登録情報 データベース : PDB / ID : 4zjv 構造の表示 ダウンロードとリンクタイトル crystal structure of EGFR kinase domain in complex with Mitogen-inducible gene 6 protein 要素ERBB receptor feedback inhibitor 1 Epidermal growth factor receptor 詳細キーワード TRANSFERASE/INHIBITOR / Epidermal growth factor receptor (EGFR) / ERBB receptor feedback inhibitor 1 / Mitogen-inducible gene 6 protein(Mig6) / TRANSFERASE-INHIBITOR complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
response to 1-oleoyl-sn-glycerol 3-phosphate / uterine epithelium development / limb joint morphogenesis / negative regulation of epidermal growth factor-activated receptor activity / regulation of type B pancreatic cell proliferation / lung epithelium development / regulation of keratinocyte differentiation / negative regulation of protein autophosphorylation / chondrocyte proliferation / lung vasculature development ... response to 1-oleoyl-sn-glycerol 3-phosphate / uterine epithelium development / limb joint morphogenesis / negative regulation of epidermal growth factor-activated receptor activity / regulation of type B pancreatic cell proliferation / lung epithelium development / regulation of keratinocyte differentiation / negative regulation of protein autophosphorylation / chondrocyte proliferation / lung vasculature development / bile acid biosynthetic process / skin morphogenesis / negative regulation of collagen biosynthetic process / tissue homeostasis / cellular hyperosmotic response / cartilage development / positive regulation of protein kinase C activity / multivesicular body, internal vesicle lumen / negative regulation of cardiocyte differentiation / response to hydroxyisoflavone / diterpenoid metabolic process / positive regulation of prolactin secretion / Shc-EGFR complex / Inhibition of Signaling by Overexpressed EGFR / ovulation cycle / EGFR interacts with phospholipase C-gamma / positive regulation of mucus secretion / negative regulation of cardiac muscle hypertrophy in response to stress / regulation of peptidyl-tyrosine phosphorylation / epidermal growth factor binding / fat pad development / tongue development / response to UV-A / negative regulation of interleukin-1 beta production / lung alveolus development / PLCG1 events in ERBB2 signaling / midgut development / ERBB2-EGFR signaling pathway / hydrogen peroxide metabolic process / morphogenesis of an epithelial fold / PTK6 promotes HIF1A stabilization / ERBB2 Activates PTK6 Signaling / digestive tract morphogenesis / Signaling by EGFR / response to cobalamin / intracellular vesicle / negative regulation of epidermal growth factor receptor signaling pathway / eyelid development in camera-type eye / cerebral cortex cell migration / protein insertion into membrane / ERBB2 Regulates Cell Motility / protein tyrosine kinase activator activity / Respiratory syncytial virus (RSV) attachment and entry / positive regulation of bone resorption / Signaling by ERBB4 / PI3K events in ERBB2 signaling / negative regulation of mitotic cell cycle / negative regulation of tumor necrosis factor production / positive regulation of phosphorylation / placental growth factor receptor activity / hepatocyte growth factor receptor activity / boss receptor activity / stem cell factor receptor activity / platelet-derived growth factor beta-receptor activity / brain-derived neurotrophic factor receptor activity / positive regulation of peptidyl-serine phosphorylation / platelet-derived growth factor alpha-receptor activity / epidermal growth factor receptor activity / hair follicle development / macrophage colony-stimulating factor receptor activity / peptidyl-tyrosine autophosphorylation / Estrogen-dependent nuclear events downstream of ESR-membrane signaling / protein tyrosine kinase collagen receptor activity / MAP kinase kinase kinase activity / positive regulation of G1/S transition of mitotic cell cycle / GAB1 signalosome / transmembrane-ephrin receptor activity / insulin-like growth factor receptor activity / embryonic placenta development / vascular endothelial growth factor receptor activity / GPI-linked ephrin receptor activity / salivary gland morphogenesis / progesterone receptor signaling pathway / positive regulation of vasoconstriction / fibroblast growth factor receptor activity / insulin receptor activity / cellular response to platelet-derived growth factor stimulus / Signaling by ERBB2 / positive regulation of glial cell proliferation / TFAP2 (AP-2) family regulates transcription of growth factors and their receptors / transmembrane receptor protein tyrosine kinase activity / GRB2 events in EGFR signaling / SHC1 events in EGFR signaling / EGFR Transactivation by Gastrin / embryo implantation / cellular response to dexamethasone stimulus / GRB2 events in ERBB2 signaling / positive regulation of synaptic transmission, glutamatergic / SHC1 events in ERBB2 signaling / cholesterol metabolic process 類似検索 - 分子機能 Cdc42 binding domain-like / Mig-6 domain / : / GTPase binding / EGFR receptor inhibitor Mig-6 / : / Epidermal growth factor receptor transmembrane-juxtamembrane segment / Tyrosine protein kinase, EGF/ERB/XmrK receptor / Growth factor receptor domain 4 / Growth factor receptor domain IV ... Cdc42 binding domain-like / Mig-6 domain / : / GTPase binding / EGFR receptor inhibitor Mig-6 / : / Epidermal growth factor receptor transmembrane-juxtamembrane segment / Tyrosine protein kinase, EGF/ERB/XmrK receptor / Growth factor receptor domain 4 / Growth factor receptor domain IV / Receptor L-domain / Furin-like cysteine-rich domain / Receptor L-domain superfamily / Furin-like cysteine rich region / Receptor L domain / Furin-like repeat / Furin-like repeats / Growth factor receptor cysteine-rich domain superfamily / : / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 Epidermal growth factor receptor / ERBB receptor feedback inhibitor 1 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.7 Å 詳細データ登録者 Eck, M.J. / Park, E. / Lee, B. 引用ジャーナル : Nat.Struct.Mol.Biol. / 年 : 2015タイトル : Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6.著者 : Park, E. / Kim, N. / Ficarro, S.B. / Zhang, Y. / Lee, B.I. / Cho, A. / Kim, K. / Park, A.K. / Park, W.Y. / Murray, B. / Meyerson, M. / Beroukhim, R. / Marto, J.A. / Cho, J. / Eck, M.J. 履歴 登録 2015年4月29日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2015年8月12日 Provider : repository / タイプ : Initial release改定 1.1 2015年8月26日 Group : Database references改定 1.2 2015年9月16日 Group : Database references改定 1.3 2023年9月27日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_oper_list Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_oper_list.symmetry_operation改定 1.4 2023年11月15日 Group : Data collection / カテゴリ : chem_comp_atom / chem_comp_bond / Item : _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_2改定 1.5 2024年11月20日 Group : Structure summaryカテゴリ : pdbx_entry_details / pdbx_modification_feature
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