- PDB-5bt2: MeCP2 MBD domain (A140V) in complex with methylated DNA -
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基本情報
登録情報
データベース: PDB / ID: 5bt2
タイトル
MeCP2 MBD domain (A140V) in complex with methylated DNA
要素
DNA (5'-D(*AP*TP*AP*GP*AP*AP*GP*AP*AP*TP*TP*CP*(5CM)P*GP*TP*TP*CP*CP*AP*G)-3')
DNA (5'-D(*TP*CP*TP*GP*GP*AP*AP*(5CM)P*GP*GP*AP*AP*TP*TP*CP*TP*TP*CP*TP*A)-3')
Methyl-CpG-binding protein 2
キーワード
DNA BINDING PROTEIN/DNA / A/T run / MeCP2 / hydration spine / methylated DNA / DNA BINDING PROTEIN-DNA complex
機能・相同性
機能・相同性情報
trans-synaptic signaling by BDNF / regulation of action potential firing threshold / negative regulation of respiratory gaseous exchange / Loss of MECP2 binding ability to 5hmC-DNA / cellular response to isoquinoline alkaloid / positive regulation of anterograde dense core granule transport / positive regulation of retrograde dense core granule transport / positive regulation of branching morphogenesis of a nerve / catecholamine secretion / MECP2 regulates transcription of genes involved in GABA signaling ...trans-synaptic signaling by BDNF / regulation of action potential firing threshold / negative regulation of respiratory gaseous exchange / Loss of MECP2 binding ability to 5hmC-DNA / cellular response to isoquinoline alkaloid / positive regulation of anterograde dense core granule transport / positive regulation of retrograde dense core granule transport / positive regulation of branching morphogenesis of a nerve / catecholamine secretion / MECP2 regulates transcription of genes involved in GABA signaling / biogenic amine metabolic process / negative regulation of dendrite extension / principal sensory nucleus of trigeminal nerve development / cardiolipin metabolic process / negative regulation of locomotion involved in locomotory behavior / Loss of MECP2 binding ability to 5mC-DNA / nervous system process involved in regulation of systemic arterial blood pressure / proprioception / negative regulation of primary miRNA processing / negative regulation of smooth muscle cell differentiation / MECP2 regulates transcription of neuronal ligands / Loss of MECP2 binding ability to the NCoR/SMRT complex / negative regulation of dendritic spine development / Transcriptional Regulation by MECP2 / regulation of respiratory gaseous exchange by nervous system process / double-stranded methylated DNA binding / ventricular cardiac muscle tissue development / inositol metabolic process / genomic imprinting / phosphatidylcholine metabolic process / thalamus development / positive regulation of microtubule nucleation / glucocorticoid metabolic process / ventricular system development / cellular response to potassium ion / unmethylated CpG binding / positive regulation of synaptic plasticity / oligodendrocyte development / respiratory gaseous exchange by respiratory system / olfactory bulb development / positive regulation of dendrite extension / striatum development / response to other organism / siRNA binding / neuron maturation / methyl-CpG binding / MECP2 regulates transcription factors / Loss of phosphorylation of MECP2 at T308 / negative regulation of gene expression via chromosomal CpG island methylation / response to ionizing radiation / spinal cord development / positive regulation of dendritic spine development / regulation of synapse organization / lung alveolus development / glutamine metabolic process / startle response / dendrite development / social behavior / negative regulation of blood vessel endothelial cell migration / Regulation of MECP2 expression and activity / negative regulation of astrocyte differentiation / behavioral fear response / glial cell proliferation / Nuclear events stimulated by ALK signaling in cancer / heterochromatin / long-term memory / heterochromatin formation / MECP2 regulates neuronal receptors and channels / four-way junction DNA binding / positive regulation of glial cell proliferation / Notch signaling pathway / sensory perception of pain / synapse assembly / histone reader activity / excitatory postsynaptic potential / negative regulation of angiogenesis / adult locomotory behavior / cerebellum development / post-embryonic development / molecular condensate scaffold activity / response to cocaine / long-term synaptic potentiation / promoter-specific chromatin binding / hippocampus development / response to lead ion / visual learning / protein localization / chromatin DNA binding / cerebral cortex development / histone deacetylase binding / transcription corepressor activity / response to estradiol / gene expression / postsynapse / negative regulation of neuron apoptotic process / nucleic acid binding / molecular adaptor activity / response to hypoxia / protein domain specific binding / negative regulation of gene expression 類似検索 - 分子機能
Methyl-CpG binding protein MeCP2 / Methyl-cpg-binding Protein 2; Chain A / Methyl-cpg-binding Protein 2; Chain A / Methyl-CpG binding protein MeCP2/MBD4 / Methyl-CpG binding domain / Methyl-CpG DNA binding / Methyl-CpG binding domain / Methyl-CpG-binding domain (MBD) profile. / DNA-binding domain superfamily / 2-Layer Sandwich / Alpha Beta 類似検索 - ドメイン・相同性
DNA / DNA (> 10) / Methyl-CpG-binding protein 2 類似検索 - 構成要素
A: Methyl-CpG-binding protein 2 B: DNA (5'-D(*TP*CP*TP*GP*GP*AP*AP*(5CM)P*GP*GP*AP*AP*TP*TP*CP*TP*TP*CP*TP*A)-3') C: DNA (5'-D(*AP*TP*AP*GP*AP*AP*GP*AP*AP*TP*TP*CP*(5CM)P*GP*TP*TP*CP*CP*AP*G)-3')
解像度: 2.2→48.5 Å / Cor.coef. Fo:Fc: 0.974 / Cor.coef. Fo:Fc free: 0.96 / SU B: 13.84 / SU ML: 0.179 / 交差検証法: THROUGHOUT / σ(F): 0 / ESU R: 0.246 / ESU R Free: 0.198 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD / 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
反射数
%反射
Selection details
Rfree
0.2266
525
5 %
RANDOM
Rwork
0.1746
-
-
-
obs
0.1773
9955
98.7 %
-
溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.2 Å / 溶媒モデル: MASK