Entry | Database: PDB / ID: 5cr6 |
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Title | Structure of pneumolysin at 1.98 A resolution |
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Components | Pneumolysin |
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Keywords | TOXIN / cholesterol-dependent cytolysin / virulence factor / Streptococcus pneumoniae |
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Function / homology | Function and homology information
cholesterol binding / toxin activity / killing of cells of another organism / host cell plasma membrane / extracellular region / membraneSimilarity search - Function Perfringolysin, domain 4 / Thiol-activated cytolysins signature. / Thiol-activated cytolysin C-terminal / Thiol-activated cytolysin, C-terminal domain superfamily / Thiol-activated cytolysin beta sandwich domain / Thiol-activated cytolysin / Thiol-activated cytolysin superfamily / Thiol-activated cytolysin, alpha-beta domain superfamily / Thiol-activated cytolysin / Immunoglobulin-like ...Perfringolysin, domain 4 / Thiol-activated cytolysins signature. / Thiol-activated cytolysin C-terminal / Thiol-activated cytolysin, C-terminal domain superfamily / Thiol-activated cytolysin beta sandwich domain / Thiol-activated cytolysin / Thiol-activated cytolysin superfamily / Thiol-activated cytolysin, alpha-beta domain superfamily / Thiol-activated cytolysin / Immunoglobulin-like / Sandwich / Mainly BetaSimilarity search - Domain/homology |
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Biological species | Streptococcus pneumoniae (bacteria) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 1.98 Å |
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Authors | Marshall, J.E. / Faraj, B.H.A. / Gingras, A.R. / Lonnen, R. / Sheikh, M.A. / El-Mezgueldi, M. / Moody, P.C.E. / Andrew, P.W. / Wallis, R. |
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Funding support | United Kingdom, 2items Organization | Grant number | Country |
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Wellcome Trust | 097828/z/11/z | United Kingdom | Medical Research Council (United Kingdom) | PhD project grant | United Kingdom |
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Citation | Journal: Sci Rep / Year: 2015 Title: The Crystal Structure of Pneumolysin at 2.0 angstrom Resolution Reveals the Molecular Packing of the Pre-pore Complex. Authors: Marshall, J.E. / Faraj, B.H. / Gingras, A.R. / Lonnen, R. / Sheikh, M.A. / El-Mezgueldi, M. / Moody, P.C. / Andrew, P.W. / Wallis, R. |
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History | Deposition | Jul 22, 2015 | Deposition site: RCSB / Processing site: PDBE |
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Revision 1.0 | Sep 16, 2015 | Provider: repository / Type: Initial release |
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Revision 1.1 | Aug 30, 2017 | Group: Author supporting evidence / Derived calculations Category: pdbx_audit_support / struct_sheet / struct_sheet_range Item: _pdbx_audit_support.funding_organization |
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Revision 1.2 | Jan 10, 2024 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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