Entry Database : PDB / ID : 5c5h Structure visualization Downloads & linksTitle R195K E. coli MenE with bound OSB-AMS Components2-succinylbenzoate--CoA ligase Details Keywords LIGASEFunction / homology Function and homology informationFunction Domain/homology Component
o-succinylbenzoate-CoA ligase / o-succinylbenzoate-CoA ligase activity / menaquinone biosynthetic process / protein-containing complex / ATP binding / identical protein binding Similarity search - Function 2-succinylbenzoate--CoA ligase / ANL, N-terminal domain / AMP-binding enzyme, C-terminal domain / AMP-binding enzyme C-terminal domain / AMP-binding, conserved site / Putative AMP-binding domain signature. / AMP-dependent synthetase/ligase / AMP-binding enzyme, C-terminal domain superfamily / AMP-binding enzyme Similarity search - Domain/homologyBiological species Escherichia coli (E. coli)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.401 Å DetailsAuthors Matarlo, J.S. / Shek, R. / Rajashankar, K.R. / Tonge, P.J. / French, J.B. Funding support United States, 2items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) GM102864 United States National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) GM103403 United States
CitationJournal : Biochemistry / Year : 2015Title : Mechanism of MenE Inhibition by Acyl-Adenylate Analogues and Discovery of Novel Antibacterial Agents.Authors : Matarlo, J.S. / Evans, C.E. / Sharma, I. / Lavaud, L.J. / Ngo, S.C. / Shek, R. / Rajashankar, K.R. / French, J.B. / Tan, D.S. / Tonge, P.J. History Deposition Jun 19, 2015 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Oct 7, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Nov 4, 2015 Group : Database referencesRevision 1.2 Sep 6, 2017 Group : Author supporting evidence / Database references / Derived calculationsCategory : citation / pdbx_audit_support / pdbx_struct_oper_listItem : _citation.journal_id_CSD / _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operationRevision 1.3 Dec 25, 2019 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.4 Sep 27, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_symmetry
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