Entry | Database: PDB / ID: 4zvv |
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Title | Lactate dehydrogenase A in complex with a trisubstituted piperidine-2,4-dione inhibitor GNE-140 |
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Components | L-lactate dehydrogenase A chain |
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Keywords | Oxidoreductase/Oxidoreductase Inhibitor / oxidoreductase inhibitor complex / LDHA-G02792140 / Oxidoreductase-Oxidoreductase Inhibitor complex |
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Function / homology | Function and homology information
oxidoreductase complex / Pyruvate metabolism / L-lactate dehydrogenase / lactate metabolic process / L-lactate dehydrogenase activity / pyruvate metabolic process / substantia nigra development / glycolytic process / cadherin binding / mitochondrion ...oxidoreductase complex / Pyruvate metabolism / L-lactate dehydrogenase / lactate metabolic process / L-lactate dehydrogenase activity / pyruvate metabolic process / substantia nigra development / glycolytic process / cadherin binding / mitochondrion / extracellular exosome / identical protein binding / membrane / nucleus / cytosolSimilarity search - Function L-lactate dehydrogenase active site. / L-lactate dehydrogenase / L-lactate dehydrogenase, active site / L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2 / Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal / L-lactate/malate dehydrogenase / Lactate/malate dehydrogenase, N-terminal / Lactate/malate dehydrogenase, C-terminal / lactate/malate dehydrogenase, NAD binding domain / lactate/malate dehydrogenase, alpha/beta C-terminal domain ...L-lactate dehydrogenase active site. / L-lactate dehydrogenase / L-lactate dehydrogenase, active site / L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2 / Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal / L-lactate/malate dehydrogenase / Lactate/malate dehydrogenase, N-terminal / Lactate/malate dehydrogenase, C-terminal / lactate/malate dehydrogenase, NAD binding domain / lactate/malate dehydrogenase, alpha/beta C-terminal domain / Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal / NAD(P)-binding Rossmann-like Domain / NAD(P)-binding domain superfamily / Alpha-Beta Complex / Rossmann fold / 3-Layer(aba) Sandwich / Alpha BetaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.2 Å |
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Authors | Li, Y. / Chen, Z. / Eigenbrot, C. |
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Citation | Journal: Nat.Chem.Biol. / Year: 2016 Title: Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition. Authors: Boudreau, A. / Purkey, H.E. / Hitz, A. / Robarge, K. / Peterson, D. / Labadie, S. / Kwong, M. / Hong, R. / Gao, M. / Del Nagro, C. / Pusapati, R. / Ma, S. / Salphati, L. / Pang, J. / Zhou, A. ...Authors: Boudreau, A. / Purkey, H.E. / Hitz, A. / Robarge, K. / Peterson, D. / Labadie, S. / Kwong, M. / Hong, R. / Gao, M. / Del Nagro, C. / Pusapati, R. / Ma, S. / Salphati, L. / Pang, J. / Zhou, A. / Lai, T. / Li, Y. / Chen, Z. / Wei, B. / Yen, I. / Sideris, S. / McCleland, M. / Firestein, R. / Corson, L. / Vanderbilt, A. / Williams, S. / Daemen, A. / Belvin, M. / Eigenbrot, C. / Jackson, P.K. / Malek, S. / Hatzivassiliou, G. / Sampath, D. / Evangelista, M. / O'Brien, T. |
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History | Deposition | May 18, 2015 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | May 18, 2016 | Provider: repository / Type: Initial release |
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Revision 1.1 | Aug 10, 2016 | Group: Database references |
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Revision 1.2 | Sep 28, 2016 | Group: Database references |
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Revision 1.3 | Sep 27, 2023 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_oper_list Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_oper_list.symmetry_operation |
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