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Title | Phenylimidazoles as Potent and Selective Inhibitors of Coagulation Factor XIa with in Vivo Antithrombotic Activity. |
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Journal, issue, pages | J. Med. Chem., Vol. 57, Page 9915-9932, Year 2014 |
Publish date | Jul 7, 2014 (structure data deposition date) |
![]() | Hangeland, J.J. / Friends, T.J. / Rossi, K.A. / Smallheer, J.M. / Wang, C. / Sun, Z. / Corte, J.R. / Fang, T. / Wong, P.C. / Rendina, A.R. ...Hangeland, J.J. / Friends, T.J. / Rossi, K.A. / Smallheer, J.M. / Wang, C. / Sun, Z. / Corte, J.R. / Fang, T. / Wong, P.C. / Rendina, A.R. / Barbera, F.A. / Bozarth, J.M. / Luettgen, J.M. / Watson, C.A. / Zhang, G. / Wei, A. / Ramamurthy, V. / Morin, P.E. / Bisacchi, G.S. / Subramaniam, S. / Arunachalam, P. / Mathur, A. / Seiffert, D.A. / Wexler, R.R. / Quan, M.L. |
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Methods | X-ray diffraction |
Resolution | 1.85 - 2.09 Å |
Structure data | ![]() PDB-4ty6: ![]() PDB-4ty7: |
Chemicals | ![]() ChemComp-39D: ![]() ChemComp-SO4: ![]() ChemComp-EDO: ![]() ChemComp-HOH: ![]() ChemComp-39F: |
Source |
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![]() | Hydrolase/Hydrolase Inhibitor / HYDROLASE / SERINE PROTEASE / BLOOD COAGULATION FACTOR / PROTEIN INHIBITOR COMPLEX / Hydrolase-Hydrolase Inhibitor complex |