Entry Database : PDB / ID : 4hca Structure visualization Downloads & linksTitle DNA binding by GATA transcription factor-complex 1 ComponentsDNA (5'-D(*AP*AP*TP*GP*TP*CP*CP*AP*TP*CP*TP*GP*AP*TP*AP*AP*GP*AP*CP*G)-3')DNA (5'-D(*TP*TP*CP*GP*TP*CP*TP*TP*AP*TP*CP*AP*GP*AP*TP*GP*GP*AP*CP*A)-3')Trans-acting T-cell-specific transcription factor GATA-3 DetailsKeywords Transcription/DNA / zinc finger / GATA transcription factor / DNA bridging / Transcription-DNA complexFunction / homology Function and homology informationFunction Domain/homology Component
nephric duct formation / negative regulation of cell proliferation involved in mesonephros development / regulation of cellular response to X-ray / negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation / negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation / ureter morphogenesis / thymic T cell selection / ureteric bud formation / positive regulation of ureteric bud formation / : ... nephric duct formation / negative regulation of cell proliferation involved in mesonephros development / regulation of cellular response to X-ray / negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation / negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation / ureter morphogenesis / thymic T cell selection / ureteric bud formation / positive regulation of ureteric bud formation / : / HMG box domain binding / positive regulation of thyroid hormone generation / otic vesicle development / anatomical structure formation involved in morphogenesis / pro-T cell differentiation / negative regulation of mammary gland epithelial cell proliferation / nephric duct morphogenesis / interleukin-2 receptor binding / norepinephrine biosynthetic process / cardiac right ventricle morphogenesis / cellular response to interferon-alpha / immune system development / parathyroid gland development / ureter maturation / mesenchymal to epithelial transition / mast cell differentiation / parathyroid hormone secretion / regulation of nephron tubule epithelial cell differentiation / regulation of epithelial cell differentiation / positive regulation of signal transduction / lymphocyte migration / mesonephros development / Formation of the nephric duct / positive regulation of T-helper 2 cell cytokine production / regulation of T-helper cell differentiation / ear development / positive regulation of interleukin-13 production / positive regulation of interleukin-5 production / pharyngeal system development / sympathetic nervous system development / negative regulation of cell motility / cellular response to BMP stimulus / cell fate determination / positive regulation of transcription regulatory region DNA binding / negative regulation of epithelial to mesenchymal transition / T-helper 2 cell differentiation / aortic valve morphogenesis / cartilage development / regulation of establishment of cell polarity / lens development in camera-type eye / positive regulation of T cell differentiation / embryonic hemopoiesis / ventricular septum development / negative regulation of interleukin-2 production / regulation of neuron projection development / inner ear morphogenesis / positive regulation of interleukin-4 production / E-box binding / uterus development / humoral immune response / macrophage differentiation / negative regulation of type II interferon production / negative regulation of cell cycle / T cell differentiation / developmental growth / TOR signaling / anatomical structure morphogenesis / canonical Wnt signaling pathway / cell fate commitment / embryonic organ development / cellular response to interleukin-4 / cis-regulatory region sequence-specific DNA binding / negative regulation of endothelial cell apoptotic process / regulation of neuron apoptotic process / cell maturation / regulation of cytokine production / positive regulation of endothelial cell migration / erythrocyte differentiation / phosphatidylinositol 3-kinase/protein kinase B signal transduction / post-embryonic development / thymus development / kidney development / axon guidance / neuron migration / response to virus / defense response / transcription coactivator binding / DNA-binding transcription repressor activity, RNA polymerase II-specific / positive regulation of miRNA transcription / negative regulation of inflammatory response / response to estrogen / male gonad development / sequence-specific double-stranded DNA binding / cellular response to tumor necrosis factor / RUNX1 regulates transcription of genes involved in differentiation of HSCs / T cell receptor signaling pathway / Factors involved in megakaryocyte development and platelet production / DNA-binding transcription activator activity, RNA polymerase II-specific / Interleukin-4 and Interleukin-13 signaling / Estrogen-dependent gene expression Similarity search - Function Transcription factor, GATA-2/3 / Transcription factor GATA / GATA-type zinc finger domain. / GATA-type zinc finger domain profile. / zinc finger binding to DNA consensus sequence [AT]GATA[AG] / GATA zinc finger / Zinc finger, GATA-type / Erythroid Transcription Factor GATA-1, subunit A / Erythroid Transcription Factor GATA-1; Chain A / Zinc finger, NHR/GATA-type ... Transcription factor, GATA-2/3 / Transcription factor GATA / GATA-type zinc finger domain. / GATA-type zinc finger domain profile. / zinc finger binding to DNA consensus sequence [AT]GATA[AG] / GATA zinc finger / Zinc finger, GATA-type / Erythroid Transcription Factor GATA-1, subunit A / Erythroid Transcription Factor GATA-1; Chain A / Zinc finger, NHR/GATA-type / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.8 Å DetailsAuthors Chen, Y. / Bates, D.L. / Dey, R. / Chen, L. CitationJournal : Cell Rep / Year : 2012Title : DNA Binding by GATA Transcription Factor Suggests Mechanisms of DNA Looping and Long-Range Gene Regulation.Authors : Chen, Y. / Bates, D.L. / Dey, R. / Chen, P.H. / Machado, A.C. / Laird-Offringa, I.A. / Rohs, R. / Chen, L. History Deposition Sep 28, 2012 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Dec 5, 2012 Provider : repository / Type : Initial releaseRevision 1.1 Jan 2, 2013 Group : Database referencesRevision 1.2 Feb 28, 2024 Group : Data collection / Database references / Derived calculationsCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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