regulation of protein deubiquitination / negative regulation of cytoplasmic pattern recognition receptor signaling pathway / ubiquitin-like protein transferase activity / negative regulation of defense response to virus / cellular response to tumor cell / protein K29-linked ubiquitination / nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway / T cell anergy / positive regulation of T cell anergy / cellular response to oxidised low-density lipoprotein particle stimulus ...regulation of protein deubiquitination / negative regulation of cytoplasmic pattern recognition receptor signaling pathway / ubiquitin-like protein transferase activity / negative regulation of defense response to virus / cellular response to tumor cell / protein K29-linked ubiquitination / nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway / T cell anergy / positive regulation of T cell anergy / cellular response to oxidised low-density lipoprotein particle stimulus / CXCR chemokine receptor binding / regulation of necroptotic process / CD4-positive, alpha-beta T cell proliferation / negative regulation of cell division / negative regulation of CD4-positive, alpha-beta T cell proliferation / negative regulation of JNK cascade / HECT-type E3 ubiquitin transferase / arrestin family protein binding / enzyme inhibitor activity / Regulation of FOXO transcriptional activity by acetylation / regulation of hematopoietic stem cell differentiation / negative regulation of type I interferon production / positive regulation of receptor catabolic process / negative regulation of NF-kappaB transcription factor activity / ubiquitin-like protein ligase binding / protein monoubiquitination / ligase activity / protein K63-linked ubiquitination / platelet-derived growth factor receptor signaling pathway / The NLRP3 inflammasome / protein autoubiquitination / protein K48-linked ubiquitination / ribonucleoprotein complex binding / Purinergic signaling in leishmaniasis infection / response to glucose / response to mechanical stimulus / keratinocyte differentiation / Downregulation of ERBB4 signaling / Activated NOTCH1 Transmits Signal to the Nucleus / Negative regulators of DDX58/IFIH1 signaling / response to progesterone / regulation of cell growth / Degradation of GLI1 by the proteasome / Hedgehog 'on' state / NOD1/2 Signaling Pathway / response to hydrogen peroxide / Regulation of necroptotic cell death / receptor internalization / Cytoprotection by HMOX1 / response to calcium ion / positive regulation of protein catabolic process / protein import into nucleus / ubiquitin-protein transferase activity / SARS-CoV-1 activates/modulates innate immune responses / ubiquitin protein ligase activity / protein transport / Antigen processing: Ubiquitination & Proteasome degradation / response to estradiol / RUNX1 regulates transcription of genes involved in differentiation of HSCs / regulation of cell population proliferation / cell cortex / early endosome membrane / cytoplasmic vesicle / ubiquitin-dependent protein catabolic process / proteasome-mediated ubiquitin-dependent protein catabolic process / defense response to virus / protein ubiquitination / response to xenobiotic stimulus / inflammatory response / symbiont entry into host cell / positive regulation of apoptotic process / cell cycle / intracellular membrane-bounded organelle / innate immune response / apoptotic process / ubiquitin protein ligase binding / negative regulation of apoptotic process / negative regulation of transcription by RNA polymerase II / protein-containing complex / mitochondrion / extracellular exosome / nucleoplasm / membrane / plasma membrane / cytoplasm / cytosol Similarity search - Function
Resolution: 1.65→30 Å / Cross valid method: THROUGHOUT Details: COOT WAS USED FOR INTERACTIVE MODEL BUILDING. MODEL GEOMETRY WAS EVALUATED WITH MOLPROBITY.
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.257
1252
5.1 %
THIN SHELLS (SFTOOLS)
Rwork
0.222
-
-
-
obs
0.224
23283
97.8 %
-
Displacement parameters
Biso mean: 26.23 Å2
Baniso -1
Baniso -2
Baniso -3
1-
-0.43 Å2
0 Å2
0.44 Å2
2-
-
-1.33 Å2
0 Å2
3-
-
-
1.16 Å2
Refinement step
Cycle: LAST / Resolution: 1.65→30 Å
Protein
Nucleic acid
Ligand
Solvent
Total
Num. atoms
1505
0
30
73
1608
LS refinement shell
Resolution: 1.65→1.69 Å
Rfactor
Num. reflection
% reflection
Rwork
0.248
1778
-
obs
-
-
96.84 %
+
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