登録情報 データベース : PDB / ID : 4xjs 構造の表示 ダウンロードとリンクタイトル Human CD38 complexed with inhibitor 1 [6-fluoro-2-methyl-4-[(2,3,6-trichlorobenzyl)amino]quinoline-8-carboxamide] 要素ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 詳細 キーワード Hydrolase / Transferase / CD38機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase / phosphorus-oxygen lyase activity / artery smooth muscle contraction / Nicotinate metabolism / ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase / NAD+ nucleosidase activity / NAD metabolic process / NAD+ nucleotidase, cyclic ADP-ribose generating / negative regulation of bone resorption / response to hydroperoxide ... 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase / phosphorus-oxygen lyase activity / artery smooth muscle contraction / Nicotinate metabolism / ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase / NAD+ nucleosidase activity / NAD metabolic process / NAD+ nucleotidase, cyclic ADP-ribose generating / negative regulation of bone resorption / response to hydroperoxide / long-term synaptic depression / 加水分解酵素; 糖加水分解酵素; N-グリコシル化合物加水分解酵素 / B cell proliferation / response to retinoic acid / positive regulation of B cell proliferation / positive regulation of vasoconstriction / response to interleukin-1 / response to progesterone / female pregnancy / apoptotic signaling pathway / B cell receptor signaling pathway / positive regulation of insulin secretion / negative regulation of neuron projection development / response to estradiol / positive regulation of cytosolic calcium ion concentration / transferase activity / positive regulation of cell growth / basolateral plasma membrane / nuclear membrane / response to hypoxia / response to xenobiotic stimulus / negative regulation of DNA-templated transcription / negative regulation of apoptotic process / positive regulation of DNA-templated transcription / cell surface / signal transduction / extracellular exosome / identical protein binding / membrane / plasma membrane 類似検索 - 分子機能 ADP Ribosyl Cyclase; Chain A, domain 1 / ADP Ribosyl Cyclase; Chain A, domain 1 / ADP-ribosyl cyclase (CD38/157) / ADP-ribosyl cyclase / NAD(P)-binding Rossmann-like Domain / Up-down Bundle / Rossmann fold / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 Chem-733 / 5-O-phosphono-alpha-D-ribofuranose / ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / 分子置換 / 解像度 : 2.8 Å 詳細データ登録者 Shewchuk, L.M. / Deaton, D. / Stewart, E. 引用ジャーナル : J.Med.Chem. / 年 : 2015タイトル : Discovery of 4-Amino-8-quinoline Carboxamides as Novel, Submicromolar Inhibitors of NAD-Hydrolyzing Enzyme CD38.著者: Becherer, J.D. / Boros, E.E. / Carpenter, T.Y. / Cowan, D.J. / Deaton, D.N. / Haffner, C.D. / Jeune, M.R. / Kaldor, I.W. / Poole, J.C. / Preugschat, F. / Rheault, T.R. / Schulte, C.A. / ... 著者 : Becherer, J.D. / Boros, E.E. / Carpenter, T.Y. / Cowan, D.J. / Deaton, D.N. / Haffner, C.D. / Jeune, M.R. / Kaldor, I.W. / Poole, J.C. / Preugschat, F. / Rheault, T.R. / Schulte, C.A. / Shearer, B.G. / Shearer, T.W. / Shewchuk, L.M. / Smalley, T.L. / Stewart, E.L. / Stuart, J.D. / Ulrich, J.C. 履歴 登録 2015年1月9日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2015年8月26日 Provider : repository / タイプ : Initial release改定 1.1 2015年9月9日 Group : Database references改定 1.2 2015年9月23日 Group : Database references改定 2.0 2020年7月29日 Group : Atomic model / Data collection ... Atomic model / Data collection / Database references / Derived calculations カテゴリ : atom_site / chem_comp ... atom_site / chem_comp / citation / pdbx_chem_comp_identifier / pdbx_struct_oper_list / struct_conn / struct_site / struct_site_gen Item : _atom_site.auth_atom_id / _atom_site.label_atom_id ... _atom_site.auth_atom_id / _atom_site.label_atom_id / _chem_comp.mon_nstd_flag / _chem_comp.type / _citation.journal_id_CSD / _pdbx_struct_oper_list.symmetry_operation / _struct_conn.ptnr2_label_atom_id 解説 : Carbohydrate remediation / Provider : repository / タイプ : Remediation改定 2.1 2023年9月27日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description / Structure summary カテゴリ : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ... _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag
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