登録情報 データベース : PDB / ID : 5crw 構造の表示 ダウンロードとリンクタイトル Crystal structure of the b'-a' domain of oxidized protein disulfide isomerase complexed with alpha-synuclein peptide (31-41) 要素Peptide from Alpha-synuclein Protein disulfide-isomerase 詳細キーワード ISOMERASE/METAL BINDING PROTEIN / THIOREDOXIN FOLD / ISOMERASE / DISULFIDE BOND / ENDOPLASMIC RETICULUM / THIOREDOXIN / OXIDOREDUCTASE / ISOMERASE-METAL BINDING PROTEIN complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
protein disulfide-isomerase / negative regulation of mitochondrial electron transport, NADH to ubiquinone / neutral lipid metabolic process / regulation of phospholipase activity / negative regulation of monooxygenase activity / regulation of acyl-CoA biosynthetic process / negative regulation of dopamine uptake involved in synaptic transmission / negative regulation of norepinephrine uptake / positive regulation of glutathione peroxidase activity / positive regulation of SNARE complex assembly ... protein disulfide-isomerase / negative regulation of mitochondrial electron transport, NADH to ubiquinone / neutral lipid metabolic process / regulation of phospholipase activity / negative regulation of monooxygenase activity / regulation of acyl-CoA biosynthetic process / negative regulation of dopamine uptake involved in synaptic transmission / negative regulation of norepinephrine uptake / positive regulation of glutathione peroxidase activity / positive regulation of SNARE complex assembly / positive regulation of hydrogen peroxide catabolic process / supramolecular fiber / negative regulation of transporter activity / mitochondrial membrane organization / negative regulation of chaperone-mediated autophagy / regulation of reactive oxygen species biosynthetic process / positive regulation of protein localization to cell periphery / regulation of synaptic vesicle recycling / negative regulation of platelet-derived growth factor receptor signaling pathway / negative regulation of exocytosis / regulation of glutamate secretion / regulation of norepinephrine uptake / response to iron(II) ion / SNARE complex assembly / positive regulation of neurotransmitter secretion / dopamine biosynthetic process / regulation of locomotion / positive regulation of inositol phosphate biosynthetic process / synaptic vesicle priming / regulation of macrophage activation / negative regulation of microtubule polymerization / dopamine uptake involved in synaptic transmission / synaptic vesicle transport / dynein complex binding / positive regulation of receptor recycling / protein disulfide isomerase activity / regulation of dopamine secretion / protein kinase inhibitor activity / negative regulation of thrombin-activated receptor signaling pathway / response to type II interferon / cuprous ion binding / synaptic vesicle exocytosis / positive regulation of exocytosis / kinesin binding / positive regulation of endocytosis / mitochondrial ATP synthesis coupled electron transport / cysteine-type endopeptidase inhibitor activity involved in apoptotic process / response to magnesium ion / regulation of presynapse assembly / synaptic vesicle endocytosis / negative regulation of serotonin uptake / alpha-tubulin binding / localization / phospholipid metabolic process / supramolecular fiber organization / axon terminus / inclusion body / cellular response to copper ion / cellular response to epinephrine stimulus / Hsp70 protein binding / excitatory postsynaptic potential / response to endoplasmic reticulum stress / response to interleukin-1 / adult locomotory behavior / SNARE binding / positive regulation of release of sequestered calcium ion into cytosol / fatty acid metabolic process / long-term synaptic potentiation / phosphoprotein binding / protein tetramerization / regulation of transmembrane transporter activity / synapse organization / regulation of long-term neuronal synaptic plasticity / microglial cell activation / negative regulation of protein kinase activity / protein destabilization / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / ferrous iron binding / tau protein binding / PKR-mediated signaling / positive regulation of protein serine/threonine kinase activity / receptor internalization / phospholipid binding / synaptic vesicle membrane / positive regulation of inflammatory response / activation of cysteine-type endopeptidase activity involved in apoptotic process / actin cytoskeleton / protein folding / positive regulation of peptidyl-serine phosphorylation / actin binding / cell cortex / histone binding / cellular response to oxidative stress / growth cone / postsynapse / chemical synaptic transmission / neuron apoptotic process / negative regulation of neuron apoptotic process / amyloid fibril formation / response to lipopolysaccharide 類似検索 - 分子機能 Protein disulphide isomerase / Thioredoxin-like domain / Disulphide isomerase / Synuclein / Alpha-synuclein / Synuclein / Endoplasmic reticulum targeting sequence. / Thioredoxin / Thioredoxin, conserved site / Thioredoxin family active site. ... Protein disulphide isomerase / Thioredoxin-like domain / Disulphide isomerase / Synuclein / Alpha-synuclein / Synuclein / Endoplasmic reticulum targeting sequence. / Thioredoxin / Thioredoxin, conserved site / Thioredoxin family active site. / Thioredoxin domain profile. / Thioredoxin domain / Glutaredoxin / Glutaredoxin / Thioredoxin-like superfamily / 3-Layer(aba) Sandwich / Alpha Beta 類似検索 - ドメイン・相同性 Alpha-synuclein / Alpha-synuclein / Protein disulfide-isomerase 類似検索 - 構成要素生物種 Humicola insolens (菌類)Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.6 Å 詳細データ登録者 Yagi-Utsumi, M. / Satoh, T. / Kato, K. 資金援助 日本, 1件 詳細 詳細を隠す組織 認可番号 国 JSPS/MEXT 15K21680, 24770102, 25102001, 25102008, 25121730 日本
引用ジャーナル : Sci Rep / 年 : 2015タイトル : Structural basis of redox-dependent substrate binding of protein disulfide isomerase.著者 : Yagi-Utsumi, M. / Satoh, T. / Kato, K. 履歴 登録 2015年7月23日 登録サイト : RCSB / 処理サイト : PDBJ改定 1.0 2015年9月9日 Provider : repository / タイプ : Initial release改定 1.1 2015年9月23日 Group : Database references改定 1.2 2018年2月7日 Group : Data collection / Database references / Derived calculationsカテゴリ : citation / diffrn_source / pdbx_struct_oper_listItem : _citation.title / _diffrn_source.pdbx_synchrotron_site / _pdbx_struct_oper_list.symmetry_operation改定 1.3 2023年11月8日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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