Entry | Database: PDB / ID: 5cr8 |
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Title | Structure of the membrane-binding domain of pneumolysin |
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Components | Pneumolysin |
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Keywords | TOXIN / cholesterol-dependent cytolysin / virulence factor / hydrolase |
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Function / homology | Function and homology information
hemolysis in another organism / cholesterol binding / : / toxin activity / killing of cells of another organism / membrane => GO:0016020 / host cell plasma membrane / extracellular region / membraneSimilarity search - Function Perfringolysin, domain 4 / Thiol-activated cytolysins signature. / Thiol-activated cytolysin C-terminal / Thiol-activated cytolysin, C-terminal domain superfamily / Thiol-activated cytolysin beta sandwich domain / Thiol-activated cytolysin / Thiol-activated cytolysin superfamily / Thiol-activated cytolysin, alpha-beta domain superfamily / Thiol-activated cytolysin / Immunoglobulin-like ...Perfringolysin, domain 4 / Thiol-activated cytolysins signature. / Thiol-activated cytolysin C-terminal / Thiol-activated cytolysin, C-terminal domain superfamily / Thiol-activated cytolysin beta sandwich domain / Thiol-activated cytolysin / Thiol-activated cytolysin superfamily / Thiol-activated cytolysin, alpha-beta domain superfamily / Thiol-activated cytolysin / Immunoglobulin-like / Sandwich / Mainly BetaSimilarity search - Domain/homology |
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Biological species | Streptococcus pneumoniae (bacteria) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 2.05 Å |
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Authors | Marshall, J.E. / Faraj, B.H.A. / Gingras, A.R. / Lonnen, R. / Sheikh, M.A. / El-Mezgueldi, M. / Moody, P.C.E. / Andrew, P.W. / Wallis, R. |
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Citation | Journal: Sci Rep / Year: 2015 Title: The Crystal Structure of Pneumolysin at 2.0 angstrom Resolution Reveals the Molecular Packing of the Pre-pore Complex. Authors: Marshall, J.E. / Faraj, B.H. / Gingras, A.R. / Lonnen, R. / Sheikh, M.A. / El-Mezgueldi, M. / Moody, P.C. / Andrew, P.W. / Wallis, R. |
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History | Deposition | Jul 22, 2015 | Deposition site: RCSB / Processing site: PDBE |
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Revision 1.0 | Sep 16, 2015 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jan 10, 2024 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id |
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