Entry Database : PDB / ID : 4z6i Structure visualization Downloads & linksTitle Crystal structure of BRD9 bromodomain in complex with a substituted valerolactam quinolone ligand ComponentsBromodomain-containing protein 9 Details Keywords TRANSCRIPTION / lysine-acetylated histone binding / chromatin regulator / Bromodomain / Structural Genomics / Structural Genomics Consortium / SGCFunction / homology Function and homology informationFunction Domain/homology Component
GBAF complex / SWI/SNF complex / positive regulation of stem cell population maintenance / negative regulation of cell differentiation / lysine-acetylated histone binding / nucleic acid binding / chromatin remodeling / positive regulation of cell population proliferation / chromatin / regulation of transcription by RNA polymerase II ... GBAF complex / SWI/SNF complex / positive regulation of stem cell population maintenance / negative regulation of cell differentiation / lysine-acetylated histone binding / nucleic acid binding / chromatin remodeling / positive regulation of cell population proliferation / chromatin / regulation of transcription by RNA polymerase II / nucleoplasm / nucleus Similarity search - Function Protein of unknown function DUF3512 / Domain of unknown function (DUF3512) / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Up-down Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.95 Å DetailsAuthors Tallant, C. / Structural Genomics Consortium (SGC) / Clark, P.G.K. / Vieira, L.C.C. / Newman, J.A. / Krojer, T. / Nunez-Alonso, G. / Picaud, S. / Fedorov, O. / Dixon, D.J. ...Tallant, C. / Structural Genomics Consortium (SGC) / Clark, P.G.K. / Vieira, L.C.C. / Newman, J.A. / Krojer, T. / Nunez-Alonso, G. / Picaud, S. / Fedorov, O. / Dixon, D.J. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Brennan, P.E. / Knapp, S. CitationJournal : Angew.Chem.Int.Ed.Engl. / Year : 2015Title : LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor.Authors: Clark, P.G. / Vieira, L.C. / Tallant, C. / Fedorov, O. / Singleton, D.C. / Rogers, C.M. / Monteiro, O.P. / Bennett, J.M. / Baronio, R. / Muller, S. / Daniels, D.L. / Mendez, J. / Knapp, S. / ... Authors : Clark, P.G. / Vieira, L.C. / Tallant, C. / Fedorov, O. / Singleton, D.C. / Rogers, C.M. / Monteiro, O.P. / Bennett, J.M. / Baronio, R. / Muller, S. / Daniels, D.L. / Mendez, J. / Knapp, S. / Brennan, P.E. / Dixon, D.J. History Deposition Apr 5, 2015 Deposition site : RCSB / Processing site : PDBERevision 1.0 May 20, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Jan 10, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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