Entry Database : PDB / ID : 4z8m Structure visualization Downloads & linksTitle Crystal structure of the MAVS-TRAF6 complex ComponentsPeptide from Mitochondrial antiviral-signaling protein TNF receptor-associated factor 6 DetailsKeywords LIGASE/SIGNALING PROTEIN / Complex / Adaptor / E3 ligase / Antiviral signaling / LIGASE-SIGNALING PROTEIN complexFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of IP-10 production / regulation of peroxisome organization / RIG-I binding / protein kinase B binding / interleukin-17A-mediated signaling pathway / positive regulation of chemokine (C-C motif) ligand 5 production / MyD88 dependent cascade initiated on endosome / TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation / MyD88 cascade initiated on plasma membrane / interleukin-17-mediated signaling pathway ... positive regulation of IP-10 production / regulation of peroxisome organization / RIG-I binding / protein kinase B binding / interleukin-17A-mediated signaling pathway / positive regulation of chemokine (C-C motif) ligand 5 production / MyD88 dependent cascade initiated on endosome / TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation / MyD88 cascade initiated on plasma membrane / interleukin-17-mediated signaling pathway / positive regulation of myeloid dendritic cell cytokine production / interleukin-33-mediated signaling pathway / toll-like receptor 3 signaling pathway / positive regulation of transcription regulatory region DNA binding / CD40 receptor complex / CARD domain binding / positive regulation of lipopolysaccharide-mediated signaling pathway / TRIF-dependent toll-like receptor signaling pathway / myeloid dendritic cell differentiation / NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 / protein localization to mitochondrion / Regulated proteolysis of p75NTR / positive regulation of response to cytokine stimulus / positive regulation of osteoclast differentiation / positive regulation of type I interferon-mediated signaling pathway / tumor necrosis factor receptor binding / ubiquitin conjugating enzyme binding / regulation of immunoglobulin production / regulation of canonical NF-kappaB signal transduction / peroxisomal membrane / positive regulation of leukocyte adhesion to vascular endothelial cell / interleukin-1-mediated signaling pathway / MyD88-dependent toll-like receptor signaling pathway / ubiquitin-ubiquitin ligase activity / non-canonical NF-kappaB signal transduction / MyD88:MAL(TIRAP) cascade initiated on plasma membrane / toll-like receptor 4 signaling pathway / TRAF6 mediated IRF7 activation / negative regulation of type I interferon-mediated signaling pathway / positive regulation of NLRP3 inflammasome complex assembly / cytoplasmic pattern recognition receptor signaling pathway / T-helper 1 type immune response / negative regulation of viral genome replication / type I interferon-mediated signaling pathway / activation of protein kinase activity / cellular response to exogenous dsRNA / odontogenesis of dentin-containing tooth / cellular response to cytokine stimulus / stimulatory C-type lectin receptor signaling pathway / extrinsic component of cytoplasmic side of plasma membrane / Fc-epsilon receptor signaling pathway / TRAF6 mediated NF-kB activation / protein K63-linked ubiquitination / positive regulation of interferon-alpha production / autophagosome assembly / positive regulation of type I interferon production / protein autoubiquitination / bone resorption / canonical NF-kappaB signal transduction / signaling adaptor activity / ubiquitin ligase complex / positive regulation of T cell proliferation / antiviral innate immune response / positive regulation of defense response to virus by host / positive regulation of JUN kinase activity / lipopolysaccharide-mediated signaling pathway / tumor necrosis factor-mediated signaling pathway / IRAK2 mediated activation of TAK1 complex / Alpha-protein kinase 1 signaling pathway / IRAK1 recruits IKK complex / IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation / IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation / TICAM1,TRAF6-dependent induction of TAK1 complex / activation of innate immune response / positive regulation of interleukin-12 production / p75NTR recruits signalling complexes / positive regulation of interleukin-2 production / positive regulation of interferon-beta production / TRAF6-mediated induction of TAK1 complex within TLR4 complex / TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling / NF-kB is activated and signals survival / response to interleukin-1 / NRIF signals cell death from the nucleus / ossification / TICAM1, RIP1-mediated IKK complex recruitment / lipid droplet / osteoclast differentiation / IKK complex recruitment mediated by RIP1 / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / molecular condensate scaffold activity / positive regulation of protein ubiquitination / Regulation of NF-kappa B signaling / neural tube closure / positive regulation of interleukin-8 production / activated TAK1 mediates p38 MAPK activation / Negative regulators of DDX58/IFIH1 signaling / mitochondrial membrane / TAK1-dependent IKK and NF-kappa-B activation / NOD1/2 Signaling Pathway / DDX58/IFIH1-mediated induction of interferon-alpha/beta Similarity search - Function TNF receptor-associated factor 6, zinc finger 2 / TNF receptor-associated factor 6 zinc finger 2 / TNF receptor-associated factor 6 / TNF receptor-associated factor 6, MATH domain / : / IPS1, CARD domain / TRAF-type zinc finger / TNF receptor-associated factor TRAF, metazoa / Zinc finger, TRAF-type / Zinc finger TRAF-type profile. ... TNF receptor-associated factor 6, zinc finger 2 / TNF receptor-associated factor 6 zinc finger 2 / TNF receptor-associated factor 6 / TNF receptor-associated factor 6, MATH domain / : / IPS1, CARD domain / TRAF-type zinc finger / TNF receptor-associated factor TRAF, metazoa / Zinc finger, TRAF-type / Zinc finger TRAF-type profile. / : / TRAF/meprin, MATH domain / Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A / Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A / Zinc finger, C3HC4 type (RING finger) / Caspase recruitment domain / Caspase recruitment domain / MATH/TRAF domain / MATH/TRAF domain profile. / meprin and TRAF homology / TRAF-like / Zinc finger, RING-type, conserved site / Zinc finger RING-type signature. / Death-like domain superfamily / Ring finger / Zinc finger RING-type profile. / Zinc finger, RING-type / Zinc finger, RING/FYVE/PHD-type / Sandwich / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.95 Å DetailsAuthors Shi, Z.B. / Zhou, Z. CitationJournal : J.Biol.Chem. / Year : 2015Title : Structural Insights into Mitochondrial Antiviral Signaling Protein (MAVS)-Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) SignalingAuthors : Shi, Z. / Zhang, Z. / Zhang, Z. / Wang, Y. / Li, C. / Wang, X. / He, F. / Sun, L. / Jiao, S. / Shi, W. / Zhou, Z. History Deposition Apr 9, 2015 Deposition site : RCSB / Processing site : PDBJRevision 1.0 Sep 23, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Nov 4, 2015 Group : Database referencesRevision 1.2 Nov 11, 2015 Group : Database referencesRevision 1.3 Nov 8, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / citation / database_2 / pdbx_initial_refinement_model / pdbx_struct_oper_list Item : _citation.journal_id_CSD / _database_2.pdbx_DOI ... _citation.journal_id_CSD / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_oper_list.symmetry_operation
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