Entry | Database: PDB / ID: 4xuz |
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Title | Structure of CTX-M-15 bound to RPX-7009 at 1.5 A |
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Components | Beta-lactamase |
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Keywords | Hydrolase/antibiotic / Hydrolase-antibiotic complex |
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Function / homology | Function and homology information
Beta-lactamase, class-A active site / Beta-lactamase class-A active site. / Beta-lactamase enzyme family / Beta-lactamase, class-A / Beta-lactamase / DD-peptidase/beta-lactamase superfamily / Beta-lactamase/transpeptidase-like / 3-Layer(aba) Sandwich / Alpha BetaSimilarity search - Domain/homology |
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Biological species | Klebsiella pneumoniae subsp. pneumoniae (bacteria) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 1.5 Å |
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Authors | Clifton, M.C. / Gardberg, A. |
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Citation | Journal: J.Med.Chem. / Year: 2015 Title: Discovery of a Cyclic Boronic Acid beta-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases. Authors: Hecker, S.J. / Reddy, K.R. / Totrov, M. / Hirst, G.C. / Lomovskaya, O. / Griffith, D.C. / King, P. / Tsivkovski, R. / Sun, D. / Sabet, M. / Tarazi, Z. / Clifton, M.C. / Atkins, K. / Raymond, ...Authors: Hecker, S.J. / Reddy, K.R. / Totrov, M. / Hirst, G.C. / Lomovskaya, O. / Griffith, D.C. / King, P. / Tsivkovski, R. / Sun, D. / Sabet, M. / Tarazi, Z. / Clifton, M.C. / Atkins, K. / Raymond, A. / Potts, K.T. / Abendroth, J. / Boyer, S.H. / Loutit, J.S. / Morgan, E.E. / Durso, S. / Dudley, M.N. |
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History | Deposition | Jan 26, 2015 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Apr 1, 2015 | Provider: repository / Type: Initial release |
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Revision 1.1 | May 27, 2015 | Group: Database references |
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Revision 1.2 | Sep 27, 2023 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description / Source and taxonomy / Structure summary Category: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / citation / database_2 / entity / entity_src_gen / pdbx_entity_nonpoly / pdbx_initial_refinement_model / pdbx_struct_assembly / pdbx_struct_oper_list Item: _chem_comp.name / _chem_comp.pdbx_synonyms ..._chem_comp.name / _chem_comp.pdbx_synonyms / _citation.journal_id_CSD / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity.pdbx_description / _entity_src_gen.pdbx_alt_source_flag / _pdbx_entity_nonpoly.name / _pdbx_struct_assembly.oligomeric_details / _pdbx_struct_oper_list.symmetry_operation |
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