登録情報 データベース : PDB / ID : 4zvz 構造の表示 ダウンロードとリンクタイトル Co-crystal structures of PP5 in complex with 5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid 要素Serine/threonine-protein phosphatase 5 詳細 キーワード Hydrolase/Hydrolase Inhibitor / Protein phosphatase 5 / Hydrolase-Hydrolase Inhibitor complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway / response to arachidonate / peptidyl-threonine dephosphorylation / peptidyl-serine dephosphorylation / proximal dendrite / mitogen-activated protein kinase kinase kinase binding / protein folding chaperone complex / response to morphine / cellular response to cadmium ion / protein-serine/threonine phosphatase ... positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway / response to arachidonate / peptidyl-threonine dephosphorylation / peptidyl-serine dephosphorylation / proximal dendrite / mitogen-activated protein kinase kinase kinase binding / protein folding chaperone complex / response to morphine / cellular response to cadmium ion / protein-serine/threonine phosphatase / protein serine/threonine phosphatase activity / phosphatase activity / phosphoprotein phosphatase activity / protein serine/threonine kinase inhibitor activity / G-protein alpha-subunit binding / protein dephosphorylation / negative regulation of MAPK cascade / Hsp70 protein binding / ESR-mediated signaling / Hsp90 protein binding / response to lead ion / ADP binding / tau protein binding / Negative regulation of MAPK pathway / cellular response to hydrogen peroxide / MAPK cascade / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / double-strand break repair / mitotic cell cycle / perikaryon / microtubule binding / positive regulation of canonical NF-kappaB signal transduction / intracellular membrane-bounded organelle / DNA-templated transcription / lipid binding / negative regulation of apoptotic process / protein-containing complex binding / protein-containing complex / RNA binding / nucleoplasm / ATP binding / metal ion binding / identical protein binding / nucleus / plasma membrane / cytosol 類似検索 - 分子機能 PP5, C-terminal metallophosphatase domain / PPP domain / PPP5 TPR repeat region / : / Serine/threonine specific protein phosphatases signature. / Protein phosphatase 2A homologues, catalytic domain. / Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase / Metallo-dependent phosphatases / Purple Acid Phosphatase; chain A, domain 2 / Tetratricopeptide repeat ... PP5, C-terminal metallophosphatase domain / PPP domain / PPP5 TPR repeat region / : / Serine/threonine specific protein phosphatases signature. / Protein phosphatase 2A homologues, catalytic domain. / Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase / Metallo-dependent phosphatases / Purple Acid Phosphatase; chain A, domain 2 / Tetratricopeptide repeat / Calcineurin-like phosphoesterase domain, ApaH type / Calcineurin-like phosphoesterase / Metallo-dependent phosphatase-like / TPR repeat region circular profile. / TPR repeat profile. / Tetratricopeptide repeats / Tetratricopeptide repeat / 4-Layer Sandwich / Tetratricopeptide-like helical domain superfamily / Alpha Beta 類似検索 - ドメイン・相同性 Chem-4TF / : / DI(HYDROXYETHYL)ETHER / Serine/threonine-protein phosphatase 5 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2 Å 詳細データ登録者 Chattopadhyay, D. / Swingle, M.R. / Salter, E.A. / Wierzbicki, A. / Honkanen, R.E. 引用ジャーナル : Biochem. Pharmacol. / 年 : 2016タイトル : Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.
著者: Chattopadhyay, D. / Swingle, M.R. / Salter, E.A. / Wood, E. / D'Arcy, B. / Zivanov, C. / Abney, K. / Musiyenko, A. / Rusin, S.F. / Kettenbach, A. / Yet, L. / Schroeder, C.E. / Golden, J.E. / ... 著者 : Chattopadhyay, D. / Swingle, M.R. / Salter, E.A. / Wood, E. / D'Arcy, B. / Zivanov, C. / Abney, K. / Musiyenko, A. / Rusin, S.F. / Kettenbach, A. / Yet, L. / Schroeder, C.E. / Golden, J.E. / Dunham, W.H. / Gingras, A.C. / Banerjee, S. / Forbes, D. / Wierzbicki, A. / Honkanen, R.E. 残り1件を表示 表示を減らす履歴 登録 2015年5月18日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2016年4月27日 Provider : repository / タイプ : Initial release改定 1.1 2017年2月8日 Group : Database references改定 1.2 2023年9月27日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_ncs_dom_lim Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_symmetry / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id
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