Entry | Database: PDB / ID: 6myd |
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Title | Structure of zebrafish TRAF6 in complex with STING CTT |
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Components | - STING CTT, Transmembrane protein 173
- TNF receptor-associated factor 6
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Keywords | IMMUNE SYSTEM / Innate Immunity / STING / NF-kappaB / TRAF6 / TMEM173 |
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Function / homology | Function and homology information
cytoplasmic pattern recognition receptor signaling pathway => GO:0002753 / STING mediated induction of host immune responses / STAT6-mediated induction of chemokines / : / Regulation of innate immune responses to cytosolic DNA / p75NTR recruits signalling complexes / Interleukin-1 signaling / NOD1/2 Signaling Pathway / Ovarian tumor domain proteases / Ub-specific processing proteases ...cytoplasmic pattern recognition receptor signaling pathway => GO:0002753 / STING mediated induction of host immune responses / STAT6-mediated induction of chemokines / : / Regulation of innate immune responses to cytosolic DNA / p75NTR recruits signalling complexes / Interleukin-1 signaling / NOD1/2 Signaling Pathway / Ovarian tumor domain proteases / Ub-specific processing proteases / Neutrophil degranulation / 2',3'-cyclic GMP-AMP binding / cyclic-di-GMP binding / tumor necrosis factor receptor binding / regulation of canonical NF-kappaB signal transduction / reticulophagy / non-canonical NF-kappaB signal transduction / autophagosome membrane / protein K63-linked ubiquitination / positive regulation of macroautophagy / autophagosome assembly / autophagosome / positive regulation of type I interferon production / lipopolysaccharide-mediated signaling pathway / positive regulation of defense response to virus by host / tumor necrosis factor-mediated signaling pathway / activation of innate immune response / endoplasmic reticulum-Golgi intermediate compartment membrane / lipid droplet / regulation of autophagy / response to bacterium / RING-type E3 ubiquitin transferase / response to virus / ubiquitin-protein transferase activity / ubiquitin protein ligase activity / cell cortex / cytoplasmic vesicle / regulation of apoptotic process / defense response to virus / membrane => GO:0016020 / innate immune response / endoplasmic reticulum membrane / positive regulation of DNA-templated transcription / perinuclear region of cytoplasm / endoplasmic reticulum / zinc ion binding / nucleus / cytoplasmSimilarity search - Function Stimulator of interferon genes protein, C-terminal / TNF receptor-associated factor 6 / TNF receptor-associated factor 6, MATH domain / TRAF-type zinc finger / TNF receptor-associated factor TRAF, metazoa / Zinc finger, TRAF-type / Zinc finger TRAF-type profile. / : / TRAF/meprin, MATH domain / Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A ...Stimulator of interferon genes protein, C-terminal / TNF receptor-associated factor 6 / TNF receptor-associated factor 6, MATH domain / TRAF-type zinc finger / TNF receptor-associated factor TRAF, metazoa / Zinc finger, TRAF-type / Zinc finger TRAF-type profile. / : / TRAF/meprin, MATH domain / Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A / Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A / Stimulator of interferon genes protein / Stimulator of interferon genes protein, C-terminal domain superfamily / Transmembrane protein 173 / MATH/TRAF domain / MATH/TRAF domain profile. / meprin and TRAF homology / TRAF-like / Zinc finger, C3HC4 RING-type / Zinc finger, C3HC4 type (RING finger) / Zinc finger, RING-type, conserved site / Zinc finger RING-type signature. / Ring finger / Zinc finger RING-type profile. / Zinc finger, RING-type / Zinc finger, RING/FYVE/PHD-type / Sandwich / Mainly BetaSimilarity search - Domain/homology |
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Biological species | Danio rerio (zebrafish) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.399 Å |
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Authors | de Oliveira Mann, C.C. / Orzalli, M.H. / King, D.S. / Kagan, J.C. / Lee, A.S.Y. / Kranzusch, P.J. |
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Citation | Journal: Cell Rep / Year: 2019 Title: Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-kappa B Signaling Adaptation. Authors: de Oliveira Mann, C.C. / Orzalli, M.H. / King, D.S. / Kagan, J.C. / Lee, A.S.Y. / Kranzusch, P.J. |
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History | Deposition | Nov 1, 2018 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | May 1, 2019 | Provider: repository / Type: Initial release |
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Revision 1.1 | Oct 11, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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