Entry Database : PDB / ID : 4yyx Structure visualization Downloads & linksTitle Crystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin2 C-terminal tail ComponentsTight junction protein ZO-1 fused with Claudin-2 C-terminal Details Keywords CELL ADHESION / Tight junction / MAGUK / PDZ1 / SCAFFOLDING / ClaudinFunction / homology Function and homology informationFunction Domain/homology Component
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules / positive regulation of blood-brain barrier permeability / adherens junction maintenance / positive regulation of cell-cell adhesion mediated by cadherin / RUNX1 regulates expression of components of tight junctions / Tight junction interactions / SARS-CoV-2 targets PDZ proteins in cell-cell junction / establishment of endothelial intestinal barrier / protein localization to cell-cell junction / regulation of cell junction assembly ... calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules / positive regulation of blood-brain barrier permeability / adherens junction maintenance / positive regulation of cell-cell adhesion mediated by cadherin / RUNX1 regulates expression of components of tight junctions / Tight junction interactions / SARS-CoV-2 targets PDZ proteins in cell-cell junction / establishment of endothelial intestinal barrier / protein localization to cell-cell junction / regulation of cell junction assembly / protein localization to adherens junction / Regulation of gap junction activity / protein localization to bicellular tight junction / bicellular tight junction assembly / gap junction / cell-cell junction organization / Apoptotic cleavage of cell adhesion proteins / tight junction / actomyosin structure organization / podosome / Signaling by Hippo / regulation of bicellular tight junction assembly / cell-cell junction assembly / negative regulation of stress fiber assembly / apical junction complex / maintenance of blood-brain barrier / positive regulation of sprouting angiogenesis / regulation of cytoskeleton organization / bicellular tight junction / cell adhesion molecule binding / cell projection / adherens junction / cell-cell adhesion / cell-cell junction / apical part of cell / cell junction / actin cytoskeleton organization / basolateral plasma membrane / membrane => GO:0016020 / calmodulin binding / cell adhesion / positive regulation of cell migration / cadherin binding / positive regulation of cell population proliferation / negative regulation of apoptotic process / structural molecule activity / protein-containing complex / identical protein binding / plasma membrane / cytoplasm / cytosol Similarity search - Function Claudin-2 / Tight junction protein ZO-1 / ZO-1, SH3 domain / Claudin / Claudin, conserved site / Claudin family signature. / Tight junction protein ZO / Domain present in ZO-1 and Unc5-like netrin receptors / ZU5 domain / ZU5 domain ... Claudin-2 / Tight junction protein ZO-1 / ZO-1, SH3 domain / Claudin / Claudin, conserved site / Claudin family signature. / Tight junction protein ZO / Domain present in ZO-1 and Unc5-like netrin receptors / ZU5 domain / ZU5 domain / ZU5 domain profile. / PMP-22/EMP/MP20/Claudin family / PMP-22/EMP/MP20/Claudin superfamily / Guanylate kinase-like domain profile. / Guanylate kinase-like domain / Variant SH3 domain / Guanylate kinase/L-type calcium channel beta subunit / Guanylate kinase / Guanylate kinase homologues. / PDZ domain / Pdz3 Domain / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Roll / P-loop containing nucleoside triphosphate hydrolase / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.79 Å DetailsAuthors Nomme, J. / Lavie, A. Funding support United States, 2items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK) DK61397 United States National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) AI101676 United States
CitationJournal : J.Biol.Chem. / Year : 2015Title : Structural Basis of a Key Factor Regulating the Affinity between the Zonula Occludens First PDZ Domain and Claudins.Authors : Nomme, J. / Antanasijevic, A. / Caffrey, M. / Van Itallie, C.M. / Anderson, J.M. / Fanning, A.S. / Lavie, A. History Deposition Mar 24, 2015 Deposition site : RCSB / Processing site : RCSBSupersession Apr 1, 2015 ID : 4OEQ Revision 1.0 Apr 1, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Jul 1, 2015 Group : Database referencesRevision 1.2 Jul 15, 2015 Group : Database referencesRevision 1.3 Sep 20, 2017 Group : Author supporting evidence / Database references ... Author supporting evidence / Database references / Derived calculations / Source and taxonomy Category : citation / entity_src_gen ... citation / entity_src_gen / pdbx_audit_support / pdbx_struct_oper_list Item : _citation.journal_id_CSD / _entity_src_gen.pdbx_alt_source_flag ... _citation.journal_id_CSD / _entity_src_gen.pdbx_alt_source_flag / _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operation Revision 1.4 Nov 1, 2017 Group : Author supporting evidence / Category : pdbx_struct_assembly_auth_evidenceRevision 1.5 Dec 11, 2019 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.6 Sep 27, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Show all Show less