0.9363	0.4697	0.0414	0.0775	0.6312	-0.0186	0.7956	-46.579	11.251	87.0152
92	5.6909	5.7734	-6.3852	5.8615	-6.3733	6.9844	2.0159	1.2448	1.7502	1.7058	-0.4072	1.2128	-3.8954	-0.1302	-1.7427	1.537	-0.0011	0.2943	0.8268	0.0029	1.0946	-40.2869	28.9826	78.635
93	3.0778	0.121	0.5009	5.4572	-3.1304	4.7498	0.2831	-0.2022	-0.065	0.3467	0.1025	0.5898	-0.3836	0.1529	-0.3892	0.3605	0.0033	0.0978	0.3705	-0.0906	0.3996	-36.37	6.1123	87.5462
94	5.6006	3.2413	-2.4201	3.3041	0.3239	3.1004	0.1664	-0.0672	0.378	-0.7517	1.1428	1.1141	0.0749	-1.621	-1.7024	0.3529	0.0238	0.0112	0.3938	0.0673	0.5471	-42.2883	6.6633	78.6936
95	2.1519	2.4263	-2.1313	3.8496	-1.2489	3.5227	0.221	2.7586	0.8292	-0.9118	-1.0411	0.3603	-0.6578	0.3321	0.3699	0.4539	0.0139	-0.048	0.7516	0.3014	0.7927	-41.3896	14.4239	64.2585
96	4.5662	-4.091	4.298	5.1103	-5.9138	2.9803	0.2051	0.376	0.4626	-0.1367	-0.3883	-0.0279	0.0759	0.3075	0.06	0.3809	0.0066	0.0279	0.4027	0.0556	0.4268	-37.1833	0.3945	82.5111
97	3.9999	-6.2367	4.1382	9.8474	-7.5757	7.1261	0.0194	0.0879	0.9523	0.0181	-0.0426	-0.5771	-0.2972	-0.0054	0.1923	0.4261	-0.059	0.0889	0.3195	0.0353	0.4571	-33.025	11.9885	79.763
98	8.8294	2.7401	0.2536	9.2134	-4.8518	6.8008	0.56	0.0488	-0.4949	0.2668	0.2267	1.7046	0.1191	-0.3222	-0.9184	0.3037	0.0146	0.0939	0.429	-0.018	0.6792	-44.576	4.9698	84.3988
99	4.3047	3.9382	-2.3119	4.4236	-3.8573	3.8559	0.3737	0.0337	0.8648	1.0977	-0.2842	0.7801	-0.95	0.2312	0.0034	0.5121	-0.0779	0.0531	0.4794	0.0376	0.5425	-33.5516	17.8264	85.489
100	8.8147	0.6443	-6.1973	4.5706	1.9498	8.7532	0.1867	-1.5474	1.2458	-0.5089	-0.3447	-0.0642	-0.3533	1.5118	-0.2311	0.5948	-0.2443	-0.0653	0.6502	-0.1101	0.4225	-14.6695	16.5134	95.1099
101	6.6948	2.3383	0.0732	4.5128	-4.6528	5.9426	0.4219	-1.0207	0.3741	1.674	-0.8675	0.2341	-0.527	-0.6866	0.408	1.0609	-0.1286	-0.0376	0.7597	-0.1728	0.4618	-23.728	13.7016	105.7239
102	4.5496	1.5704	-6.3207	0.5133	-2.1565	8.5985	2.3786	-0.4119	1.4756	1.1612	0.1743	-0.3234	-2.7148	0.3898	-1.842	1.452	-0.2402	0.0626	0.8658	-0.257	1.3085	-18.605	30.737	96.6845
103	1.8124	1.1022	-1.9457	8.6293	-5.0078	5.9129	0.1768	0.0921	0.2861	-0.0959	-0.337	0.2044	-0.2004	0.4914	0.1156	0.3733	-0.1173	-0.0226	0.5502	-0.0355	0.3269	-20.4775	13.1494	92.3618
104	2.8682	3.3535	-0.1155	9.0737	-5.95	5.659	-0.2743	-0.6919	-0.1644	1.1373	0.3591	1.0991	-0.4879	-0.3212	-0.184	0.5047	-0.0496	0.0711	0.5812	-0.0954	0.2975	-28.5447	5.2664	100.5856
105	2.1979	-4.2421	1.4433	2.0155	-6.9287	9.0565	0.0661	0.7036	1.3791	0.653	0.4947	1.1739	-1.7341	-2.3043	-0.4041	1.1888	0.3747	0.2444	0.7242	0.1888	0.8534	-37.6195	25.9274	91.2237
106	4.1887	-3.918	1.2971	3.5783	-2.5244	3.4794	0.0463	-0.4543	0.4375	0.1848	0.1138	-0.3544	-0.3991	-0.3195	-0.1524	0.4393	-0.0411	0.0804	0.373	-0.0409	0.3273	-29.666	4.2458	95.4174
107	5.6243	-1.5029	-2.2129	2.4769	1.1498	8.8335	0.2835	-0.2266	0.494	-1.074	-0.0412	0.5422	-1.0274	0.4945	-0.0251	0.3482	-0.1121	0.0388	0.449	-0.0568	0.3198	-24.1754	14.3769	90.3293
108	3.9759	1.4756	0.1992	6.5676	-0.9626	2.4221	-0.0766	-0.2848	0.3292	0.4541	0.0423	0.213	-0.2535	-0.2256	0.0674	0.5314	-0.0416	0.0205	0.4214	-0.1037	0.3344	-22.9715	12.1395	98.4981
109	6.1314	0.8073	-0.4382	6.3976	-5.7585	5.1158	-0.2239	-0.5314	0.3211	0.9061	-0.2134	-0.3737	-1.2568	1.1893	0.4921	0.4845	-0.1407	-0.041	0.7814	-0.1775	0.3684	-3.5161	6.8341	80.0505
110	7.8335	5.6998	-2.2141	4.5252	-0.5204	3.6102	0.255	-0.9194	-0.587	1.2206	-0.4518	-0.5309	0.0199	0.9914	0.3408	0.5943	-0.039	-0.1007	1.1812	0.2262	0.499	0.0782	1.4429	93.1688
111	3.5676	-1.9725	3.9335	4.5532	-0.7842	4.8728	-0.2213	-0.4394	0.3274	-1.2179	-0.1714	0.0075	-0.0143	0.7698	0.7684	1.3332	-0.5625	0.5009	2.0158	-0.3899	1.3913	4.4631	18.0658	83.8536
112	3.9844	2.0542	-1.9064	2.8295	-2.5608	6.9395	0.4405	-0.1484	-0.0408	0.7722	-0.4574	-0.3077	-0.5658	0.6977	0.0193	0.3415	-0.0636	-0.0086	0.4998	-0.0397	0.2587	-9.6879	0.7647	87.5767
113	3.6128	2.5062	-3.384	3.0249	-4.7634	7.5127	0.6438	-0.5695	0.6373	1.8535	-0.5754	-0.9518	-0.3765	1.4702	-0.013	0.3994	-0.1418	-0.0897	0.8004	-0.0285	0.4962	-8.7021	5.6239	96.3
114	7.2995	3.2008	1.0616	2.7027	-1.5748	4.7761	-0.1196	-0.1397	1.173	0.9591	0.0356	0.5833	-0.9836	0.5536	-0.0106	0.6751	-0.1263	-0.0494	0.607	-0.0125	0.4431	-11.2968	12.0118	97.5788
115	6.1109	4.4523	-4.292	4.076	-2.1297	4.0553	0.2186	0.7744	0.3463	0.0851	0.4682	0.153	0.4092	0.2331	-0.6039	0.4439	-0.023	-0.076	0.4605	0.0229	0.3341	-18.549	-9.0967	90.2767
116	9.1088	6.9669	1.6478	4.9907	-0.1661	6.3761	-0.2337	0.6149	0.5545	-0.1065	0.1201	0.4963	-0.7164	0.6155	-0.0082	0.2767	-0.056	0.053	0.6758	-0.017	0.3159	-11.6103	9.4306	86.6812
117	0.4125	0.3212	-0.6344	5.7084	-3.1761	7.1437	0.2335	-0.1349	-0.0463	0.3297	-0.2284	-0.1677	-0.4268	0.9401	0.075	0.1962	-0.1071	0.0023	0.6115	-0.0632	0.3787	-5.8189	4.292	88.4166
118	6.2882	-3.5374	0.2385	3.008	-2.9196	6.7466	-0.2101	0.6751	0.5344	-0.4288	-0.1202	-0.5108	-0.2867	0.6302	0.1263	0.4166	-0.1504	-0.0757	0.6642	-0.0109	0.3304	-16.4485	4.7121	63.7817
119	5.6323	4.6705	-3.7954	5.741	-6.7949	9.83	0.0238	0.8958	-1.0421	-1.7057	-0.1367	-1.1647	0.825	0.5526	0.173	0.5495	-0.0066	0.0257	0.7477	-0.2531	0.5573	-7.3088	-8.4387	66.4375
120	8.2857	0.9866	3.4037	4.8973	2.7553	2.5572	-0.1577	0.1354	2.9287	1.0062	-1.6165	0.5715	0.7628	0.1001	1.5021	1.1059	-0.2201	0.0069	1.7208	-0.1847	1.3646	-4.3117	9.2719	58.2013
121	1.9388	1.1759	-0.3221	8.7256	-6.2379	6.6066	0.0815	0.1649	-0.3232	-0.4659	-0.3729	-0.3514	0.3553	0.7022	0.2715	0.3112	0.0179	-0.0175	0.5083	-0.0582	0.2913	-15.8721	-4.3412	72.6448
122	4.0994	3.0628	-4.7166	3.6064	-4.3077	5.4791	0.4165	0.1536	-0.6408	0.3889	-0.1273	-1.3471	-0.214	1.0049	-0.068	0.4092	-0.0276	-0.0124	0.7327	-0.0387	0.4349	-6.052	-4.3665	75.3729
123	4.7231	1.2311	0.1939	5.6343	-1.4758	3.6279	-0.0371	-0.2557	-0.1167	0.0442	0.0138	-0.4822	-0.3479	1.0007	-0.0598	0.3088	-0.0727	0.0119	0.5858	-0.0825	0.2351	-10.682	-2.4034	78.9277
124	7.1131	-3.0399	-6.8355	6.6672	5.0937	7.4049	1.0017	0.1376	0.2917	-1.2994	-0.7251	-0.112	-0.997	0.3643	-0.1235	0.3157	-0.0956	0.0602	0.6818	0.0243	0.3669	-7.8511	6.3885	70.9426
125	4.7585	0.0744	1.1779	3.0865	-3.9944	5.9633	-0.1471	0.4307	-0.104	-0.3676	0.0551	-0.3567	0.1451	0.7628	0.0826	0.3902	-0.0298	0.0587	0.4978	-0.0947	0.2297	-12.072	-2.699	69.4944
126	5.5127	-3.3426	1.8502	4.233	0.4764	6.0785	-0.1593	0.1132	0.5724	-0.5346	0.4951	0.5053	-0.4436	0.1874	-0.1978	0.3291	-0.051	-0.0279	0.4631	0.0151	0.2991	-34.4433	11.666	68.4888
127	4.9786	-0.6135	1.0831	7.8461	-1.3634	3.9681	-0.1187	0.5201	0.3986	-1.1611	-0.016	0.0767	-0.0492	-0.1532	0.0924	0.3984	-0.0317	-0.0485	0.4246	-0.0236	0.3641	-33.5374	6.0942	63.1768
128	5.5471	3.0701	-0.8109	7.726	-2.8468	4.656	-0.4331	0.3358	-0.027	-0.9322	0.3905	0.3848	0.851	-0.2003	0.1377	0.3872	-0.0968	-0.0945	0.3369	-0.0149	0.2507	-31.3295	-8.0377	69.8873
129	2.7759	1.675	-0.9316	4.303	-1.7533	3.0638	-0.1945	0.411	0.0775	-0.4882	0.197	-0	0.146	0.3372	0.0429	0.3088	-0.0524	-0.0782	0.5071	0.0236	0.2818	-24.5817	-2.8228	70.0909
130	5.7763	2.1939	-1.2066	9.8063	-4.7553	7.3374	0.0777	0.2565	0.0743	-0.8447	0.05	0.1821	0.3485	0.2476	-0.1371	0.2703	-0.0387	-0.0624	0.3625	-0.0031	0.2488	-29.6443	-1.2852	65.0918
131	6.8484	1.5281	-1.6393	3.1977	-5.5071	9.4682	0.1685	-0.1987	0.5705	-0.4116	-0.045	0.7901	-0.2869	0.1657	-0.0963	0.343	-0.0602	-0.0411	0.3556	0.0076	0.4134	-32.9762	9.8947	68.5893
132	5.2145	5.4946	-2.8002	9.3006	0.5686	3.5957	0.5192	-0.4854	1.1172	0.3391	-0.4017	0.6142	-0.5187	0.2409	-0.0779	0.3241	0.0174	0.009	0.3712	0.0522	0.3944	9.5692	15.636	41.6157
133	7.0187	3.9474	1.4945	4.5673	-3.2975	7.788	-0.233	-1.1173	1.5081	0.2278	0.3772	-0.5663	-0.6497	-0.4761	-0.33	0.5353	-0.0317	0.3016	0.3881	-0.0471	0.7578	-2.9756	12.6606	47.3226
134	5.6909	2.5944	-1.6404	5.3462	-0.6201	5.2712	-0.6965	0.4541	2.164	1.6465	0.1179	-0.2528	-1.2752	-0.6624	0.6013	1.114	0.2038	0.0697	0.7202	-0.0217	1.586	3.2401	28.9734	39.0402
135	9.0402	5.7061	-2.7884	8.2305	-2.7124	6.9975	-0.1535	0.4516	0.6345	-0.5958	-0.3305	-0.3642	-0.295	0.4099	0.262	0.2485	-0.0431	-0.0181	0.3787	0.0239	0.2712	6.3002	12.4291	36.7839
136	5.3011	4.0988	-0.8097	7.4408	-5.0771	9.0746	0.1011	-0.2972	-0.4075	0.7669	0.7619	1.3078	-0.7993	-1.047	-0.9682	0.3402	0.0684	0.1329	0.3965	-0.0582	0.3187	-3.995	2.7442	42.6094
137	4.5253	0.7224	-0.7991	7.5855	-4.8503	6.3103	0.5871	1.0412	0.6381	-0.388	-0.1448	0.7247	-0.6744	-0.4376	-0.3941	0.453	0.1227	0.0574	0.5486	0.1235	0.3842	-7.2977	11.6794	31.5835
138	4.6789	5.0815	-4.0691	9.7342	-4.1019	3.3591	-0.5818	0.4498	-0.201	-0.5268	0.5809	-0.4586	0.252	-0.5261	0.0216	0.2747	-0.0148	-0.0075	0.362	0.016	0.3336	4.3311	-2.7117	38.4915
139	8.7696	-6.3774	-4.3466	4.9459	4.2729	7.9768	0.7655	0.5553	0.928	0.2165	-0.1899	0.3539	-0.6755	0.4042	-0.5757	0.4233	0.0269	0.0503	0.4658	0.179	0.4886	1.5928	16.9123	32.9307
140	7.7877	3.5547	-1.6594	7.3628	-4.5401	6.2776	-0.0429	0.091	0.2235	0.4906	0.1578	0.9767	-0.1693	-1.1062	-0.1843	0.3726	0.0463	0.1747	0.3793	-0.0225	0.3803	-5.2463	6.7574	43.6852
141	9.1606	4.8974	-4.815	2.6474	-2.9202	2.8675	-0.0291	0.3386	0.5229	0.2627	0.0305	-0.2784	-0.409	-0.0145	0.1531	0.4456	-0.1068	0.0485	0.2999	0.0063	0.4533	8.5916	15.261	38.8954
142	6.5975	5.2751	3.4616	4.8793	1.1838	7.4386	-0.1873	0.378	1.1088	0.1502	0.5298	1.976	-0.7441	0.0824	-0.0577	0.3135	0.117	0.1134	0.3645	0.1378	0.5441	-4.7077	12.794	26.2638
143	5.5759	5.0861	-2.7211	6.2176	-0.8412	3.8049	-0.056	0.7758	0.4213	0.5639	1.2208	0.59	-0.8903	-1.5989	-1.1762	0.3776	0.0958	-0.0347	0.5977	0.096	0.5727	-13.809	3.2358	21.3896
144	2.0154	7.5761	5.5495	6.3846	5.4723	5.4933	-2.0103	0.9203	3.0936	-1.2375	-0.1736	2.3393	-2.3902	0.5312	1.8803	1.6484	0.2783	-0.2783	1.0968	0.1753	1.2598	-8.0123	20.1993	13.4608
145	7.4918	1.7935	1.2128	8.5482	0.5521	0.518	-0.0349	-0.1077	0.4605	-0.6918	-0.3153	-0.3406	-0.3211	0.7988	0.4183	0.4013	0.0073	0.0941	0.4129	0.0171	0.3572	-0.9161	8.1932	23.3012
146	5.6494	2.8655	-3.0874	9.3044	-2.4834	2.2076	0.1469	0.3075	0.0674	-0.2757	0.1427	0.2647	0.6306	-0.6561	-0.6068	0.1618	-0.0016	-0.0899	0.5048	0.0321	0.3904	-7.5367	-5.5164	24.0397
147	3.1591	2.131	-1.6105	2.2748	0.1404	2.2129	0.144	0.5469	0.0881	-0.7411	0.0773	0.0816	0.6671	0.446	-0.1036	0.3132	0.0017	0.0107	0.4968	0.0882	0.429	-1.0054	-0.7339	11.8767
148	3.807	3.2569	-1.8279	3.528	-3.0484	3.9587	0.1448	-0.3226	-0.1959	0.0511	0.0011	-0.5396	0.0676	-0.1925	-0.161	0.2217	0.0273	-0.0221	0.3166	0.0518	0.332	0.5317	-5.1859	30.9809
149	4.7548	-5.7492	4.3971	6.9275	-5.6347	4.2275	-0.3673	0.4791	0.1401	-0.0587	0.8087	0.4332	-0.8109	0.4842	-0.1102	0.3468	0.028	0.0809	0.45	0.0886	0.3813	-0.199	8.7438	16.0274
150	4.3063	3.1999	-0.1546	8.0725	-3.2966	5.1426	-0.0186	0.3817	0.1047	-0.0449	0.3071	0.6628	-0.296	-0.3377	-0.2652	0.2147	0.0384	0.0096	0.4705	0.0578	0.3444	-6.3094	4.526	22.9372
151	3.965	-3.7777	2.678	6.6707	0.2721	6.3912	0.1713	0.0404	0.4604	-0.5875	-0.5125	0.0838	-0.4421	0.2607	0.211	0.2792	-0.0592	0.0481	0.468	0.0476	0.3264	5.0075	3.3755	10.6055
152	2.1933	5.6054	-6.0704	4.7174	-1.2957	5.19	-0.9828	1.3531	-0.2072	-1.1127	1.3064	0.3568	0.8125	-0.7092	-0.4279	0.6405	-0.0093	-0.1112	0.6581	-0.0354	0.4301	7.962	-11.7663	7.2619
153	6.2676	-1.4779	0.8011	4.1778	4.9368	7.0946	1.1342	-0.071	-0.0859	-0.2689	-0.632	-1.0636	-1.1482	0.2218	-0.3174	0.9528	-0.2303	-0.0585	1.2893	0.2392	0.746	13.1645	5.7779	-0.361
154	2.0831	0.491	-0.8781	8.5365	-4.4028	4.7179	-0.0259	0.0787	0.2057	-0.3741	-0.0379	0.3556	0.3902	0.272	0.1279	0.198	0.016	-0.0136	0.4173	0.0045	0.2735	6.267	-8.4769	18.3967
155	4.9226	5.6668	-5.5567	5.9323	-6.0379	7.0471	-1.0628	1.1725	-1.8905	-1.2632	-0.2563	-1.403	0.5742	0.7962	1.117	0.4258	-0.0469	0.0753	0.7138	-0.0151	0.419	15.9562	-10.9213	13.9809
156	7.1144	5.9707	-5.1382	9.7522	-3.4439	7.5188	-0.5351	-0.2648	-0.2227	-0.7547	0.1633	-0.8703	0.1307	1.2181	0.3675	0.2695	-0.0539	0.0608	0.5415	-0.0256	0.3575	21.9238	-7.5847	14.457
157	7.6804	6.5311	-2.6499	4.9117	-0.0811	7.5151	0.3112	0.0744	0.3376	0.9401	-0.367	0.7993	-0.191	-0.0544	-0.1066	0.1619	0.0077	0.0072	0.2887	-0.0219	0.3118	6.3937	-9.6981	26.2517
158	3.1573	-3.5908	-3.9942	9.9168	9.4756	9.2423	0.6261	-0.6871	0.0509	-1.2549	-0.8169	-0.0529	-1.9214	0.486	0.3985	0.3629	-0.0251	0.0689	0.5609	0.1155	0.3779	16.4642	0.6913	11.6026
159	2.6494	-0.679	-0.8935	2.7581	-2.0354	4.5898	0.083	0.4732	-0.1603	-0.2628	-0.1126	0.1089	0.0637	0.1338	0.0347	0.2524	-0.0207	-0.0191	0.4452	0.0095	0.236	8.6551	-7.0861	13.0283
160	7.7817	-3.7893	1.0826	2.1995	-1.5218	7.4953	0.2413	0.3511	0.493	-0.6199	-0.1577	0.3748	-0.3644	0.2983	0.0705	0.3039	-0.0349	0.0352	0.4571	-0.0166	0.3036	24.1412	-0.557	16.2807
161	9.1283	7.0055	-6.2451	5.4576	-4.6159	9.6386	-0.9695	-0.1887	-1.3901	0.6271	0.9932	-0.5505	0.3093	0.1809	-0.0054	0.3828	0.1434	0.0343	0.5265	0.0825	0.5768	31.7955	-11.6022	24.7678
162	1.6279	-0.2889	-3.1416	5.0479	-1.0806	9.2353	-0.7886	1.8565	0.8312	-0.7516	0.6315	-3.323	-0.2668	1.4459	-0.3456	0.913	-0.2794	0.1822	1.166	-0.0026	1.2471	37.3543	4.773	16.0395
163	3.3815	-1.7443	-2.2328	2.2407	-1.6316	7.2194	0.2201	0.1187	0.4367	0.0208	-0.1551	0.0362	-0.6741	0.3894	-0.0756	0.2143	-0.0467	-0.003	0.4124	0.0433	0.2751	23.1232	-0.7459	22.9883
164	6.8116	-0.1042	-4.5056	2.0679	-0.1832	3.0034	-0.5309	-0.5952	-1.4269	-0.6289	-0.63	0.2205	-0.4167	0.3469	1.2712	0.3825	0.0402	-0.0362	0.4281	-0.0135	0.57	18.4802	-20.6121	31.6654
165	4.7154	2.895	-2.8225	2.7403	-3.8187	6.2602	0.9351	-0.8837	-0.7973	1.718	-0.7981	-1.8191	-0.6744	0.9298	-0.1012	0.2575	-0.07	-0.0144	0.5656	0.0667	0.5073	28.7439	-5.7884	32.9957
166	7.2961	3.7195	-1.0002	4.7535	-3.9944	4.244	0.4828	-1.1853	0.8973	0.6826	-0.6131	0.1192	-0.4575	0.3843	0.2278	0.2961	-0.0023	0.0306	0.3795	-0.1038	0.4677	30.0545	0.3878	35.7031
167	3.4556	3.1481	-3.0343	2.9222	-2.8471	2.6749	0.4525	0.3769	1.2234	0.4158	0.2905	0.2073	-0.0807	-0.0555	-0.4449	0.2994	-0.0369	0.0198	0.3224	0.0116	0.3984	12.4166	-15.2683	33.3041
168	4.6949	2.0375	-0.9632	7.0132	-1.9413	2.9768	0.1565	-0.3887	0.0314	0.2474	-0.3159	-0.3335	-0.0862	0.3582	0.1291	0.1997	-0.0327	-0.0097	0.3936	0.0195	0.1897	25.4203	-5.3027	28.8401
169	9.2249	4.2493	-2.1828	4.4602	-5.6413	8.2672	-0.2932	0.4272	0.3065	-0.4797	0.1284	-0.0372	0.0197	0.4445	0.0179	0.2466	0.0511	0.0548	0.387	0.0171	0.2171	24.3001	-0.773	18.8286
170	4.9042	2.799	-3.7866	5.5173	0.2256	4.4616	0.1383	-0.012	0.4647	0.0796	-0.2052	-0.3829	-1.3434	1.0148	0.525	0.3923	-0.1371	-0.0331	0.469	0.0864	0.4266	27.4796	7.5254	34.6485
171	9.5705	6.1329	-6.3861	5.7015	-7.464	9.6125	0.2046	0.3111	-0.2889	0.4434	-0.1563	-0.7553	-0.4481	-0.0798	-0.1	0.4185	-0.0427	-0.0711	0.5586	-0.0411	0.3522	25.2474	3.5678	49.4493
172	1.1812	2.3528	0.9173	4.2451	1.6761	0.7125	-0.1649	-0.0135	0.7317	2.46	-0.023	-3.748	-3.0646	2.1708	1.0535	1.0925	-0.2477	-0.1938	0.9918	-0.1113	1.2719	31.3524	19.8596	39.4355
173	4.1157	2.2317	-2.6071	4.9095	-2.7215	5.0777	0.0663	0.2893	0.5244	-0.2558	0.3656	-0.1063	-0.471	0.0409	-0.3757	0.2968	-0.0106	0.0484	0.3645	0.0232	0.2919	20.6332	5.455	36.8108
174	2.1279	0.3048	-2.7968	1.9688	-1.4284	6.6862	0.4733	-0.8091	-1.1306	-0.1493	-0.172	0.373	-0.0542	0.4303	-0.363	0.4724	-0.0197	-0.0536	0.3568	0.0849	0.3686	16.0994	-11.4681	47.8507
175	4.7278	3.6325	-2.2746	4.0687	-4.7192	6.6342	-0.1302	-0.1089	0.9659	1.6518	0.7492	0.5209	-0.6561	-0.0447	-0.4465	0.3614	-0.0691	-0.0277	0.3719	-0.0037	0.3973	15.2889	6.6768	47.6579
176	2.8027	1.7329	1.0654	3.2138	-1.6297	2.8647	-0.767	-0.8174	2.7353	0.3503	0.0159	0.6721	-2.8942	-0.8333	0.308	0.8481	0.0258	-0.0297	0.5533	-0.0835	0.7026	11.5053	22.8813	46.2318
177	1.3236	0.6533	0.7995	3.8741	5.9195	7.7238	-0.0807	-0.2268	-0.0974	-0.3856	0.1685	-0.1442	-0.1782	-0.0152	-0.0898	0.2845	-0.0602	0.0339	0.2733	0.0354	0.2719	11.7344	-0.7929	44.2568
178	6.2272	4.6492	-2.5649	5.5301	-4.3559	4.0423	-0.3806	0.462	0.5561	0.4694	1.3056	0.4376	-0.434	-0.091	-0.8007	0.3455	-0.0102	0.0402	0.3811	0.0247	0.3546	14.3714	0.7871	34.7328
179	9.1352	8.3526	5.4157	7.6806	4.9811	6.579	-0.3829	0.9758	0.2417	-0.2698	0.2821	0.77	-0.9694	1.3152	-0.0059	0.4019	0.0312	0.0144	0.3503	0.0179	0.3832	19.2203	13.5988	39.2552
180	7.1028	4.3417	-2.696	3.3723	-3.7207	6.6505	0.7121	-0.9864	-0.1126	1.1238	-0.4583	0.611	-0.0633	0.1658	-0.2487	0.3115	-0.129	-0.017	0.3612	0.0597	0.3023	18.3356	1.29	49.6934
181	6.6229	7.5255	-2.2268	9.5382	-3.1801	6.4974	0.2044	0.0774	0.4114	0.3008	0.4475	0.8454	-0.4566	0.0807	-0.4546	0.2815	-0.0227	0.0146	0.3328	0.0185	0.4128	24.8156	6.1937	36.223

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Selection details
1	X-RAY DIFFRACTION	1	chain 'A' and (resid 14 through 23 )
2	X-RAY DIFFRACTION	2	chain 'A' and (resid 24 through 31 )
3	X-RAY DIFFRACTION	3	chain 'A' and (resid 32 through 39 )
4	X-RAY DIFFRACTION	4	chain 'A' and (resid 40 through 57 )
5	X-RAY DIFFRACTION	5	chain 'A' and (resid 58 through 65 )
6	X-RAY DIFFRACTION	6	chain 'A' and (resid 66 through 91 )
7	X-RAY DIFFRACTION	7	chain 'A' and (resid 92 through 108 )
8	X-RAY DIFFRACTION	8	chain 'A' and (resid 109 through 119 )
9	X-RAY DIFFRACTION	9	chain 'B' and (resid 14 through 23 )
10	X-RAY DIFFRACTION	10	chain 'B' and (resid 24 through 31 )
11	X-RAY DIFFRACTION	11	chain 'B' and (resid 32 through 39 )
12	X-RAY DIFFRACTION	12	chain 'B' and (resid 40 through 57 )
13	X-RAY DIFFRACTION	13	chain 'B' and (resid 58 through 65 )
14	X-RAY DIFFRACTION	14	chain 'B' and (resid 66 through 79 )
15	X-RAY DIFFRACTION	15	chain 'B' and (resid 80 through 85 )
16	X-RAY DIFFRACTION	16	chain 'B' and (resid 86 through 91 )
17	X-RAY DIFFRACTION	17	chain 'B' and (resid 92 through 97 )
18	X-RAY DIFFRACTION	18	chain 'B' and (resid 98 through 118 )
19	X-RAY DIFFRACTION	19	chain 'C' and (resid 13 through 23 )
20	X-RAY DIFFRACTION	20	chain 'C' and (resid 24 through 38 )
21	X-RAY DIFFRACTION	21	chain 'C' and (resid 39 through 49 )
22	X-RAY DIFFRACTION	22	chain 'C' and (resid 50 through 65 )
23	X-RAY DIFFRACTION	23	chain 'C' and (resid 66 through 91 )
24	X-RAY DIFFRACTION	24	chain 'C' and (resid 92 through 108 )
25	X-RAY DIFFRACTION	25	chain 'C' and (resid 109 through 119 )
26	X-RAY DIFFRACTION	26	chain 'D' and (resid 14 through 23 )
27	X-RAY DIFFRACTION	27	chain 'D' and (resid 24 through 31 )
28	X-RAY DIFFRACTION	28	chain 'D' and (resid 32 through 39 )
29	X-RAY DIFFRACTION	29	chain 'D' and (resid 40 through 49 )
30	X-RAY DIFFRACTION	30	chain 'D' and (resid 50 through 57 )
31	X-RAY DIFFRACTION	31	chain 'D' and (resid 58 through 65 )
32	X-RAY DIFFRACTION	32	chain 'D' and (resid 66 through 79 )
33	X-RAY DIFFRACTION	33	chain 'D' and (resid 80 through 91 )
34	X-RAY DIFFRACTION	34	chain 'D' and (resid 92 through 97 )
35	X-RAY DIFFRACTION	35	chain 'D' and (resid 98 through 108 )
36	X-RAY DIFFRACTION	36	chain 'D' and (resid 109 through 118 )
37	X-RAY DIFFRACTION	37	chain 'E' and (resid 14 through 23 )
38	X-RAY DIFFRACTION	38	chain 'E' and (resid 24 through 31 )
39	X-RAY DIFFRACTION	39	chain 'E' and (resid 32 through 49 )
40	X-RAY DIFFRACTION	40	chain 'E' and (resid 50 through 65 )
41	X-RAY DIFFRACTION	41	chain 'E' and (resid 66 through 91 )
42	X-RAY DIFFRACTION	42	chain 'E' and (resid 92 through 97 )
43	X-RAY DIFFRACTION	43	chain 'E' and (resid 98 through 108 )
44	X-RAY DIFFRACTION	44	chain 'E' and (resid 109 through 119 )
45	X-RAY DIFFRACTION	45	chain 'F' and (resid 13 through 23 )
46	X-RAY DIFFRACTION	46	chain 'F' and (resid 24 through 31 )
47	X-RAY DIFFRACTION	47	chain 'F' and (resid 32 through 49 )
48	X-RAY DIFFRACTION	48	chain 'F' and (resid 50 through 65 )
49	X-RAY DIFFRACTION	49	chain 'F' and (resid 66 through 79 )
50	X-RAY DIFFRACTION	50	chain 'F' and (resid 80 through 91 )
51	X-RAY DIFFRACTION	51	chain 'F' and (resid 92 through 97 )
52	X-RAY DIFFRACTION	52	chain 'F' and (resid 98 through 108 )
53	X-RAY DIFFRACTION	53	chain 'F' and (resid 109 through 119 )
54	X-RAY DIFFRACTION	54	chain 'G' and (resid 14 through 23 )
55	X-RAY DIFFRACTION	55	chain 'G' and (resid 24 through 31 )
56	X-RAY DIFFRACTION	56	chain 'G' and (resid 32 through 39 )
57	X-RAY DIFFRACTION	57	chain 'G' and (resid 40 through 49 )
58	X-RAY DIFFRACTION	58	chain 'G' and (resid 50 through 65 )
59	X-RAY DIFFRACTION	59	chain 'G' and (resid 66 through 70 )
60	X-RAY DIFFRACTION	60	chain 'G' and (resid 71 through 85 )
61	X-RAY DIFFRACTION	61	chain 'G' and (resid 86 through 97 )
62	X-RAY DIFFRACTION	62	chain 'G' and (resid 98 through 108 )
63	X-RAY DIFFRACTION	63	chain 'G' and (resid 109 through 119 )
64	X-RAY DIFFRACTION	64	chain 'H' and (resid 13 through 23 )
65	X-RAY DIFFRACTION	65	chain 'H' and (resid 24 through 31 )
66	X-RAY DIFFRACTION	66	chain 'H' and (resid 32 through 39 )
67	X-RAY DIFFRACTION	67	chain 'H' and (resid 40 through 57 )
68	X-RAY DIFFRACTION	68	chain 'H' and (resid 58 through 65 )
69	X-RAY DIFFRACTION	69	chain 'H' and (resid 66 through 70 )
70	X-RAY DIFFRACTION	70	chain 'H' and (resid 71 through 85 )
71	X-RAY DIFFRACTION	71	chain 'H' and (resid 86 through 97 )
72	X-RAY DIFFRACTION	72	chain 'H' and (resid 98 through 119 )
73	X-RAY DIFFRACTION	73	chain 'I' and (resid 13 through 23 )
74	X-RAY DIFFRACTION	74	chain 'I' and (resid 24 through 38 )
75	X-RAY DIFFRACTION	75	chain 'I' and (resid 39 through 49 )
76	X-RAY DIFFRACTION	76	chain 'I' and (resid 50 through 65 )
77	X-RAY DIFFRACTION	77	chain 'I' and (resid 66 through 79 )
78	X-RAY DIFFRACTION	78	chain 'I' and (resid 80 through 91 )
79	X-RAY DIFFRACTION	79	chain 'I' and (resid 92 through 97 )
80	X-RAY DIFFRACTION	80	chain 'I' and (resid 98 through 119 )
81	X-RAY DIFFRACTION	81	chain 'J' and (resid 14 through 23 )
82	X-RAY DIFFRACTION	82	chain 'J' and (resid 24 through 31 )
83	X-RAY DIFFRACTION	83	chain 'J' and (resid 32 through 38 )
84	X-RAY DIFFRACTION	84	chain 'J' and (resid 39 through 49 )
85	X-RAY DIFFRACTION	85	chain 'J' and (resid 50 through 65 )
86	X-RAY DIFFRACTION	86	chain 'J' and (resid 66 through 70 )
87	X-RAY DIFFRACTION	87	chain 'J' and (resid 71 through 91 )
88	X-RAY DIFFRACTION	88	chain 'J' and (resid 92 through 108 )
89	X-RAY DIFFRACTION	89	chain 'J' and (resid 109 through 120 )
90	X-RAY DIFFRACTION	90	chain 'a' and (resid 14 through 23 )
91	X-RAY DIFFRACTION	91	chain 'a' and (resid 24 through 31 )
92	X-RAY DIFFRACTION	92	chain 'a' and (resid 32 through 39 )
93	X-RAY DIFFRACTION	93	chain 'a' and (resid 40 through 57 )
94	X-RAY DIFFRACTION	94	chain 'a' and (resid 58 through 65 )
95	X-RAY DIFFRACTION	95	chain 'a' and (resid 66 through 70 )
96	X-RAY DIFFRACTION	96	chain 'a' and (resid 71 through 85 )
97	X-RAY DIFFRACTION	97	chain 'a' and (resid 86 through 97 )
98	X-RAY DIFFRACTION	98	chain 'a' and (resid 98 through 108 )
99	X-RAY DIFFRACTION	99	chain 'a' and (resid 109 through 119 )
100	X-RAY DIFFRACTION	100	chain 'b' and (resid 14 through 23 )
101	X-RAY DIFFRACTION	101	chain 'b' and (resid 24 through 31 )
102	X-RAY DIFFRACTION	102	chain 'b' and (resid 32 through 39 )
103	X-RAY DIFFRACTION	103	chain 'b' and (resid 40 through 49 )
104	X-RAY DIFFRACTION	104	chain 'b' and (resid 50 through 65 )
105	X-RAY DIFFRACTION	105	chain 'b' and (resid 66 through 70 )
106	X-RAY DIFFRACTION	106	chain 'b' and (resid 71 through 85 )
107	X-RAY DIFFRACTION	107	chain 'b' and (resid 86 through 97 )
108	X-RAY DIFFRACTION	108	chain 'b' and (resid 98 through 118 )
109	X-RAY DIFFRACTION	109	chain 'c' and (resid 14 through 23 )
110	X-RAY DIFFRACTION	110	chain 'c' and (resid 24 through 31 )
111	X-RAY DIFFRACTION	111	chain 'c' and (resid 32 through 38 )
112	X-RAY DIFFRACTION	112	chain 'c' and (resid 39 through 57 )
113	X-RAY DIFFRACTION	113	chain 'c' and (resid 58 through 65 )
114	X-RAY DIFFRACTION	114	chain 'c' and (resid 66 through 79 )
115	X-RAY DIFFRACTION	115	chain 'c' and (resid 80 through 85 )
116	X-RAY DIFFRACTION	116	chain 'c' and (resid 86 through 97 )
117	X-RAY DIFFRACTION	117	chain 'c' and (resid 98 through 119 )
118	X-RAY DIFFRACTION	118	chain 'd' and (resid 13 through 23 )
119	X-RAY DIFFRACTION	119	chain 'd' and (resid 24 through 31 )
120	X-RAY DIFFRACTION	120	chain 'd' and (resid 32 through 38 )
121	X-RAY DIFFRACTION	121	chain 'd' and (resid 39 through 57 )
122	X-RAY DIFFRACTION	122	chain 'd' and (resid 58 through 65 )
123	X-RAY DIFFRACTION	123	chain 'd' and (resid 66 through 91 )
124	X-RAY DIFFRACTION	124	chain 'd' and (resid 92 through 97 )
125	X-RAY DIFFRACTION	125	chain 'd' and (resid 98 through 119 )
126	X-RAY DIFFRACTION	126	chain 'e' and (resid 13 through 23 )
127	X-RAY DIFFRACTION	127	chain 'e' and (resid 24 through 49 )
128	X-RAY DIFFRACTION	128	chain 'e' and (resid 50 through 65 )
129	X-RAY DIFFRACTION	129	chain 'e' and (resid 66 through 91 )
130	X-RAY DIFFRACTION	130	chain 'e' and (resid 92 through 108 )
131	X-RAY DIFFRACTION	131	chain 'e' and (resid 109 through 119 )
132	X-RAY DIFFRACTION	132	chain 'f' and (resid 14 through 23 )
133	X-RAY DIFFRACTION	133	chain 'f' and (resid 24 through 31 )
134	X-RAY DIFFRACTION	134	chain 'f' and (resid 32 through 38 )
135	X-RAY DIFFRACTION	135	chain 'f' and (resid 39 through 49 )
136	X-RAY DIFFRACTION	136	chain 'f' and (resid 50 through 65 )
137	X-RAY DIFFRACTION	137	chain 'f' and (resid 66 through 79 )
138	X-RAY DIFFRACTION	138	chain 'f' and (resid 80 through 91 )
139	X-RAY DIFFRACTION	139	chain 'f' and (resid 92 through 97 )
140	X-RAY DIFFRACTION	140	chain 'f' and (resid 98 through 108 )
141	X-RAY DIFFRACTION	141	chain 'f' and (resid 109 through 119 )
142	X-RAY DIFFRACTION	142	chain 'g' and (resid 14 through 23 )
143	X-RAY DIFFRACTION	143	chain 'g' and (resid 24 through 31 )
144	X-RAY DIFFRACTION	144	chain 'g' and (resid 32 through 38 )
145	X-RAY DIFFRACTION	145	chain 'g' and (resid 39 through 49 )
146	X-RAY DIFFRACTION	146	chain 'g' and (resid 50 through 65 )
147	X-RAY DIFFRACTION	147	chain 'g' and (resid 66 through 79 )
148	X-RAY DIFFRACTION	148	chain 'g' and (resid 80 through 91 )
149	X-RAY DIFFRACTION	149	chain 'g' and (resid 92 through 97 )
150	X-RAY DIFFRACTION	150	chain 'g' and (resid 98 through 119 )
151	X-RAY DIFFRACTION	151	chain 'h' and (resid 13 through 23 )
152	X-RAY DIFFRACTION	152	chain 'h' and (resid 24 through 31 )
153	X-RAY DIFFRACTION	153	chain 'h' and (resid 32 through 39 )
154	X-RAY DIFFRACTION	154	chain 'h' and (resid 40 through 57 )
155	X-RAY DIFFRACTION	155	chain 'h' and (resid 58 through 65 )
156	X-RAY DIFFRACTION	156	chain 'h' and (resid 66 through 79 )
157	X-RAY DIFFRACTION	157	chain 'h' and (resid 80 through 91 )
158	X-RAY DIFFRACTION	158	chain 'h' and (resid 92 through 97 )
159	X-RAY DIFFRACTION	159	chain 'h' and (resid 98 through 118 )
160	X-RAY DIFFRACTION	160	chain 'i' and (resid 13 through 23 )
161	X-RAY DIFFRACTION	161	chain 'i' and (resid 24 through 31 )
162	X-RAY DIFFRACTION	162	chain 'i' and (resid 32 through 38 )
163	X-RAY DIFFRACTION	163	chain 'i' and (resid 39 through 49 )
164	X-RAY DIFFRACTION	164	chain 'i' and (resid 50 through 57 )
165	X-RAY DIFFRACTION	165	chain 'i' and (resid 58 through 65 )
166	X-RAY DIFFRACTION	166	chain 'i' and (resid 66 through 79 )
167	X-RAY DIFFRACTION	167	chain 'i' and (resid 80 through 85 )
168	X-RAY DIFFRACTION	168	chain 'i' and (resid 86 through 108 )
169	X-RAY DIFFRACTION	169	chain 'i' and (resid 109 through 119 )
170	X-RAY DIFFRACTION	170	chain 'j' and (resid 13 through 23 )
171	X-RAY DIFFRACTION	171	chain 'j' and (resid 24 through 31 )
172	X-RAY DIFFRACTION	172	chain 'j' and (resid 32 through 39 )
173	X-RAY DIFFRACTION	173	chain 'j' and (resid 40 through 49 )
174	X-RAY DIFFRACTION	174	chain 'j' and (resid 50 through 57 )
175	X-RAY DIFFRACTION	175	chain 'j' and (resid 58 through 65 )
176	X-RAY DIFFRACTION	176	chain 'j' and (resid 66 through 70 )
177	X-RAY DIFFRACTION	177	chain 'j' and (resid 71 through 85 )
178	X-RAY DIFFRACTION	178	chain 'j' and (resid 86 through 91 )
179	X-RAY DIFFRACTION	179	chain 'j' and (resid 92 through 97 )
180	X-RAY DIFFRACTION	180	chain 'j' and (resid 98 through 108 )
181	X-RAY DIFFRACTION	181	chain 'j' and (resid 109 through 118 )