Entry Database : PDB / ID : 4xnq Structure visualization Downloads & linksTitle Antibody hemagglutinin Complexes ComponentsH5.3 Light chain H5.3 heavy chain Influenza H5 HA head domain VietNam rdt mutations DetailsKeywords Viral protein/Immune system / Antibody / hemagglutinin / neutralization / Viral protein-Immune system complexFunction / homology Function and homology informationFunction Domain/homology Component
viral budding from plasma membrane / clathrin-dependent endocytosis of virus by host cell / host cell surface receptor binding / apical plasma membrane / fusion of virus membrane with host plasma membrane / fusion of virus membrane with host endosome membrane / viral envelope / virion attachment to host cell / host cell plasma membrane / virion membrane / identical protein binding Similarity search - Function Hemagglutinin (Ha1 Chain); Chain: A; domain 1 / Haemagglutinin, alpha/beta domain, HA1 chain / Haemagglutinin, influenzavirus A / Haemagglutinin, HA1 chain, alpha/beta domain superfamily / Haemagglutinin / Haemagglutinin, influenzavirus A/B / Viral capsid/haemagglutinin protein / Immunoglobulins / Alpha-Beta Complex / Immunoglobulin-like ... Hemagglutinin (Ha1 Chain); Chain: A; domain 1 / Haemagglutinin, alpha/beta domain, HA1 chain / Haemagglutinin, influenzavirus A / Haemagglutinin, HA1 chain, alpha/beta domain superfamily / Haemagglutinin / Haemagglutinin, influenzavirus A/B / Viral capsid/haemagglutinin protein / Immunoglobulins / Alpha-Beta Complex / Immunoglobulin-like / Sandwich / Mainly Beta / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human) Influenza A virusMethod X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.001 Å DetailsAuthors Spiller, B.W. / Winarski, K.L. Funding support United States, 2items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) HHSN272200900047C United States National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) 5R21 AI092268 United States
CitationJournal : Proc.Natl.Acad.Sci.USA / Year : 2015Title : Vaccine-elicited antibody that neutralizes H5N1 influenza and variants binds the receptor site and polymorphic sites.Authors : Winarski, K.L. / Thornburg, N.J. / Yu, Y. / Sapparapu, G. / Crowe, J.E. / Spiller, B.W. History Deposition Jan 15, 2015 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jul 15, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Jul 22, 2015 Group : Non-polymer descriptionRevision 1.2 Jul 29, 2015 Group : Database referencesRevision 1.3 Aug 12, 2015 Group : Database referencesRevision 1.4 Sep 9, 2015 Group : Source and taxonomyRevision 1.5 Sep 13, 2017 Group : Author supporting evidence / Derived calculations / Category : pdbx_audit_support / pdbx_struct_oper_listItem : _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operationRevision 1.6 Dec 11, 2019 Group : Author supporting evidence / Data collection / Database referencesCategory : chem_comp / citation ... chem_comp / citation / citation_author / pdbx_audit_support Item : _chem_comp.type / _pdbx_audit_support.funding_organizationRevision 2.0 Jul 29, 2020 Group : Atomic model / Data collection ... Atomic model / Data collection / Derived calculations / Structure summary Category : atom_site / chem_comp ... atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / struct_asym / struct_conn / struct_site / struct_site_gen Item : _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ... _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.type_symbol / _chem_comp.name / _chem_comp.type / _pdbx_struct_assembly_gen.asym_id_list / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id Description : Carbohydrate remediation / Provider : repository / Type : RemediationRevision 2.1 Mar 30, 2022 Group : Author supporting evidence / Database references ... Author supporting evidence / Database references / Derived calculations / Structure summary Category : chem_comp / database_2 ... chem_comp / database_2 / pdbx_audit_support / struct_conn Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ... _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_audit_support.funding_organization / _struct_conn.pdbx_leaving_atom_flag
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