Thyroidhormonereceptorbeta / Nuclear receptor subfamily 1 group A member 2 / c-erbA-2 / c-erbA-beta
Mass: 28525.033 Da / Num. of mol.: 1 / Fragment: ligand binding domain unp residues 210-461 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: THRB, ERBA2, NR1A2, THR1 / Production host: Escherichia coli (E. coli) / Strain (production host): BL21(DE3) / References: UniProt: P10828
#2: Protein/peptide
Nuclearreceptorcoactivator2 / NCoA-2 / Class E basic helix-loop-helix protein 75 / bHLHe75 / Transcriptional intermediary factor 2 / hTIF2
Mass: 1162.493 Da / Num. of mol.: 1 / Source method: obtained synthetically / Details: This sequence occurs naturally in humans / Source: (synth.) Homo sapiens (human) / References: UniProt: Q15596*PLUS
#3: Protein
RetinoicacidreceptorRXR-alpha / Nuclear receptor subfamily 2 group B member 1 / Retinoid X receptor alpha
Mass: 25224.316 Da / Num. of mol.: 1 / Fragment: ligand binding domain, unp residues 231-455 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P19793
#4: Chemical
ChemComp-T3 / 3,5,3'TRIIODOTHYRONINE / T3 / THYROID HORMONE / LIOTHYRONINE
Mass: 650.973 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C15H12I3NO4 / Comment: hormone*YM
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Experimental details
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Experiment
Experiment
Method: X-RAY DIFFRACTION / Number of used crystals: 1
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Sample preparation
Crystal
Density Matthews: 2.37 Å3/Da / Density % sol: 48.2 %
Crystal grow
Temperature: 294 K / Method: vapor diffusion, hanging drop / pH: 8 Details: 20% PEG 3350, 100 mM Tris pH 8.0, 0.1 M ammonium acetate, and 1 mM Methoprene acid
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