Entry Database : PDB / ID : 2acl Structure visualization Downloads & linksTitle Liver X-Receptor alpha Ligand Binding Domain with SB313987 ComponentsOxysterols receptor LXR-alpha Retinoic acid receptor RXR-alpha DetailsKeywords TRANSCRIPTION / nuclear hormone receptor ligand binding domain transcription factor three layered a-helix foldFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of secretion of lysosomal enzymes / NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis / sterol response element binding / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / SUMOylation of intracellular receptors / negative regulation of pancreatic juice secretion / Nuclear Receptor transcription pathway / phosphatidylcholine acyl-chain remodeling / cellular lipid metabolic process / negative regulation of response to endoplasmic reticulum stress ... negative regulation of secretion of lysosomal enzymes / NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis / sterol response element binding / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / SUMOylation of intracellular receptors / negative regulation of pancreatic juice secretion / Nuclear Receptor transcription pathway / phosphatidylcholine acyl-chain remodeling / cellular lipid metabolic process / negative regulation of response to endoplasmic reticulum stress / negative regulation of pinocytosis / negative regulation of macrophage activation / sterol homeostasis / VLDLR internalisation and degradation / positive regulation of toll-like receptor 4 signaling pathway / regulation of fatty acid metabolic process / positive regulation of triglyceride biosynthetic process / positive regulation of transporter activity / retinoic acid-responsive element binding / NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis / NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose / NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake / positive regulation of thyroid hormone receptor signaling pathway / NR1H2 & NR1H3 regulate gene expression linked to lipogenesis / positive regulation of fatty acid biosynthetic process / negative regulation of lipid transport / Carnitine metabolism / ion binding / Regulation of pyruvate dehydrogenase (PDH) complex / retinoic acid binding / positive regulation of vitamin D receptor signaling pathway / triglyceride homeostasis / nuclear vitamin D receptor binding / apoptotic cell clearance / negative regulation of cold-induced thermogenesis / Signaling by Retinoic Acid / DNA binding domain binding / nuclear steroid receptor activity / NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis / LBD domain binding / negative regulation of cholesterol storage / lipid homeostasis / Synthesis of bile acids and bile salts / positive regulation of cholesterol efflux / retinoic acid receptor signaling pathway / Endogenous sterols / Synthesis of bile acids and bile salts via 27-hydroxycholesterol / positive regulation of bone mineralization / Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol / nuclear retinoid X receptor binding / response to retinoic acid / Recycling of bile acids and salts / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / peroxisome proliferator activated receptor signaling pathway / RORA activates gene expression / positive regulation of protein metabolic process / Regulation of lipid metabolism by PPARalpha / hormone-mediated signaling pathway / BMAL1:CLOCK,NPAS2 activates circadian gene expression / Activation of gene expression by SREBF (SREBP) / transcription coregulator binding / response to progesterone / cholesterol homeostasis / nuclear receptor binding / negative regulation of proteolysis / RNA polymerase II transcription regulatory region sequence-specific DNA binding / peptide binding / Heme signaling / SUMOylation of intracellular receptors / mRNA transcription by RNA polymerase II / Transcriptional activation of mitochondrial biogenesis / PPARA activates gene expression / Cytoprotection by HMOX1 / chromatin DNA binding / fatty acid biosynthetic process / negative regulation of inflammatory response / Transcriptional regulation of white adipocyte differentiation / Activation of anterior HOX genes in hindbrain development during early embryogenesis / Nuclear Receptor transcription pathway / Transcriptional regulation of granulopoiesis / RNA polymerase II transcription regulator complex / nuclear receptor activity / sequence-specific double-stranded DNA binding / Circadian Clock / double-stranded DNA binding / DNA-binding transcription activator activity, RNA polymerase II-specific / cellular response to lipopolysaccharide / transcription regulator complex / sequence-specific DNA binding / cell differentiation / receptor complex / transcription cis-regulatory region binding / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of DNA-templated transcription / protein-containing complex binding / regulation of DNA-templated transcription / chromatin / nucleolus Similarity search - Function Liver X receptor / Nuclear/hormone receptor activator site AF-1 / Nuclear/hormone receptor activator site AF-1 / Retinoid X receptor/HNF4 / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) ... Liver X receptor / Nuclear/hormone receptor activator site AF-1 / Nuclear/hormone receptor activator site AF-1 / Retinoid X receptor/HNF4 / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.8 Å DetailsAuthors Jaye, M.C. / Krawiec, J.A. / Campobasso, N. / Smallwood, A. / Qiu, C. / Lu, Q. / Kerrigan, J.J. CitationJournal : J.Med.Chem. / Year : 2005Title : Discovery of substituted maleimides as liver x receptor agonists and determination of a ligand-bound crystal structure.Authors: Jaye, M.C. / Krawiec, J.A. / Campobasso, N. / Smallwood, A. / Qiu, C. / Lu, Q. / Kerrigan, J.J. / De Los Frailes Alvaro, M. / Laffitte, B. / Liu, W.S. / Marino, J.P. / Meyer, C.R. / Nichols, ... Authors : Jaye, M.C. / Krawiec, J.A. / Campobasso, N. / Smallwood, A. / Qiu, C. / Lu, Q. / Kerrigan, J.J. / De Los Frailes Alvaro, M. / Laffitte, B. / Liu, W.S. / Marino, J.P. / Meyer, C.R. / Nichols, J.A. / Parks, D.J. / Perez, P. / Sarov-Blat, L. / Seepersaud, S.D. / Steplewski, K.M. / Thompson, S.K. / Wang, P. / Watson, M.A. / Webb, C.L. / Haigh, D. / Caravella, J.A. / Macphee, C.H. / Willson, T.M. / Collins, J.L. History Deposition Jul 19, 2005 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Sep 20, 2005 Provider : repository / Type : Initial releaseRevision 1.1 Apr 30, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Feb 14, 2024 Group : Data collection / Database references / Derived calculationsCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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