Entry Database : PDB / ID : 4zfl Structure visualization Downloads & linksTitle Ergothioneine-biosynthetic Ntn hydrolase variant EgtC_C2A with natural substrate ComponentsAmidohydrolase EgtC Details Keywords HYDROLASE / Ntn hydrolase / ergothioneine biosynthesis / sulfur chemistry / MycobacteriaFunction / homology Function and homology informationFunction Domain/homology Component
gamma-glutamyl hercynylcysteine S-oxide hydrolase / ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide / hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides / glutamine metabolic process Similarity search - Function Ergothioneine biosynthesis protein EgtC / Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase, Actinobacteria / Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase EgtC-like / Glutamine amidotransferases class-II / Glutamine amidotransferase domain / Glutamine amidotransferase type 2 domain profile. / Glutamine amidotransferase type 2 domain / Aminohydrolase, N-terminal nucleophile (Ntn) domain / Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1 / Nucleophile aminohydrolases, N-terminal ... Ergothioneine biosynthesis protein EgtC / Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase, Actinobacteria / Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase EgtC-like / Glutamine amidotransferases class-II / Glutamine amidotransferase domain / Glutamine amidotransferase type 2 domain profile. / Glutamine amidotransferase type 2 domain / Aminohydrolase, N-terminal nucleophile (Ntn) domain / Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1 / Nucleophile aminohydrolases, N-terminal / 4-Layer Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Mycobacterium smegmatis (bacteria)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 1.7 Å DetailsAuthors Vit, A. / Seebeck, F.P. / Blankenfeldt, W. Funding support Switzerland, 1items Details Hide detailsOrganization Grant number Country Swiss National Science Foundation 147005 Switzerland
CitationJournal : Chembiochem / Year : 2015Title : Structure of the Ergothioneine-Biosynthesis Amidohydrolase EgtC.Authors : Vit, A. / Mashabela, G.T. / Blankenfeldt, W. / Seebeck, F.P. History Deposition Apr 21, 2015 Deposition site : RCSB / Processing site : PDBERevision 1.0 Jul 1, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Jul 15, 2015 Group : Database referencesRevision 1.2 Sep 6, 2017 Group : Author supporting evidence / Data collection / Category : diffrn_radiation_wavelength / pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.3 Jan 10, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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