登録情報 データベース : PDB / ID : 4wxi 構造の表示 ダウンロードとリンクタイトル FACTOR XIA IN COMPLEX WITH THE INHIBITOR trans-N-{(1S)-1-[4-(3-amino-2H-indazol-6-yl)pyridin-2-yl]-2-phenylethyl}-4-(aminomethyl)cyclohexanecarboxamide 要素COAGULATION FACTOR XI, LIGHT CHAIN 詳細 キーワード hydrolase/hydrolase inhibitor / HYDROLASE / SERINE PROTEASE / BLOOD COAGULATION FACTOR / PROTEIN INHIBITOR COMPLEX / hydrolase-hydrolase inhibitor complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
coagulation factor XIa / serine-type aminopeptidase activity / Defective F9 activation / positive regulation of fibrinolysis / plasminogen activation / Intrinsic Pathway of Fibrin Clot Formation / blood coagulation / heparin binding / serine-type endopeptidase activity / extracellular space ... coagulation factor XIa / serine-type aminopeptidase activity / Defective F9 activation / positive regulation of fibrinolysis / plasminogen activation / Intrinsic Pathway of Fibrin Clot Formation / blood coagulation / heparin binding / serine-type endopeptidase activity / extracellular space / extracellular exosome / extracellular region / identical protein binding / membrane / plasma membrane 類似検索 - 分子機能 Apple domain. / Apple domain / APPLE domain / PAN/Apple domain profile. / PAN domain / PAN/Apple domain / Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Serine proteases, trypsin family, histidine active site. / Peptidase S1A, chymotrypsin family ... Apple domain. / Apple domain / APPLE domain / PAN/Apple domain profile. / PAN domain / PAN/Apple domain / Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Serine proteases, trypsin family, histidine active site. / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, serine active site. / Serine proteases, trypsin domain profile. / Trypsin-like serine protease / Serine proteases, trypsin domain / Trypsin / Trypsin-like serine proteases / Thrombin, subunit H / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / Beta Barrel / Mainly Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.6 Å 詳細データ登録者 Wei, A. 引用ジャーナル : Bioorg.Med.Chem.Lett. / 年 : 2015タイトル : Pyridine and pyridinone-based factor XIa inhibitors.
著者: Corte, J.R. / Fang, T. / Hangeland, J.J. / Friends, T.J. / Rendina, A.R. / Luettgen, J.M. / Bozarth, J.M. / Barbera, F.A. / Rossi, K.A. / Wei, A. / Ramamurthy, V. / Morin, P.E. / Seiffert, D. ... 著者 : Corte, J.R. / Fang, T. / Hangeland, J.J. / Friends, T.J. / Rendina, A.R. / Luettgen, J.M. / Bozarth, J.M. / Barbera, F.A. / Rossi, K.A. / Wei, A. / Ramamurthy, V. / Morin, P.E. / Seiffert, D.A. / Wexler, R.R. / Quan, M.L. 残り2件を表示 表示を減らす#1: ジャーナル : J.Med.Chem. / 年 : 2014タイトル : Tetrahydroquinoline Derivatives as Potent and Selective Factor XIa Inhibitor
著者: Quan, M.L. / Wong, P.C. / Woerner, F. / Smallheer, J.M. / Barbera, F.A. / Bozrarth, J.M. / Brown, R.L. / Harpel, M.R. / Luettgen, J.M. / Morin, P.E. / Peterson, T. / Ramamurthy, V. / Rendina, ... 著者 : Quan, M.L. / Wong, P.C. / Woerner, F. / Smallheer, J.M. / Barbera, F.A. / Bozrarth, J.M. / Brown, R.L. / Harpel, M.R. / Luettgen, J.M. / Morin, P.E. / Peterson, T. / Ramamurthy, V. / Rendina, A.R. / Rossi, K.A. / Watson, C.A. / Wei, A. / Zhang, G. / Sieffert, D. / Wexler, R.R. #2: ジャーナル : J.Med.Chem. / 年 : 2014タイトル : Phenylimidazoles as Potent and Selective Inhibitors of Coagulation Factor XIa with in Vivo Antithrombotic Activity
著者: Hangeland, J.J. / Friends, T.J. / Rossi, K.A. / Smallheer, J.M. / Wang, C. / Sun, Z. / Corte, J.R. / Fang, T. / Wong, P.C. / Rendina, A.A. / Barbera, F.A. / Bozarth, J.M. / Luettgen, J.M. / ... 著者 : Hangeland, J.J. / Friends, T.J. / Rossi, K.A. / Smallheer, J.M. / Wang, C. / Sun, Z. / Corte, J.R. / Fang, T. / Wong, P.C. / Rendina, A.A. / Barbera, F.A. / Bozarth, J.M. / Luettgen, J.M. / Watson, C.A. / Zhang, G. / Wei, A. / Ramamurthy, V. / Morin, P.E. / Bisacchi, G.S. / Subramaniam, S. / Arunachalam, P. / Mathur, A. / Seiffert, D.A. / Wexler, R.R. / Quan, M.L. 履歴 登録 2014年11月13日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2015年1月28日 Provider : repository / タイプ : Initial release改定 1.1 2015年2月11日 Group : Database references改定 1.2 2015年2月18日 Group : Database references改定 1.3 2018年8月29日 Group : Data collection / Derived calculations ... Data collection / Derived calculations / Source and taxonomy / Structure summary カテゴリ : entity / entity_src_gen ... entity / entity_src_gen / entity_src_nat / pdbx_struct_assembly / pdbx_struct_oper_list Item : _entity.src_method / _pdbx_struct_assembly.oligomeric_details / _pdbx_struct_oper_list.symmetry_operation改定 1.4 2024年11月13日 Group : Data collection / Database references ... Data collection / Database references / Refinement description / Structure summary カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_entry_details / pdbx_initial_refinement_model / pdbx_modification_feature / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details
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